PEX12 peroxin-12 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: PEX12
Official Full Name: peroxin-12
Primary source: TAIR:AT3G04460
Locus tag: AT3G04460
See related: Araport:AT3G04460
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ABERRANT PEROXISOME MORPHOLOGY 4; APM4; ATPEX12; peroxin-12; PEROXIN-12; T27C4.11; T27C4_11
Summary: RING finger protein involved in peroxisome biogenesis. Also involved in peroxisomal import of nitric oxide synthase. Has been demonstrated to have E3 ubiquitin ligase activity.
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Genomic context

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See PEX12 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 10

Sequence:: Chromosome: 3; NC_003074.8 (1186440..1189508)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

reducing function of the peroxisome-associated ubiquitin-conjugating enzyme PEX4 restored PEX10 levels and partially ameliorated the other molecular and physiological defects of the pex12-1 mutant.
Title: Genetic Interactions between PEROXIN12 and Other Peroxisome-Associated Ubiquitination Components.
Data show that formation of glyoxysomal reticulum seemed to be impaired in PEX10-DeltaZn but not in PEX2-DeltaZn-T7 or PEX12-DeltaZn-T7 plants.
Title: Different functions of the C3HC4 zinc RING finger peroxins PEX10, PEX2, and PEX12 in peroxisome formation and matrix protein import.
APM2/PEX13 and APM4/PEX12 have roles in both PTS1- and PTS2-dependent protein transport on the peroxisomal membrane. [APM4] [PEX12]
Title: The Arabidopsis pex12 and pex13 mutants are defective in both PTS1- and PTS2-dependent protein transport to peroxisomes.
PEX12 is a peroxisomal protein in Arabidopsis and is essential for peroxisome biogenesis and plant development. [AtPEX12]
Title: The Arabidopsis PEX12 gene is required for peroxisome biogenesis and is essential for development.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001337528.1

Supported by ESTs:

NM_111317.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within embryonic morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fatty acid beta-oxidation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within peroxisome organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein import into peroxisome matrix	IDA Inferred from Direct Assay more info	PubMed
involved_in protein import into peroxisome matrix	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein import into peroxisome matrix	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein monoubiquitination	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in peroxisomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: peroxin-12

NP_187096.2

peroxin-12 (PEX12); FUNCTIONS IN: zinc ion binding; INVOLVED IN: protein import into peroxisome matrix, fatty acid beta-oxidation, peroxisome organization, embryonic morphogenesis; LOCATED IN: peroxisomal membrane, peroxisome; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), Pex, N-terminal (InterPro:IPR006845), Peroxisome assembly, p12 (InterPro:IPR017375); Has 364 Blast hits to 340 proteins in 170 species: Archae - 0; Bacteria - 0; Metazoa - 139; Fungi - 134; Plants - 57; Viruses - 0; Other Eukaryotes - 34 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

1186440..1189508

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_111317.4 → NP_187096.2 peroxin-12 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_187096.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8GYG2, Q9M841

UniProtKB/TrEMBL

A0A178VI10

Conserved Domains (2) summary

cd16451
Location:339 → 380

mRING_PEX12; Modified RING finger found in peroxin-12 (PEX12) and similar proteins

pfam04757
Location:20 → 303

Pex2_Pex12; Pex2 / Pex12 amino terminal region
NM_001337528.1 → NP_001325637.1 peroxin-12 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1I9LLU9, A0A5S9X9P0

Conserved Domains (1) summary

pfam04757
Location:20 → 303

Pex2_Pex12; Pex2 / Pex12 amino terminal region