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    ERH3 P-loop containing nucleoside triphosphate hydrolases superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 844375, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ERH3
    Official Full Name
    P-loop containing nucleoside triphosphate hydrolases superfamily protein
    Primary source
    TAIR:AT1G80350
    Locus tag
    AT1G80350
    See related
    Araport:AT1G80350
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AAA1; ARABIDOPSIS THALIANA KATANIN SMALL SUBUNIT; ATKSS; ATKTN1; BOT1; BOTERO 1; CAD ATPASE; ECTOPIC ROOT HAIR 3; F5I6.10; F5I6_10; FAT ROOT; FRA2; FRAGILE FIBER 2; FRC2; FTR; FURCA2; KATANIN 1; KTN1; LUE1
    Summary
    encodes a p60 katanin protein that is expressed throughout the plant. Required for the specification of cell fates from early in development (in the meristem) through differentiation and for normal postmitotic organization of cortical microtubules into transverse arrays in root epidermis cells. Mutants display cytoskeletal defects.
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    Genomic context

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    See ERH3 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    7
    Sequence:
    Chromosome: 1; NC_003070.9 (30205314..30208268, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene gibberellin 3-oxidase 4 Neighboring gene gibberellin 3-oxidase 2 Neighboring gene Pyridoxal phosphate (PLP)-dependent transferases superfamily protein Neighboring gene Cyclin A2;4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. BOTERO1 is required for normal orientation of cortical microtubules and anisotropic cell expansion in Arabidopsis. Bichet A, et al. Plant J, 2001 Jan. PMID 11169190
    2. Katanin's severing activity favors bundling of cortical microtubules in plants. Stoppin-Mellet V, et al. Plant J, 2006 Jun. PMID 16805733
    3. Mechanical stress acts via katanin to amplify differences in growth rate between adjacent cells in Arabidopsis. Uyttewaal M, et al. Cell, 2012 Apr 13. PMID 22500806
    4. A katanin-like protein regulates normal cell wall biosynthesis and cell elongation. Burk DH, et al. Plant Cell, 2001 Apr. PMID 11283338, Free PMC Article
    5. A mechanism for reorientation of cortical microtubule arrays driven by microtubule severing. Lindeboom JJ, et al. Science, 2013 Dec 6. PMID 24200811

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Brassinosteroid signals cooperate with katanin-mediated microtubule severing to control stamen filament elongation.
      Title: Brassinosteroid signals cooperate with katanin-mediated microtubule severing to control stamen filament elongation.
    2. Cytokinesis in fra2 Arabidopsis thaliana p60-Katanin Mutant: Defects in Cell Plate/Daughter Wall Formation.
      Title: Cytokinesis in fra2 Arabidopsis thaliana p60-Katanin Mutant: Defects in Cell Plate/Daughter Wall Formation.
    3. KATANIN-dependent mechanical properties of the stigmatic cell wall mediate the pollen tube path in Arabidopsis.
      Title: KATANIN-dependent mechanical properties of the stigmatic cell wall mediate the pollen tube path in Arabidopsis.
    4. A Novel Katanin-Tethering Machinery Accelerates Cytokinesis.
      Title: A Novel Katanin-Tethering Machinery Accelerates Cytokinesis.
    5. Data show that FRAGILE FIBER 2 (fra2, Katanin mutant had an increased infection rate.
      Title: Cell Wall Modifications in Giant Cells Induced by the Plant Parasitic Nematode Meloidogyne incognita in Wild-Type (Col-0) and the fra2 Arabidopsis thaliana Katanin Mutant.
    6. Work reveals that cross-linking of microtubules by MAP65-1 confers resistance to severing by inhibiting the binding of KTN1 and identifies the structural features of MAP65-1 that are important for this activity.
      Title: Microtubule bundling by MAP65-1 protects against severing by inhibiting the binding of katanin.
    7. The conserved protein CLASP is a potent stabilizer of new plus ends created by katanin severing in plant cells.
      Title: CLASP stabilization of plus ends created by severing promotes microtubule creation and reorientation.
    8. the proteome-wide effects in two KATANIN 1 mutants, are reported.
      Title: Feedback Microtubule Control and Microtubule-Actin Cross-talk in Arabidopsis Revealed by Integrative Proteomic and Cell Biology Analysis of KATANIN 1 Mutants.
    9. loss of KTN1 prevented random microtubule networks from shifting into well-ordered arrays. We further showed that the filamentous actin cap, which is a typical feature of several plant epidermal cell types including root hairs and leaf trichomes, was not observed in the growth apexes of conical cells during cell development.
      Title: Spatio-temporal orientation of microtubules controls conical cell shape in Arabidopsis thaliana petals.
    10. Severing at cortical microtubule crossover sites was completely abolished in the Arabidopsis katanin mutant. Consistent with this finding, GFP-tagged katanin driven by its native promoter localizes at sites of CMT crossover prior to severing.
      Title: Microtubule severing at crossover sites by katanin generates ordered cortical microtubule arrays in Arabidopsis.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_106684.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule severing ATPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within anisotropic cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cortical microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within_positive_effect leaf pavement cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule severing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multidimensional cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within plant-type cell wall biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within trichome branching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of katanin complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    P-loop containing nucleoside triphosphate hydrolases superfamily protein
    NP_178151.1
    • ECTOPIC ROOT HAIR 3 (ERH3); FUNCTIONS IN: nucleoside-triphosphatase activity, nucleotide binding, ATP binding; INVOLVED IN: trichome branching, cortical microtubule organization, multidimensional cell growth, plant-type cell wall biogenesis, microtubule cytoskeleton organization; LOCATED IN: katanin complex; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA-type, core (InterPro:IPR003959), ATPase, AAA+ type, core (InterPro:IPR003593), ATPase, AAA-type, conserved site (InterPro:IPR003960), Vps4 oligomerisation, C-terminal (InterPro:IPR015415); BEST Arabidopsis thaliana protein match is: P-loop containing nucleoside triphosphate hydrolases superfamily protein (TAIR:AT2G34560.1); Has 31677 Blast hits to 29370 proteins in 3124 species: Archae - 1478; Bacteria - 12054; Metazoa - 4742; Fungi - 3292; Plants - 2928; Viruses - 23; Other Eukaryotes - 7160 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      30205314..30208268 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106684.5 → NP_178151.1  P-loop containing nucleoside triphosphate hydrolases superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_178151.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8S9E4, Q9SEX2
      UniProtKB/TrEMBL
      A0A178WF59, A0A384L792, Q0WR11
      Conserved Domains (3) summary
      pfam09336
      Location:479 → 521
      Vps4_C; Vps4 C terminal oligomerization domain
      pfam17862
      Location:434 → 478
      AAA_lid_3; AAA+ lid domain
      cl38936
      Location:240 → 410
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SEX2.1

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