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    PP2AA2 protein phosphatase 2A subunit A2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 822171, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PP2AA2
    Official Full Name
    protein phosphatase 2A subunit A2
    Primary source
    TAIR:AT3G25800
    Locus tag
    AT3G25800
    See related
    Araport:AT3G25800
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    PDF1; PHOSPHATASE 2A REGULATORY SUBUNIT; PR 65; protein phosphatase 2A subunit A2; protein phosphatase 2A subunit A2
    Summary
    one of three genes encoding the protein phosphatase 2A regulatory subunit
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    Genomic context

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    See PP2AA2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    12
    Sequence:
    Chromosome: 3; NC_003074.8 (9422476..9426049, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene myb-like transcription factor family protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene Terpenoid cyclases/Protein prenyltransferases superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterisation of cDNA and genomic clones encoding homologues of the 65 kDa regulatory subunit of protein phosphatase 2A in Arabidopsis thaliana. Slabas AR, et al. Plant Mol Biol, 1994 Nov. PMID 7811971
    2. Protein phosphatase 2A holoenzyme is targeted to peroxisomes by piggybacking and positively affects peroxisomal β-oxidation. Kataya AR, et al. Plant Physiol, 2015 Feb. PMID 25489022, Free PMC Article
    3. ROTUNDA3 function in plant development by phosphatase 2A-mediated regulation of auxin transporter recycling. Karampelias M, et al. Proc Natl Acad Sci U S A, 2016 Mar 8. PMID 26888284, Free PMC Article
    4. PP2A activates brassinosteroid-responsive gene expression and plant growth by dephosphorylating BZR1. Tang W, et al. Nat Cell Biol, 2011 Feb. PMID 21258370, Free PMC Article
    5. The non-JAZ TIFY protein TIFY8 from Arabidopsis thaliana is a transcriptional repressor. Cuéllar Pérez A, et al. PLoS One, 2014. PMID 24416306, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001035692.1
    NM_001338767.1
    NM_113479.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase 2A subunit A2
    NP_001030769.1
    • protein phosphatase 2A subunit A2 (PP2AA2); FUNCTIONS IN: protein phosphatase type 2A regulator activity; INVOLVED IN: response to cadmium ion, regulation of phosphorylation; LOCATED IN: plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: HEAT (InterPro:IPR000357), Armadillo-like helical (InterPro:IPR011989), HEAT, type 2 (InterPro:IPR021133), Armadillo-type fold (InterPro:IPR016024); BEST Arabidopsis thaliana protein match is: protein phosphatase 2A subunit A3 (TAIR:AT1G13320.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_189208.1
    • protein phosphatase 2A subunit A2 (PP2AA2); FUNCTIONS IN: protein phosphatase type 2A regulator activity; INVOLVED IN: response to cadmium ion, regulation of phosphorylation; LOCATED IN: plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: HEAT (InterPro:IPR000357), Armadillo-like helical (InterPro:IPR011989), HEAT, type 2 (InterPro:IPR021133), Armadillo-type fold (InterPro:IPR016024); BEST Arabidopsis thaliana protein match is: protein phosphatase 2A subunit A3 (TAIR:AT1G13320.3); Has 2834 Blast hits to 1736 proteins in 250 species: Archae - 15; Bacteria - 74; Metazoa - 1458; Fungi - 417; Plants - 306; Viruses - 0; Other Eukaryotes - 564 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      9422476..9426049 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_113479.5 → NP_189208.1  protein phosphatase 2A subunit A2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_189208.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q38950, Q9LRZ9
      UniProtKB/TrEMBL
      A0A178VIW5, A0A5S9XFL5
      Conserved Domains (2) summary
      COG1413
      Location:196 → 419
      HEAT; HEAT repeat [General function prediction only]
      sd00044
      Location:243 → 267
      HEAT; HEAT repeat [structural motif]

    2. NM_001338767.1 → NP_001326959.1  protein phosphatase 2A subunit A2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q38950, Q9LRZ9
      UniProtKB/TrEMBL
      A0A178VIW5, A0A5S9XFL5
      Conserved Domains (2) summary
      COG1413
      Location:196 → 419
      HEAT; HEAT repeat [General function prediction only]
      sd00044
      Location:243 → 267
      HEAT; HEAT repeat [structural motif]

    3. NM_001035692.1 → NP_001030769.1  protein phosphatase 2A subunit A2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001030769.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4JA59
      Conserved Domains (5) summary
      COG1413
      Location:43 → 301
      HEAT; HEAT repeat [General function prediction only]
      cd00020
      Location:280 → 378
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam12755
      Location:220 → 300
      Vac14_Fab1_bd; Vacuolar 14 Fab1-binding region
      pfam13646
      Location:356 → 461
      HEAT_2; HEAT repeats
      sd00044
      Location:243 → 267
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q38950.2

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