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    ERMO2 Sec23/Sec24 protein transport family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819896, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ERMO2
    Official Full Name
    Sec23/Sec24 protein transport family protein
    Primary source
    TAIR:AT3G07100
    Locus tag
    AT3G07100
    See related
    Araport:AT3G07100
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtSEC24A; ENDOPLASMIC RETICULUM MORPHOLOGY 2; SEC24A
    Summary
    Encodes SEC24a/ERMO2. Required for endoplasmic reticulum (ER) morphology.
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    Genomic context

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    See ERMO2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    14
    Sequence:
    Chromosome: 3; NC_003074.8 (2245164..2250796, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene EamA-like transporter family Neighboring gene ncRNA Neighboring gene PPPDE putative thiol peptidase family protein Neighboring gene Ribosomal protein L13 family protein Neighboring gene tRNA-Ser

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evidence for the involvement of the Arabidopsis SEC24A in male transmission. Conger R, et al. J Exp Bot, 2011 Oct. PMID 21705385, Free PMC Article
    2. Using Homology Modeling to Understand the Structural Basis of Specific Interaction of a Plant-Specific AtSar1a-AtSec23a Pair Involved in Protein ER Export. Nim YS, et al. Methods Mol Biol, 2017. PMID 28861817
    3. The Vesicle-Forming 6K2 Protein of Turnip Mosaic Virus Interacts with the COPII Coatomer Sec24a for Viral Systemic Infection. Jiang J, et al. J Virol, 2015 Jul. PMID 25878114, Free PMC Article
    4. A missense mutation in the Arabidopsis COPII coat protein Sec24A induces the formation of clusters of the endoplasmic reticulum and Golgi apparatus. Faso C, et al. Plant Cell, 2009 Nov. PMID 19933202, Free PMC Article
    5. GNOM-LIKE1/ERMO1 and SEC24a/ERMO2 are required for maintenance of endoplasmic reticulum morphology in Arabidopsis thaliana. Nakano RT, et al. Plant Cell, 2009 Nov. PMID 19933201, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sar1 and Sec23 interact in the process of endoplasmic reticulum protein export.
      Title: Using Homology Modeling to Understand the Structural Basis of Specific Interaction of a Plant-Specific AtSar1a-AtSec23a Pair Involved in Protein ER Export.
    2. Intercellular movement of Turnip Mosaic Virus replication vesicles thus requires endoplasmic reticulum export of viral 6K2, which is mediated by the interaction of the N-terminal domain of the viral protein with Arabidopsis Sec24a.
      Title: The Vesicle-Forming 6K2 Protein of Turnip Mosaic Virus Interacts with the COPII Coatomer Sec24a for Viral Systemic Infection.
    3. AtSEC24A mutation is tolerated in the female gametophyte but causes defects in pollen leading to failure of male transmission.
      Title: Evidence for the involvement of the Arabidopsis SEC24A in male transmission.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_111590.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within ER body organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within endoplasmic reticulum organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within male gamete generation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA endoreduplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pollen development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_negative_effect sepal giant cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within transport of virus in host, cell to cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of COPII vesicle coat IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Sec23/Sec24 protein transport family protein
    NP_187366.2
    • ENDOPLASMIC RETICULUM MORPHOLOGY 2 (ERMO2); FUNCTIONS IN: transporter activity, zinc ion binding; INVOLVED IN: transport, ER body organization; LOCATED IN: COPII vesicle coat; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Sec23/Sec24, helical domain (InterPro:IPR006900), Sec23/Sec24 beta-sandwich (InterPro:IPR012990), Sec23/Sec24, trunk domain (InterPro:IPR006896), Zinc finger, Sec23/Sec24-type (InterPro:IPR006895), Gelsolin domain (InterPro:IPR007123); BEST Arabidopsis thaliana protein match is: clone eighty-four (TAIR:AT3G44340.1); Has 86818 Blast hits to 46504 proteins in 1607 species: Archae - 60; Bacteria - 12149; Metazoa - 40940; Fungi - 13838; Plants - 8598; Viruses - 2013; Other Eukaryotes - 9220 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      2245164..2250796 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111590.4 → NP_187366.2  Sec23/Sec24 protein transport family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187366.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q56WS8, Q8L7A7, Q9SFU0
      UniProtKB/TrEMBL
      A0A178V9J3, A0A5S9X9V4, A0A7G2EJX9
      Conserved Domains (2) summary
      PHA03247
      Location:2 → 324
      PHA03247; large tegument protein UL36; Provisional
      COG5028
      Location:167 → 1036
      COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SFU0.2

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