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    FRD3 MATE efflux family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819995, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FRD3
    Official Full Name
    MATE efflux family protein
    Primary source
    TAIR:AT3G08040
    Locus tag
    AT3G08040
    See related
    Araport:AT3G08040
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATFRD3; FERRIC REDUCTASE DEFECTIVE 3; MAN1; MANGANESE ACCUMULATOR 1
    Summary
    Encodes a member of the MATE (multidrug and toxin efflux family), expressed in roots but not shoots. Mutants accumulate excess iron, manganese and zinc, and express root Fe(III) chelatase activity even under iron sufficiency conditions. FRD3 is likely to function in root xylem loading of an iron chelator or other factor necessary for efficient iron uptake out of the xylem or apoplastic space and into leaf cells.
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    Genomic context

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    See FRD3 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    13
    Sequence:
    Chromosome: 3; NC_003074.8 (2566196..2569700, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene RNA binding protein Neighboring gene PHD finger family protein Neighboring gene DNA-directed RNA polymerase subunit beta (Protein of unknown function, DUF642) Neighboring gene delta-latroinsectotoxin-Lt1a protein Neighboring gene myb domain protein 83

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comparative expression profiling reveals a role of the root apoplast in local phosphate response. Hoehenwarter W, et al. BMC Plant Biol, 2016 Apr 28. PMID 27121119, Free PMC Article
    2. Abscisic acid alleviates iron deficiency by promoting root iron reutilization and transport from root to shoot in Arabidopsis. Lei GJ, et al. Plant Cell Environ, 2014 Apr. PMID 24111973
    3. Natural variation at the FRD3 MATE transporter locus reveals cross-talk between Fe homeostasis and Zn tolerance in Arabidopsis thaliana. Pineau C, et al. PLoS Genet, 2012. PMID 23236296, Free PMC Article
    4. The FRD3 citrate effluxer promotes iron nutrition between symplastically disconnected tissues throughout Arabidopsis development. Roschzttardtz H, et al. Plant Cell, 2011 Jul. PMID 21742986, Free PMC Article
    5. The FRD3-mediated efflux of citrate into the root vasculature is necessary for efficient iron translocation. Durrett TP, et al. Plant Physiol, 2007 May. PMID 17351051, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GCN5 plays a critical role in FRD3-mediated iron homeostasis.
      Title: GENERAL CONTROL NONREPRESSED PROTEIN5-Mediated Histone Acetylation of FERRIC REDUCTASE DEFECTIVE3 Contributes to Iron Homeostasis in Arabidopsis.
    2. Our results suggest that FRD3 works as a multimer and is involved in loading Zn into xylem
      Title: Natural variation at the FRD3 MATE transporter locus reveals cross-talk between Fe homeostasis and Zn tolerance in Arabidopsis thaliana.
    3. Data suggest that FRD3 mediated-citrate release in the apoplastic space represents an important process by which efficient iron nutrition is achieved between adjacent tissues lacking symplastic connections.
      Title: The FRD3 citrate effluxer promotes iron nutrition between symplastically disconnected tissues throughout Arabidopsis development.
    4. FRD3 effluxes citrate into the root vasculature, a process important for the translocation of iron to the leaves.
      Title: The FRD3-mediated efflux of citrate into the root vasculature is necessary for efficient iron translocation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001337758.1
    NM_111683.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables citrate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables iron ion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables xenobiotic transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to phosphate starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in metal ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to abscisic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    MATE efflux family protein
    NP_001319499.1
    • FERRIC REDUCTASE DEFECTIVE 3 (FRD3); CONTAINS InterPro DOMAIN/s: Multi antimicrobial extrusion protein MatE (InterPro:IPR002528); BEST Arabidopsis thaliana protein match is: MATE efflux family protein (TAIR:AT1G51340.2); Has 16442 Blast hits to 16241 proteins in 2243 species: Archae - 390; Bacteria - 12800; Metazoa - 108; Fungi - 151; Plants - 401; Viruses - 0; Other Eukaryotes - 2592 (source: NCBI BLink).
    NP_187461.1
    • FERRIC REDUCTASE DEFECTIVE 3 (FRD3); FUNCTIONS IN: antiporter activity, transporter activity; INVOLVED IN: cellular iron ion homeostasis; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 4 anthesis, F mature embryo stage, petal differentiation and expansion stage, D bilateral stage; CONTAINS InterPro DOMAIN/s: Multi antimicrobial extrusion protein MatE (InterPro:IPR002528); BEST Arabidopsis thaliana protein match is: MATE efflux family protein (TAIR:AT1G51340.2); Has 16442 Blast hits to 16241 proteins in 2243 species: Archae - 390; Bacteria - 12800; Metazoa - 108; Fungi - 151; Plants - 401; Viruses - 0; Other Eukaryotes - 2592 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      2566196..2569700 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001337758.1 → NP_001319499.1  MATE efflux family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VB30, A0A2H1ZEH4, I2GA74

    2. NM_111683.2 → NP_187461.1  MATE efflux family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187461.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SFB0
      UniProtKB/TrEMBL
      A0A178VB30, I2GA74
      Conserved Domains (2) summary
      cd13136
      Location:55 → 509
      MATE_DinF_like; DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins
      TIGR00797
      Location:55 → 436
      matE; putative efflux protein, MATE family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SFB0.1

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