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    GAE1 UDP-D-glucuronate 4-epimerase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829167, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GAE1
    Official Full Name
    UDP-D-glucuronate 4-epimerase 1
    Primary source
    TAIR:AT4G30440
    Locus tag
    AT4G30440
    See related
    Araport:AT4G30440
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F17I23.220; F17I23_220; UDP-D-glucuronate 4-epimerase 1
    Summary
    UDP-D-glucuronate 4-epimerase
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    Genomic context

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    See GAE1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    1
    Sequence:
    Chromosome: 4; NC_003075.7 (14881689..14883583, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene nodulin MtN21 /EamA-like transporter family protein Neighboring gene tetraspanin9 Neighboring gene ncRNA Neighboring gene glycine-rich protein Neighboring gene glycine-rich protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pectin Biosynthesis Is Critical for Cell Wall Integrity and Immunity in Arabidopsis thaliana. Bethke G, et al. Plant Cell, 2016 Feb. PMID 26813622, Free PMC Article
    2. The biosynthesis of D-Galacturonate in plants. functional cloning and characterization of a membrane-anchored UDP-D-Glucuronate 4-epimerase from Arabidopsis. Mølhøj M, et al. Plant Physiol, 2004 Jul. PMID 15247385, Free PMC Article
    3. Label-free protein quantification for plant Golgi protein localization and abundance. Nikolovski N, et al. Plant Physiol, 2014 Oct. PMID 25122472, Free PMC Article
    4. Separating Golgi Proteins from Cis to Trans Reveals Underlying Properties of Cisternal Localization. Parsons HT, et al. Plant Cell, 2019 Sep. PMID 31266899, Free PMC Article
    5. Integrative Analysis from the Epigenome to Translatome Uncovers Patterns of Dominant Nuclear Regulation during Transient Stress. Lee TA, et al. Plant Cell, 2019 Nov. PMID 31519798, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    NM_119190.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables UDP-glucuronate 4-epimerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to hypoxia HEP PubMed 
    acts_upstream_of_or_within defense response to Gram-negative bacterium IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to fungus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within galacturonate biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi trans cisterna HDA PubMed 
    located_in endosome HDA PubMed 
    located_in trans-Golgi network HDA PubMed 

    General protein information

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    Preferred Names
    UDP-D-glucuronate 4-epimerase 1
    NP_194773.1
    • UDP-D-glucuronate 4-epimerase 1 (GAE1); FUNCTIONS IN: UDP-glucuronate 4-epimerase activity, catalytic activity; INVOLVED IN: cellular metabolic process, carbohydrate metabolic process, nucleotide-sugar metabolic process, metabolic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: NAD-dependent epimerase/dehydratase (InterPro:IPR001509), NAD(P)-binding domain (InterPro:IPR016040), Nucleotide sugar epimerase (InterPro:IPR008089); BEST Arabidopsis thaliana protein match is: UDP-D-glucuronate 4-epimerase 2 (TAIR:AT1G02000.1); Has 43669 Blast hits to 43658 proteins in 3000 species: Archae - 796; Bacteria - 26151; Metazoa - 773; Fungi - 435; Plants - 1177; Viruses - 35; Other Eukaryotes - 14302 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      14881689..14883583 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119190.4 → NP_194773.1  UDP-D-glucuronate 4-epimerase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194773.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9M0B6
      UniProtKB/TrEMBL
      A0A178UXF7, A0A384LBP5, I1VCA9
      Conserved Domains (1) summary
      cl21454
      Location:88 → 418
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M0B6.1

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