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    AAP1 amino acid permease 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842205, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AAP1
    Official Full Name
    amino acid permease 1
    Primary source
    TAIR:AT1G58360
    Locus tag
    AT1G58360
    See related
    Araport:AT1G58360
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    amino acid permease 1; AtAAP1; NAT2; NEUTRAL AMINO ACID TRANSPORTER 2
    Summary
    Encodes AAP1 (amino acid permease 1), a neutral amino acid transporter expressed in seeds. Functions in amino acid uptake into embryos. The transporter also functions in acquisition of glutamate and neutral amino acids by the root.
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    Genomic context

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    See AAP1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    6
    Sequence:
    Chromosome: 1; NC_003070.9 (21676388..21680519)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene MATE efflux family protein Neighboring gene Putative serine esterase family protein Neighboring gene glycosyl hydrolase family 10 protein / carbohydrate-binding domain-containing protein Neighboring gene Ribosomal protein S5 family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AAP1 regulates import of amino acids into developing Arabidopsis embryos. Sanders A, et al. Plant J, 2009 Aug. PMID 19392706
    2. AAP1 transports uncharged amino acids into roots of Arabidopsis. Lee YH, et al. Plant J, 2007 Apr. PMID 17419840
    3. Topology of NAT2, a prototypical example of a new family of amino acid transporters. Chang HC, et al. J Biol Chem, 1997 Nov 28. PMID 9374550
    4. Cloning a plant amino acid transporter by functional complementation of a yeast amino acid transport mutant. Hsu LC, et al. Proc Natl Acad Sci U S A, 1993 Aug 15. PMID 8356039, Free PMC Article
    5. Different and overlapping functions of Arabidopsis LHT6 and AAP1 transporters in root amino acid uptake. Perchlik M, et al. J Exp Bot, 2014 Oct. PMID 25005136, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. studies suggested that AAP1 functions in acquisition of glutamate and neutral amino acids when present at soil concentrations.
      Title: Different and overlapping functions of Arabidopsis LHT6 and AAP1 transporters in root amino acid uptake.
    2. AAP1 is important for amino acid import into the embryo for storage protein accumulation and seed yield.
      Title: AAP1 regulates import of amino acids into developing Arabidopsis embryos.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_104616.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables L-alanine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables L-glutamate transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables L-glutamine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables L-proline transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables L-serine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables amino acid transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables amino acid transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables neutral L-amino acid transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within L-alanine transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within L-glutamate import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within amino acid import IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neutral amino acid transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to nematode HEP PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    amino acid permease 1
    NP_176132.1
    • amino acid permease 1 (AAP1); FUNCTIONS IN: neutral amino acid transmembrane transporter activity, amino acid transmembrane transporter activity; INVOLVED IN: neutral amino acid transport, amino acid import, response to nematode; LOCATED IN: plasma membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Amino acid transporter, transmembrane (InterPro:IPR013057); BEST Arabidopsis thaliana protein match is: amino acid permease 8 (TAIR:AT1G10010.1); Has 2298 Blast hits to 2282 proteins in 214 species: Archae - 0; Bacteria - 0; Metazoa - 416; Fungi - 417; Plants - 1313; Viruses - 0; Other Eukaryotes - 152 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      21676388..21680519
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104616.5 → NP_176132.1  amino acid permease 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176132.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O48546, Q42400
      UniProtKB/TrEMBL
      A0A178WEG7, A0A5S9WN63, A0A654EV34
      Conserved Domains (1) summary
      pfam01490
      Location:37 → 472
      Aa_trans; Transmembrane amino acid transporter protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q42400.1

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