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    MSH1 MUTL protein homolog 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 822021, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MSH1
    Official Full Name
    MUTL protein homolog 1
    Primary source
    TAIR:AT3G24320
    Locus tag
    AT3G24320
    See related
    Araport:AT3G24320
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATMSH1; CHLOROPLAST MUTATOR; CHM; CHM1; MUTL protein homolog 1
    Summary
    Promotes re-arrangements of mitochondrial genome. Mutations affects mitochondrial gene expression, and impairs mitochondrial function. Dual targeting of the protein to mitochondria and chloroplasts caused by alternative translation initiation.
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    Genomic context

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    See MSH1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    22
    Sequence:
    Chromosome: 3; NC_003074.8 (8822924..8829728, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene myb domain protein 305 Neighboring gene Sec20 family protein Neighboring gene O-Glycosyl hydrolases family 17 protein Neighboring gene ncRNA Neighboring gene chromatin remodeling 40

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Plant Organellar MSH1 Is a Displacement Loop-Specific Endonuclease. Peñafiel-Ayala A, et al. Plant Cell Physiol, 2024 May 14. PMID 37756637, Free PMC Article
    2. Sorting of mitochondrial and plastid heteroplasmy in Arabidopsis is extremely rapid and depends on MSH1 activity. Broz AK, et al. Proc Natl Acad Sci U S A, 2022 Aug 23. PMID 35969753, Free PMC Article
    3. MSH1 is required for maintenance of the low mutation rates in plant mitochondrial and plastid genomes. Wu Z, et al. Proc Natl Acad Sci U S A, 2020 Jul 14. PMID 32601224, Free PMC Article
    4. Segregation of an MSH1 RNAi transgene produces heritable non-genetic memory in association with methylome reprogramming. Yang X, et al. Nat Commun, 2020 May 5. PMID 32371941, Free PMC Article
    5. The GIY-YIG endonuclease domain of Arabidopsis MutS homolog 1 specifically binds to branched DNA structures. Fukui K, et al. FEBS Lett, 2018 Dec. PMID 30372520

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Plant Organellar MSH1 Is a Displacement Loop-Specific Endonuclease.
      Title: Plant Organellar MSH1 Is a Displacement Loop-Specific Endonuclease.
    2. Sorting of mitochondrial and plastid heteroplasmy in Arabidopsis is extremely rapid and depends on MSH1 activity.
      Title: Sorting of mitochondrial and plastid heteroplasmy in Arabidopsis is extremely rapid and depends on MSH1 activity.
    3. Organellar protein multi-functionality and phenotypic plasticity in plants.
      Title: Organellar protein multi-functionality and phenotypic plasticity in plants.
    4. MSH1-induced heritable enhanced growth vigor through grafting is associated with the RdDM pathway in plants.
      Title: MSH1-induced heritable enhanced growth vigor through grafting is associated with the RdDM pathway in plants.
    5. MSH1 is required for maintenance of the low mutation rates in plant mitochondrial and plastid genomes.
      Title: MSH1 is required for maintenance of the low mutation rates in plant mitochondrial and plastid genomes.
    6. The MUTL protein homolog 1 (msh1) reprogramming is dependent on functional HISTONE DEACETYLASE 6 and methyltransferase MET1, and transition to memory requires the RNA-directed DNA methylation pathway.
      Title: Segregation of an MSH1 RNAi transgene produces heritable non-genetic memory in association with methylome reprogramming.
    7. Results suggest a mechanism for MutS homolog 1 (MSH1)-dependent suppression of homeologous recombination.
      Title: The GIY-YIG endonuclease domain of Arabidopsis MutS homolog 1 specifically binds to branched DNA structures.
    8. Plastid MSH1 depletion results in variegation, abiotic stress tolerance, variable growth rate, and delayed maturity.
      Title: MSH1 Is a Plant Organellar DNA Binding and Thylakoid Protein under Precise Spatial Regulation to Alter Development.
    9. Arabidopsis MSH1 mutation alters the epigenome and produces heritable changes in plant growth.
      Title: Arabidopsis MSH1 mutation alters the epigenome and produces heritable changes in plant growth.
    10. Loss of MSH1 results in programmed phenotypic changes.
      Title: The chloroplast triggers developmental reprogramming when mutS HOMOLOG1 is suppressed in plants.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_001338677.1
    NM_113339.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mismatched DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mismatch repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mitochondrial DNA metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mitochondrial genome maintenance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within mitochondrial genome maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to heat IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plastid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in thylakoid membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    MUTL protein homolog 1
    NP_189075.2
    • MUTL protein homolog 1 (MSH1); FUNCTIONS IN: damaged DNA binding, mismatched DNA binding, catalytic activity, ATP binding, nuclease activity; INVOLVED IN: mismatch repair, mitochondrial genome maintenance, mitochondrial DNA metabolic process; LOCATED IN: mitochondrion, chloroplast; EXPRESSED IN: 13 plant structures; EXPRESSED DURING: 7 growth stages; CONTAINS InterPro DOMAIN/s: Serine/cysteine peptidase, trypsin-like (InterPro:IPR009003), DNA mismatch repair protein MutS, N-terminal (InterPro:IPR016151), Excinuclease ABC, C subunit, N-terminal (InterPro:IPR000305), DNA mismatch repair protein MutS, C-terminal (InterPro:IPR000432), DNA mismatch repair protein MutS-like, N-terminal (InterPro:IPR007695); BEST Arabidopsis thaliana protein match is: MUTS homolog 6 (TAIR:AT4G02070.2); Has 14048 Blast hits to 12806 proteins in 2713 species: Archae - 218; Bacteria - 10179; Metazoa - 621; Fungi - 751; Plants - 393; Viruses - 3; Other Eukaryotes - 1883 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      8822924..8829728 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_113339.4 → NP_189075.2  MUTL protein homolog 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_189075.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q84LK0, Q9LK12
      UniProtKB/TrEMBL
      A0A5S9XF74, A0A654FHT6
      Conserved Domains (3) summary
      cd10438
      Location:1025 → 1094
      GIY-YIG_MSH; Catalytic GIY-YIG domain of eukaryotic DNA mismatch repair protein MutS homologs
      cd03243
      Location:748 → 934
      ABC_MutS_homologs; ATP-binding cassette domain of MutS homologs
      pfam01624
      Location:128 → 226
      MutS_I; MutS domain I

    2. NM_001338677.1 → NP_001326989.1  MUTL protein homolog 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A097PJF1, A0A1I9LQY1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q84LK0.1

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