DPMS2 dolichol phosphate-mannose biosynthesis regulatory protein-like protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: DPMS2
Official Full Name: dolichol phosphate-mannose biosynthesis regulatory protein-like protein
Primary source: TAIR:AT1G74340
Locus tag: AT1G74340
See related: Araport:AT1G74340
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: dolichol phosphate mannose synthase 2; F1M20.2; F1M20_2
Summary: Encodes a subunit of the dolichol phosphate mannase synthase (DPMS) complex that may serve as membrane anchors for the catalytic core, DPMS1, or provide catalytic assistance. It is localized in the ER and mediates isoprenyl-linked glycan biogenesis.
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Genomic context

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See DPMS2 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 4

Sequence:: Chromosome: 1; NC_003070.9 (27948045..27951668, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In plants, Dol-P-Man is synthesized when Dol-P-Man synthase1 (DPMS1), the catalytic core, interacts with two binding proteins, DPMS2 and DPMS3, that may serve as membrane anchors for DPMS1 or provide catalytic assistance.
Title: DOLICHOL PHOSPHATE MANNOSE SYNTHASE1 mediates the biogenesis of isoprenyl-linked glycans and influences development, stress response, and ammonium hypersensitivity in Arabidopsis.

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Pathways from PubChem

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General gene information

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Homology

Orthologs from OrthoDB

NM_001334642.1

Supported by ESTs:

NM_106094.7

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
contributes_to dolichyl-phosphate beta-D-mannosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables enzyme regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in dolichol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
part_of dolichol-phosphate-mannose synthase complex	IPI Inferred from Physical Interaction more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dolichol phosphate-mannose biosynthesis regulatory protein-like protein

NP_177574.1

dolichol phosphate-mannose biosynthesis regulatory protein-related; FUNCTIONS IN: molecular_function unknown; INVOLVED IN: macromolecule biosynthetic process; LOCATED IN: integral to endoplasmic reticulum membrane, endomembrane system; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Dolichol phosphate-mannose biosynthesis regulatory (InterPro:IPR009914); Has 224 Blast hits to 224 proteins in 115 species: Archae - 0; Bacteria - 0; Metazoa - 93; Fungi - 78; Plants - 25; Viruses - 0; Other Eukaryotes - 28 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

27948045..27951668 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_106094.7 → NP_177574.1 dolichol phosphate-mannose biosynthesis regulatory protein-like protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_177574.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9CA79

UniProtKB/TrEMBL

A0A5S9WUA9, A0A654EP68

Conserved Domains (1) summary

pfam07297
Location:4 → 79

DPM2; Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2)
NM_001334642.1 → NP_001320932.1 dolichol phosphate-mannose biosynthesis regulatory protein-like protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9CA79

UniProtKB/TrEMBL

A0A5S9WUA9, A0A654EP68

Conserved Domains (1) summary

pfam07297
Location:4 → 79

DPM2; Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2)