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    ATHM2 Thioredoxin superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825653, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ATHM2
    Official Full Name
    Thioredoxin superfamily protein
    Primary source
    TAIR:AT4G03520
    Locus tag
    AT4G03520
    See related
    Araport:AT4G03520
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F9H3.15; F9H3_15; T5L23.1; thioredoxin m2; TRXm2
    Summary
    Encodes a redox activated co-chaperone, chloroplast localized thioredoxin, similar to prokaryotic types.
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    Genomic context

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    See ATHM2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    3
    Sequence:
    Chromosome: 4; NC_003075.7 (1562203..1564204, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Ankyrin repeat family protein Neighboring gene Ankyrin repeat family protein Neighboring gene uncharacterized protein Neighboring gene RING membrane-anchor 1 Neighboring gene pseudo Neighboring gene Uncharacterized protein family (UPF0497)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis mitochondrial voltage-dependent anion channel 3 (AtVDAC3) protein interacts with thioredoxin m2. Zhang M, et al. FEBS Lett, 2015 May 8. PMID 25862497
    2. M-type thioredoxins are involved in the xanthophyll cycle and proton motive force to alter NPQ under low-light conditions in Arabidopsis. Da Q, et al. Plant Cell Rep, 2018 Feb. PMID 29080907
    3. Evidence for a role of chloroplastic m-type thioredoxins in the biogenesis of photosystem II in Arabidopsis. Wang P, et al. Plant Physiol, 2013 Dec. PMID 24151299, Free PMC Article
    4. Alternative targeting of Arabidopsis plastidic glucose-6-phosphate dehydrogenase G6PD1 involves cysteine-dependent interaction with G6PD4 in the cytosol. Meyer T, et al. Plant J, 2011 Jun. PMID 21309870
    5. Dual-targeting of Arabidopsis 6-phosphogluconolactonase 3 (PGL3) to chloroplasts and peroxisomes involves interaction with Trx m2 in the cytosol. Hölscher C, et al. Mol Plant, 2014 Jan. PMID 24008768

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that the m-type thioredoxins TRX-m1, TRX-m2, and TRX-m4 (TRX-ms) interact with the xanthophyll cycle enzyme zeaxanthin epoxidase (ZE) and are required for maintaining the redox-dependent stabilization of ZE.
      Title: M-type thioredoxins are involved in the xanthophyll cycle and proton motive force to alter NPQ under low-light conditions in Arabidopsis.
    2. Results indicate that both AtVDAC3 and AtTrx m2 are involved in ROS signaling and play opposite roles in NaCl stress response.
      Title: Arabidopsis mitochondrial voltage-dependent anion channel 3 (AtVDAC3) protein interacts with thioredoxin m2.
    3. These results suggest an important role for TRX m1, TRX m2, and TRX m4 proteins in the biogenesis of photosystem II.
      Title: Evidence for a role of chloroplastic m-type thioredoxins in the biogenesis of photosystem II in Arabidopsis.
    4. targeting of Arabidopsis 6-phosphogluconolactonase 3 (PGL3) to chloroplasts and peroxisomes
      Title: Dual-targeting of Arabidopsis 6-phosphogluconolactonase 3 (PGL3) to chloroplasts and peroxisomes involves interaction with Trx m2 in the cytosol.
    5. Yeast two-hybrid analyses revealed selective protein-protein interactions of G6PD1 (glucose-6-phosphate dehydrogenase 1) with catalytically inactive G6PD4, and of both G6PD isoforms with plastid-destined thioredoxin M2.
      Title: Alternative targeting of Arabidopsis plastidic glucose-6-phosphate dehydrogenase G6PD1 involves cysteine-dependent interaction with G6PD4 in the cytosol.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001160731.2
    NM_116590.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables enzyme activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-disulfide reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to oxidative stress IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast stroma HDA PubMed 
    located_in chloroplast thylakoid membrane HDA PubMed 
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in thylakoid HDA PubMed 

    General protein information

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    Preferred Names
    Thioredoxin superfamily protein
    NP_001154203.1
    • ATHM2; CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Thioredoxin, core (InterPro:IPR015467), Thioredoxin-like fold (InterPro:IPR012336), Thioredoxin domain (InterPro:IPR013766); BEST Arabidopsis thaliana protein match is: thioredoxin M-type 1 (TAIR:AT1G03680.1); Has 9201 Blast hits to 9185 proteins in 2237 species: Archae - 146; Bacteria - 6732; Metazoa - 24; Fungi - 110; Plants - 264; Viruses - 0; Other Eukaryotes - 1925 (source: NCBI BLink).
    NP_192261.1
    • ATHM2; FUNCTIONS IN: enzyme activator activity; INVOLVED IN: response to oxidative stress, positive regulation of catalytic activity; LOCATED IN: thylakoid, chloroplast thylakoid membrane, chloroplast stroma, chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Thioredoxin, core (InterPro:IPR015467), Thioredoxin domain (InterPro:IPR013766), Thioredoxin, conserved site (InterPro:IPR017937), Thioredoxin (InterPro:IPR005746), Thioredoxin-like subdomain (InterPro:IPR006662), Thioredoxin-like (InterPro:IPR017936), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: thioredoxin M-type 1 (TAIR:AT1G03680.1); Has 20603 Blast hits to 19509 proteins in 2977 species: Archae - 276; Bacteria - 10688; Metazoa - 2669; Fungi - 1127; Plants - 1883; Viruses - 7; Other Eukaryotes - 3953 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      1562203..1564204 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_116590.4 → NP_192261.1  Thioredoxin superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_192261.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q56YG4, Q8LG26, Q9SEU8, Q9ZT79
      UniProtKB/TrEMBL
      A0A178V0B8, A0A5S9XPK2, A0A654FLK3, A0A7G2EZV8
      Conserved Domains (1) summary
      TIGR01068
      Location:85 → 185
      thioredoxin

    2. NM_001160731.2 → NP_001154203.1  Thioredoxin superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001154203.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4JG94
      Conserved Domains (1) summary
      cl00388
      Location:1 → 71
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SEU8.2

    Gene LinkOut

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