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    mtLPD1 mitochondrial lipoamide dehydrogenase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841221, updated on 18-Sep-2024

    Summary

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    Official Symbol
    mtLPD1
    Official Full Name
    mitochondrial lipoamide dehydrogenase 1
    Primary source
    TAIR:AT1G48030
    Locus tag
    AT1G48030
    See related
    Araport:AT1G48030
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    mitochondrial lipoamide dehydrogenase 1; T2J15.6
    Summary
    Encodes a mitochondrial lipoamide dehydrogenase whose expression is induced by light.
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    Genomic context

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    See mtLPD1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    2
    Sequence:
    Chromosome: 1; NC_003070.9 (17716893..17719500, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Plant invertase/pectin methylesterase inhibitor superfamily protein Neighboring gene pectin methylesterase inhibitor 1 Neighboring gene Protein phosphatase 2C family protein Neighboring gene Ku80 family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of two cDNAs encoding mitochondrial lipoamide dehydrogenase from Arabidopsis. Lutziger I, et al. Plant Physiol, 2001 Oct. PMID 11598235, Free PMC Article
    2. Mitochondrial Dihydrolipoyl Dehydrogenase Activity Shapes Photosynthesis and Photorespiration of Arabidopsis thaliana. Timm S, et al. Plant Cell, 2015 Jul. PMID 26116608, Free PMC Article
    3. Leaf proteome responses of Arabidopsis thaliana exposed to mild cadmium stress. Semane B, et al. J Plant Physiol, 2010 Mar 1. PMID 20005002
    4. Identification and molecular properties of SUMO-binding proteins in Arabidopsis. Park HC, et al. Mol Cells, 2011 Aug. PMID 21607647, Free PMC Article
    5. Internal architecture of mitochondrial complex I from Arabidopsis thaliana. Klodmann J, et al. Plant Cell, 2010 Mar. PMID 20197505, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpression of mtLPD improves photosynthesis and, in turn, biomass accumulation in Arabidopsis. [mtLPD1]
      Title: Mitochondrial Dihydrolipoyl Dehydrogenase Activity Shapes Photosynthesis and Photorespiration of Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001333289.1
    NM_001333290.1
    NM_001333291.1
    NM_103699.5
    NM_179451.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding HDA PubMed 
    enables cobalt ion binding HDA PubMed 
    enables copper ion binding HDA PubMed 
    enables dihydrolipoyl dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding HDA PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to cadmium ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to light stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    NOT located_in Golgi apparatus RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in apoplast HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus HDA PubMed 
    part_of respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitochondrial lipoamide dehydrogenase 1
    NP_175237.1
    • mitochondrial lipoamide dehydrogenase 1 (mtLPD1); FUNCTIONS IN: dihydrolipoyl dehydrogenase activity, copper ion binding, cobalt ion binding, zinc ion binding, ATP binding; INVOLVED IN: response to cadmium ion, response to light stimulus; LOCATED IN: mitochondrion, apoplast, mitochondrial respiratory chain complex I, mitochondrial matrix; EXPRESSED IN: 28 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), Pyridine nucleotide-disulphide oxidoreductase, class I, active site (InterPro:IPR012999), Pyridine nucleotide-disulphide oxidoreductase, dimerisation (InterPro:IPR004099), Dihydrolipoamide dehydrogenase (InterPro:IPR006258), FAD/NAD-linked reductase, dimerisation (InterPro:IPR016156), Mercuric reductase (InterPro:IPR000815), Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region (InterPro:IPR001327); BEST Arabidopsis thaliana protein match is: lipoamide dehydrogenase 2 (TAIR:AT3G17240.3); Has 41363 Blast hits to 41324 proteins in 3251 species: Archae - 1062; Bacteria - 30027; Metazoa - 916; Fungi - 551; Plants - 652; Viruses - 0; Other Eukaryotes - 8155 (source: NCBI BLink).
    NP_849782.1
    • lipoamide dehydrogenase 1 (LPD1); FUNCTIONS IN: dihydrolipoyl dehydrogenase activity, copper ion binding, cobalt ion binding, zinc ion binding, ATP binding; INVOLVED IN: response to cadmium ion, response to light stimulus; LOCATED IN: mitochondrion, apoplast, mitochondrial respiratory chain complex I, mitochondrial matrix; EXPRESSED IN: 28 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), Pyridine nucleotide-disulphide oxidoreductase, class I, active site (InterPro:IPR012999), Pyridine nucleotide-disulphide oxidoreductase, dimerisation (InterPro:IPR004099), Dihydrolipoamide dehydrogenase (InterPro:IPR006258), FAD/NAD-linked reductase, dimerisation (InterPro:IPR016156), Mercuric reductase (InterPro:IPR000815), Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region (InterPro:IPR001327); BEST Arabidopsis thaliana protein match is: lipoamide dehydrogenase 2 (TAIR:AT3G17240.3); Has 41519 Blast hits to 41478 proteins in 3269 species: Archae - 1065; Bacteria - 30177; Metazoa - 918; Fungi - 552; Plants - 652; Viruses - 0; Other Eukaryotes - 8155 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      17716893..17719500 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_103699.5 → NP_175237.1  mitochondrial lipoamide dehydrogenase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_175237.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LNF3, Q9M5K3
      UniProtKB/TrEMBL
      A0A178W162, A0A5S9WML4
      Conserved Domains (1) summary
      cl39093
      Location:41 → 507
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    2. NM_001333289.1 → NP_001322048.1  mitochondrial lipoamide dehydrogenase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LNF3, Q9M5K3
      UniProtKB/TrEMBL
      A0A178W162, A0A5S9WML4
      Conserved Domains (1) summary
      cl39093
      Location:41 → 507
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    3. NM_001333291.1 → NP_001322047.1  mitochondrial lipoamide dehydrogenase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LNF3, Q9M5K3
      UniProtKB/TrEMBL
      A0A178W162, A0A5S9WML4
      Conserved Domains (1) summary
      cl39093
      Location:41 → 507
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    4. NM_001333290.1 → NP_001322049.1  mitochondrial lipoamide dehydrogenase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LNF3, Q9M5K3
      UniProtKB/TrEMBL
      A0A178W162, A0A5S9WML4
      Conserved Domains (1) summary
      cl39093
      Location:41 → 507
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    5. NM_179451.1 → NP_849782.1  mitochondrial lipoamide dehydrogenase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849782.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LNF3, Q9M5K3
      UniProtKB/TrEMBL
      A0A178W162, A0A5S9WML4
      Conserved Domains (1) summary
      cl39093
      Location:41 → 507
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M5K3.2

    Gene LinkOut

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