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    WNK2 with no lysine (K) kinase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821810, updated on 18-Sep-2024

    Summary

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    Official Symbol
    WNK2
    Official Full Name
    with no lysine (K) kinase 2
    Primary source
    TAIR:AT3G22420
    Locus tag
    AT3G22420
    See related
    Araport:AT3G22420
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA WITH NO K 2; ATWNK2; PROTEIN KINASE; with no lysine (K) kinase 2; ZIK3
    Summary
    Encodes a member of the WNK family (9 members in all) of protein kinases, the structural design of which is clearly distinct from those of other known protein kinases, such as receptor-like kinases and mitogen-activated protein kinases. Its transcription is under the control of circadian rhythms.
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    Genomic context

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    See WNK2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Sequence:
    Chromosome: 3; NC_003074.8 (7946408..7949177)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Sec14p-like phosphatidylinositol transfer family protein Neighboring gene uncharacterized protein Neighboring gene F-box/associated interaction domain protein Neighboring gene imidazoleglycerol-phosphate dehydratase Neighboring gene RNA recognition motif XS domain protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The plant WNK gene family and regulation of flowering time in Arabidopsis. Wang Y, et al. Plant Biol (Stuttg), 2008 Sep. PMID 18761494
    2. Compilation and characterization of a novel WNK family of protein kinases in Arabiodpsis thaliana with reference to circadian rhythms. Nakamichi N, et al. Biosci Biotechnol Biochem, 2002 Nov. PMID 12506983
    3. An abscisic acid-responsive protein interaction network for sucrose non-fermenting related kinase1 in abiotic stress response. Carianopol CS, et al. Commun Biol, 2020 Mar 26. PMID 32218501, Free PMC Article
    4. A mesoscale abscisic acid hormone interactome reveals a dynamic signaling landscape in Arabidopsis. Lumba S, et al. Dev Cell, 2014 May 12. PMID 24823379
    5. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001338586.1
    NM_113139.3
    NM_202625.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within photoperiodism, flowering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein phosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    with no lysine (K) kinase 2
    NP_188881.1
    • with no lysine (K) kinase 2 (WNK2); CONTAINS InterPro DOMAIN/s: Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: with no lysine (K) kinase 1 (TAIR:AT3G04910.1); Has 103279 Blast hits to 102406 proteins in 3863 species: Archae - 91; Bacteria - 9763; Metazoa - 38283; Fungi - 9889; Plants - 28050; Viruses - 396; Other Eukaryotes - 16807 (source: NCBI BLink).
    NP_974354.1
    • with no lysine (K) kinase 2 (WNK2); CONTAINS InterPro DOMAIN/s: Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: with no lysine (K) kinase 1 (TAIR:AT3G04910.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      7946408..7949177
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001338583.1 → NP_001325810.1  with no lysine (K) kinase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VFG2, A0A1I9LMD0

    2. NM_001338584.1 → NP_001325807.1  with no lysine (K) kinase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LMC7, A0A654F9N6

    3. NM_001338585.1 → NP_001325808.1  with no lysine (K) kinase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VFG2, A0A1I9LMC8

    4. NM_113139.3 → NP_188881.1  with no lysine (K) kinase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188881.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8S8Y9, Q9LUV8
      UniProtKB/TrEMBL
      A0A5S9XEK2, A0A654F9N6
      Conserved Domains (1) summary
      cd13983
      Location:22 → 281
      STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase

    5. NM_001338586.1 → NP_001325809.1  with no lysine (K) kinase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LMC9, A0A654F9N6

    6. NM_202625.2 → NP_974354.1  with no lysine (K) kinase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974354.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VFG2
      Conserved Domains (2) summary
      smart00220
      Location:28 → 313
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13983
      Location:22 → 313
      STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8S8Y9.1

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