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    Cand2 Protein of unknown function, transmembrane-40 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819662, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Cand2
    Official Full Name
    Protein of unknown function, transmembrane-40
    Primary source
    TAIR:AT3G05010
    Locus tag
    AT3G05010
    See related
    Araport:AT3G05010
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    candidate G-protein Coupled Receptor 2; T9J14.4; T9J14_4
    Summary
    Encodes a candidate G-protein Coupled Receptor that is involved in the regulation of root growth by bacterial N-acyl-homoserine lactones (AHLs) and plays a role in mediating interactions between plants and microbes.
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    Genomic context

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    See Cand2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    6
    Sequence:
    Chromosome: 3; NC_003074.8 (1389371..1391675)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene intracellular protein transporter Neighboring gene Transport protein particle (TRAPP) component Neighboring gene ncRNA Neighboring gene acyl carrier protein 1 Neighboring gene sodium hydrogen exchanger 2 Neighboring gene ncRNA Neighboring gene exportin-4 protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nitric oxide acts downstream of reactive oxygen species in phytomelatonin receptor 1 (PMTR1)-mediated stomatal closure in Arabidopsis. Wang Z, et al. J Plant Physiol, 2023 Mar. PMID 36706575
    2. The Melatonin Receptor CAND2/PMTR1 Is Involved in the Regulation of Mitochondrial Gene Expression under Photooxidative Stress. Bychkov IA, et al. Dokl Biochem Biophys, 2022 Feb. PMID 35275300
    3. Phytomelatonin receptor PMTR1-mediated signaling regulates stomatal closure in Arabidopsis thaliana. Wei J, et al. J Pineal Res, 2018 Sep. PMID 29702752
    4. Two G-protein-coupled-receptor candidates, Cand2 and Cand7, are involved in Arabidopsis root growth mediated by the bacterial quorum-sensing signals N-acyl-homoserine lactones. Jin G, et al. Biochem Biophys Res Commun, 2012 Jan 20. PMID 22206669
    5. CAND2/PMTR1 Is Required for Melatonin-Conferred Osmotic Stress Tolerance in Arabidopsis. Wang LF, et al. Int J Mol Sci, 2021 Apr 13. PMID 33924609, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nitric oxide acts downstream of reactive oxygen species in phytomelatonin receptor 1 (PMTR1)-mediated stomatal closure in Arabidopsis.
      Title: Nitric oxide acts downstream of reactive oxygen species in phytomelatonin receptor 1 (PMTR1)-mediated stomatal closure in Arabidopsis.
    2. The Melatonin Receptor CAND2/PMTR1 Is Involved in the Regulation of Mitochondrial Gene Expression under Photooxidative Stress.
      Title: The Melatonin Receptor CAND2/PMTR1 Is Involved in the Regulation of Mitochondrial Gene Expression under Photooxidative Stress.
    3. CAND2/PMTR1 Is Required for Melatonin-Conferred Osmotic Stress Tolerance in Arabidopsis.
      Title: CAND2/PMTR1 Is Required for Melatonin-Conferred Osmotic Stress Tolerance in Arabidopsis.
    4. results suggest that the phytomelatonin regulation of stomatal closure is dependent on its receptor CAND2/PMTR1-mediated H2 O2 and Ca(2+) signaling transduction cascade.
      Title: Phytomelatonin receptor PMTR1-mediated signaling regulates stomatal closure in Arabidopsis thaliana.
    5. These results suggest that Cand2 and Cand7 are involved in the regulation of root growth by bacterial N-acyl-homoserine lactones and that GPCRs play a role in mediating interactions between plants and microbes.[Cand2]
      Title: Two G-protein-coupled-receptor candidates, Cand2 and Cand7, are involved in Arabidopsis root growth mediated by the bacterial quorum-sensing signals N-acyl-homoserine lactones.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_111373.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables melatonin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables melatonin receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of stomatal closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to mannitol IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to molecule of bacterial origin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to molecule of bacterial origin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to osmotic stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to pheromone IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to pheromone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Protein of unknown function, transmembrane-40
    NP_566244.1
    • Protein of unknown function, transmembrane-40; CONTAINS InterPro DOMAIN/s: Protein of unknown function, transmembrane-40 (InterPro:IPR018781); BEST Arabidopsis thaliana protein match is: Protein of unknown function, transmembrane-40 (TAIR:AT5G27210.1); Has 134 Blast hits to 134 proteins in 47 species: Archae - 0; Bacteria - 6; Metazoa - 78; Fungi - 0; Plants - 49; Viruses - 0; Other Eukaryotes - 1 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      1389371..1391675
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111373.3 → NP_566244.1  Protein of unknown function, transmembrane-40 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566244.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94AH1, Q9CAW5
      UniProtKB/TrEMBL
      A0A178V840, A0A5S9X9J3, A0A654F470
      Conserved Domains (1) summary
      pfam10160
      Location:33 → 287
      Tmemb_40; Predicted membrane protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94AH1.1

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