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    APS1 ATP sulfurylase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821861, updated on 18-Sep-2024

    Summary

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    Official Symbol
    APS1
    Official Full Name
    ATP sulfurylase 1
    Primary source
    TAIR:AT3G22890
    Locus tag
    AT3G22890
    See related
    Araport:AT3G22890
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATP sulfurylase 1
    Summary
    encodes ATP sulfurylase, the first enzyme in the sulfate assimilation pathway of Arabidopsis. It may also participate in selenium metabolism.
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    Genomic context

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    See APS1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    5
    Sequence:
    Chromosome: 3; NC_003074.8 (8112614..8115024)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RNA polymerase Rpb7-like, N-terminal domain-containing protein Neighboring gene ATPase E1-E2 type family protein / haloacid dehalogenase-like hydrolase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Natural variation in the ATPS1 isoform of ATP sulfurylase contributes to the control of sulfate levels in Arabidopsis. Koprivova A, et al. Plant Physiol, 2013 Nov. PMID 24027241, Free PMC Article
    2. Cloning of a cDNA encoding ATP sulfurylase from Arabidopsis thaliana by functional expression in Saccharomyces cerevisiae. Leustek T, et al. Plant Physiol, 1994 Jul. PMID 8058839, Free PMC Article
    3. Analysis of sulfur and selenium assimilation in Astragalus plants with varying capacities to accumulate selenium. Sors TG, et al. Plant J, 2005 Jun. PMID 15941393
    4. Use of TILLING and robotised enzyme assays to generate an allelic series of Arabidopsis thaliana mutants with altered ADP-glucose pyrophosphorylase activity. Hädrich N, et al. J Plant Physiol, 2011 Aug 15. PMID 21345514
    5. Regulatory properties of ADP glucose pyrophosphorylase are required for adjustment of leaf starch synthesis in different photoperiods. Mugford ST, et al. Plant Physiol, 2014 Dec. PMID 25293961, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data how that variation in sulfate levels in natural accessions is partly due to variation in the expression of ATPS1 (At3g22890).
      Title: Natural variation in the ATPS1 isoform of ATP sulfurylase contributes to the control of sulfate levels in Arabidopsis.
    2. TILLING technique was used to generate an allelic series of aps1 mutants in A. thaliana that revealed new insights into the multi-layered regulation of AGPase.
      Title: Use of TILLING and robotised enzyme assays to generate an allelic series of Arabidopsis thaliana mutants with altered ADP-glucose pyrophosphorylase activity.
    3. SLIM1 has a dual function in the regulation of ATPS, directly affecting transcription of the ATPS1 and ATPS4 genes and indirectly regulating the mRNA levels through miR395 expression.
      Title: Interplay of SLIM1 and miR395 in the regulation of sulfate assimilation in Arabidopsis.
    4. there is reciprocal regulation between SULTR2;1 and APS genes through miR395.
      Title: Reciprocal regulation among miR395, APS and SULTR2;1 in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_113189.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables sulfate adenylyltransferase (ATP) activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in hydrogen sulfide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to cadmium ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within selenium compound metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sulfate assimilation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast stroma HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ATP sulfurylase 1
    NP_188929.1
    • ATP sulfurylase 1 (APS1); FUNCTIONS IN: sulfate adenylyltransferase (ATP) activity; INVOLVED IN: response to cadmium ion, response to salt stress; LOCATED IN: chloroplast, plasma membrane, chloroplast stroma; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Rossmann-like alpha/beta/alpha sandwich fold (InterPro:IPR014729), Pseudouridine synthase/archaeosine transglycosylase-like (InterPro:IPR015947), Sulphate adenylyltransferase (InterPro:IPR002650); BEST Arabidopsis thaliana protein match is: Pseudouridine synthase/archaeosine transglycosylase-like family protein (TAIR:AT4G14680.1); Has 2073 Blast hits to 2070 proteins in 648 species: Archae - 98; Bacteria - 862; Metazoa - 241; Fungi - 201; Plants - 187; Viruses - 0; Other Eukaryotes - 484 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      8112614..8115024
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_113189.5 → NP_188929.1  ATP sulfurylase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188929.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q42278, Q42519, Q56Z36, Q8LDJ6, Q9LIK9, Q9SE02
      UniProtKB/TrEMBL
      A0A178VCV2, A0A5S9XEQ4
      Conserved Domains (1) summary
      TIGR00339
      Location:53 → 444
      sopT; ATP sulphurylase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LIK9.1

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