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    RCAR1 regulatory component of ABA receptor 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838452, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RCAR1
    Official Full Name
    regulatory component of ABA receptor 1
    Primary source
    TAIR:AT1G01360
    Locus tag
    AT1G01360
    See related
    Araport:AT1G01360
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F6F3.16; F6F3_16; PYL9; PYRABACTIN RESISTANCE 1-LIKE 9; regulatory component of ABA receptor 1
    Summary
    Encodes RCAR1 (regulatory components of ABA receptor). Interacts with and regulates the type 2C protein phosphatases (PP2Cs) ABI1 and ABI2. Functions as abscisic acid sensor.
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    Genomic context

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    See RCAR1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    3
    Sequence:
    Chromosome: 1; NC_003070.9 (141870..143261)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Zinc finger (CCCH-type/C3HC4-type RING finger) family protein Neighboring gene Putative endonuclease or glycosyl hydrolase Neighboring gene Histone superfamily protein Neighboring gene Homeodomain-like superfamily protein Neighboring gene UDP-Glycosyltransferase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ABA receptor PYL9 promotes drought resistance and leaf senescence. Zhao Y, et al. Proc Natl Acad Sci U S A, 2016 Feb 16. PMID 26831097, Free PMC Article
    2. Mechanism of high-affinity abscisic acid binding to PYL9/RCAR1. Nakagawa M, et al. Genes Cells, 2014 May. PMID 24645846
    3. PHYTOCHROME-INTERACTING FACTORS Interact with the ABA Receptors PYL8 and PYL9 to Orchestrate ABA Signaling in Darkness. Qi L, et al. Mol Plant, 2020 Mar 2. PMID 32059872
    4. AtRAE1 is involved in degradation of ABA receptor RCAR1 and negatively regulates ABA signalling in Arabidopsis. Li D, et al. Plant Cell Environ, 2018 Jan. PMID 29044697
    5. The ABA receptor PYL9 together with PYL8 plays an important role in regulating lateral root growth. Xing L, et al. Sci Rep, 2016 Jun 3. PMID 27256015, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PHYTOCHROME-INTERACTING FACTORS Interact with the ABA Receptors PYL8 and PYL9 to Orchestrate ABA Signaling in Darkness.
      Title: PHYTOCHROME-INTERACTING FACTORS Interact with the ABA Receptors PYL8 and PYL9 to Orchestrate ABA Signaling in Darkness.
    2. AtRAE1 likely participates in ABA signalling through regulating the degradation of abscissic acid receptor RCAR1.
      Title: AtRAE1 is involved in degradation of ABA receptor RCAR1 and negatively regulates ABA signalling in Arabidopsis.
    3. Results show that PYL9 not just binds to MYB transcription factors, but also regulates their transcriptional activity, and that this is a point of convergence between abscisic acid and auxin pathways.
      Title: The ABA receptor PYL9 together with PYL8 plays an important role in regulating lateral root growth.
    4. Data indicate that bscisic acid (ABA) signaling is repressed by group A type 2C protein phosphatases (PP2Cs), and then ABA binds to its receptor of the ACTIN RESISTANCE1 (PYR1), PYR1-LIKE (PYL), and REGULATORY COMPONENTS OF ABA RECEPTORS (RCAR) family, which, in turn, inhibits PP2Cs and activates downstream ABA signaling.
      Title: A Novel Chemical Inhibitor of ABA Signaling Targets All ABA Receptors.
    5. results uncover the molecular mechanism of ABA-induced leaf senescence and suggest an important role of PYL9 and leaf senescence in promoting resistance to extreme drought stress
      Title: ABA receptor PYL9 promotes drought resistance and leaf senescence.
    6. Structural and binding studies of PYL9 reveals that the nonpolar triplet (Ile110, Val162, and Leu165) and Pro64 contribute to enhance ABA-binding affinity by inducing a shift of the ABA carboxyl group to form additional direct bonds with Asn169.
      Title: Mechanism of high-affinity abscisic acid binding to PYL9/RCAR1.
    7. RCAR receptor contributes to ozone, reduced air humidity and darkness induced stomatal regulation.
      Title: PYR/RCAR receptors contribute to ozone-, reduced air humidity-, darkness-, and CO2-induced stomatal regulation.
    8. ROP11 protects ABI1 phosphatase activity from inhibition by RCAR1/PYL9 and thus negatively regulates abscissic acid signaling.
      Title: ROP11 GTPase negatively regulates ABA signaling by protecting ABI1 phosphatase activity from inhibition by the ABA receptor RCAR1/PYL9 in Arabidopsis.
    9. Data reveal that this CPL is an important site necessary for both the phosphatase activity of ABI2 and the functional interaction between ABI2 and PYL5/9 ABA receptors.
      Title: Identification of an important site for function of the type 2C protein phosphatase ABI2 in abscisic acid signalling in Arabidopsis.
    10. X-ray data is reported for PYL9/RCAR1, PYL5/RCAR8 and PYR1/RCAR11 in the presence of (+)-abscisic acid. The three proteins crystallize in space groups P3(1)21/P3(2)21, P2 and P1, respectively. X-ray intensity data were collected to 1.9-2.6 A resolution.
      Title: Crystallization of the plant hormone receptors PYL9/RCAR1, PYL5/RCAR8 and PYR1/RCAR11 in the presence of (+)-abscisic acid.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_100018.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables abscisic acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables abscisic acid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein phosphatase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables signaling receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in abscisic acid-activated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in abscisic acid-activated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    regulatory component of ABA receptor 1
    NP_563626.1
    • regulatory component of ABA receptor 1 (RCAR1); CONTAINS InterPro DOMAIN/s: Polyketide cyclase/dehydrase (InterPro:IPR019587); BEST Arabidopsis thaliana protein match is: PYR1-like 7 (TAIR:AT4G01026.1); Has 395 Blast hits to 395 proteins in 28 species: Archae - 0; Bacteria - 3; Metazoa - 0; Fungi - 0; Plants - 392; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      141870..143261
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100018.5 → NP_563626.1  regulatory component of ABA receptor 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_563626.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q84MC7, Q8LA91, Q9LNI7
      UniProtKB/TrEMBL
      A0A178W4H4, A0A5S9S2L3
      Conserved Domains (1) summary
      cd07821
      Location:34 → 178
      PYR_PYL_RCAR_like; Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q84MC7.1

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