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    CLE44 CLAVATA3/ESR-RELATED 44 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 826934, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CLE44
    Official Full Name
    CLAVATA3/ESR-RELATED 44
    Primary source
    TAIR:AT4G13195
    Locus tag
    AT4G13195
    See related
    Araport:AT4G13195
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CLAVATA3/ESR-RELATED 44
    Summary
    Belongs to a large gene family, called CLE for CLAVATA3/ESR-related, encoding small peptides with conserved carboxyl termini. The C-terminal 12 amino acid sequence of CLE44 is identical to that of a dodeca peptide (TDIF, tracheary element differentiation inhibitory factor) isolated from Arabidopsis and functions as a suppressor of plant stem cell differentiation. TDIF sequence is also identical to the C-terminal 12 amino acids of CLE41 (At3g24770). The protein is expressed in the vascular system and is involved in axillary bud formation.
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    Genomic context

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    See CLE44 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    1
    Sequence:
    Chromosome: 4; NC_003075.7 (7661792..7663261, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene zein-binding protein (Protein of unknown function, DUF593) Neighboring gene Ribosomal protein L13 family protein Neighboring gene NAD(P)-binding Rossmann-fold superfamily protein Neighboring gene Protein kinase superfamily protein Neighboring gene uncharacterized protein Neighboring gene Pectin lyase-like superfamily protein Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dodeca-CLE peptides as suppressors of plant stem cell differentiation. Ito Y, et al. Science, 2006 Aug 11. PMID 16902140
    2. Non-cell-autonomous control of vascular stem cell fate by a CLE peptide/receptor system. Hirakawa Y, et al. Proc Natl Acad Sci U S A, 2008 Sep 30. PMID 18812507, Free PMC Article
    3. A novel function of TDIF-related peptides: promotion of axillary bud formation. Yaginuma H, et al. Plant Cell Physiol, 2011 Aug. PMID 21693505
    4. Perception of root-active CLE peptides requires CORYNE function in the phloem vasculature. Hazak O, et al. EMBO Rep, 2017 Aug. PMID 28607033, Free PMC Article
    5. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_117389.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables receptor serine/threonine kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within axillary shoot meristem initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell-cell signaling involved in cell fate commitment ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in maintenance of root meristem identity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phloem development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within phloem or xylem histogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in procambium histogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in xylem development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apoplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    CLAVATA3/ESR-RELATED 44
    NP_567397.1
    • CLAVATA3/ESR-RELATED 44 (CLE44); BEST Arabidopsis thaliana protein match is: CLAVATA3/ESR-RELATED 41 (TAIR:AT3G24770.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      7661792..7663261 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_117389.3 → NP_567397.1  CLAVATA3/ESR-RELATED 44 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567397.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LFN1, Q941C5
      UniProtKB/TrEMBL
      A0A654FNQ0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q941C5.1

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