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    NAD(P)-binding Rossmann-fold superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841926, updated on 18-Sep-2024

    Summary

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    Official Full Name
    NAD(P)-binding Rossmann-fold superfamily protein
    Primary source
    TAIR:AT1G54870
    Locus tag
    AT1G54870
    See related
    Araport:AT1G54870
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F14C21.43; F14C21_43
    Summary
    ChlADR is an aldehyde reductase that catalyzes the reduction of the aldehyde carbonyl groups on saturated and alpha,beta-unsaturated aldehydes with more than 5 carbons in vitro. The N-terminal region of this protein directs GFP to the chloroplast where where ChlADR likely helps to maintain the photosynthetic process by detoxifying reactive carbonyls formed during lipid peroxidation. In addition, this enzyme can also reduce cis-3-hexenal, a major plant volatile compound that contributes to green leaf odor, as well as methylglyoxal in vitro.
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    4
    Sequence:
    Chromosome: 1; NC_003070.9 (20458952..20460647)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene HSP20-like chaperones superfamily protein Neighboring gene Glycoprotein membrane precursor GPI-anchored Neighboring gene Late embryogenesis abundant (LEA) protein-like protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NADPH-dependent reductases involved in the detoxification of reactive carbonyls in plants. Yamauchi Y, et al. J Biol Chem, 2011 Mar 4. PMID 21169366, Free PMC Article
    2. The Arabidopsis metacaspase9 degradome. Tsiatsiani L, et al. Plant Cell, 2013 Aug. PMID 23964026, Free PMC Article
    3. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_104360.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables alcohol dehydrogenase (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    NAD(P)-binding Rossmann-fold superfamily protein
    NP_564670.2
    • NAD(P)-binding Rossmann-fold superfamily protein; FUNCTIONS IN: oxidoreductase activity, binding, catalytic activity; INVOLVED IN: oxidation reduction, metabolic process; LOCATED IN: chloroplast; EXPRESSED IN: 8 plant structures; EXPRESSED DURING: M germinated pollen stage, 4 anthesis, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: Short-chain dehydrogenase/reductase, conserved site (InterPro:IPR020904), NAD(P)-binding domain (InterPro:IPR016040), Glucose/ribitol dehydrogenase (InterPro:IPR002347), Short-chain dehydrogenase/reductase SDR (InterPro:IPR002198); BEST Arabidopsis thaliana protein match is: NAD(P)-binding Rossmann-fold superfamily protein (TAIR:AT3G05260.1); Has 123768 Blast hits to 123548 proteins in 3620 species: Archae - 996; Bacteria - 80755; Metazoa - 5748; Fungi - 6562; Plants - 2744; Viruses - 5; Other Eukaryotes - 26958 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      20458952..20460647
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001333678.1 → NP_001322466.1  NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W6Z1, A0A1P8AU36
      Conserved Domains (1) summary
      cd05355
      Location:61 → 336
      SDR_c1; classical (c) SDR, subgroup 1

    2. NM_104360.3 → NP_564670.2  NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564670.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W6Z1
      Conserved Domains (2) summary
      cd05355
      Location:59 → 334
      SDR_c1; classical (c) SDR, subgroup 1
      PRK06701
      Location:52 → 335
      PRK06701; short chain dehydrogenase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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