SHR GRAS family transcription factor [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: SHR
Official Full Name: GRAS family transcription factor
Primary source: TAIR:AT4G37650
Locus tag: AT4G37650
See related: Araport:AT4G37650
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F19F18.140; F19F18_140; SGR7; SHOOT GRAVITROPISM 7; SHORT ROOT
Summary: Involved in radial organization of the root and shoot axial organs. Essential for normal shoot gravitropism. The protein moves in a highly specific manner from the cells of the stele in which it is synthesized outward. Movement requires sequences within the GRAS and VHIID domains.
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Genomic context

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See SHR in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 1

Sequence:: Chromosome: 4; NC_003075.7 (17691687..17693859)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SHR and SCR coordinate root patterning and growth early in the cell cycle.
Title: SHR and SCR coordinate root patterning and growth early in the cell cycle.
The Arabidopsis SHORTROOT network coordinates shoot apical meristem development with auxin-dependent lateral organ initiation.
Title: The Arabidopsis SHORTROOT network coordinates shoot apical meristem development with auxin-dependent lateral organ initiation.
SHORT-ROOT and SCARECROW homologs regulate patterning of diverse cell types within and between species.
Title: SHORT-ROOT and SCARECROW homologs regulate patterning of diverse cell types within and between species.
A mechanism coordinating root elongation, endodermal differentiation, redox homeostasis and stress response.
Title: A mechanism coordinating root elongation, endodermal differentiation, redox homeostasis and stress response.
SHORTROOT-Mediated Intercellular Signals Coordinate Phloem Development in Arabidopsis Roots.
Title: SHORTROOT-Mediated Intercellular Signals Coordinate Phloem Development in Arabidopsis Roots.
This study showed that INDETERMINATE DOMAIN PROTEIN (ID) binding sequences have a crucial role in the regulation of SCARECROW and SHORT-ROOT expression.[SHR]
Title: INDETERMINATE DOMAIN PROTEIN binding sequences in the 5'-untranslated region and promoter of the SCARECROW gene play crucial and distinct roles in regulating SCARECROW expression in roots and leaves.
interaction of KinG with SHR allows for the formation of stable movement complexes that facilitate the cell-to-cell transport of SHR.
Title: KinG Is a Plant-Specific Kinesin That Regulates Both Intra- and Intercellular Movement of SHORT-ROOT.
In the crystal structures of the SHR-SCR binary and JACKDAW (JKD)/IDD10-SHR-SCR ternary complexes, each GRAS domain comprises one alpha/beta core subdomain with an alpha-helical cap that mediates heterodimerization by forming an intermolecular helix bundle.
Title: Structure of the SHR-SCR heterodimer bound to the BIRD/IDD transcriptional factor JKD.
results provide new insights into the regulatory role of the SHR-SCR-SCL23 network in the endodermis development in both roots and shoots.
Title: Conservation and Diversification of the SHR-SCR-SCL23 Regulatory Network in the Development of the Functional Endodermis in Arabidopsis Shoots.
SHORT-ROOT Deficiency Alleviates the Cell Death Phenotype of the Arabidopsis catalase2 Mutant under Photorespiration-Promoting Conditions
Title: SHORT-ROOT Deficiency Alleviates the Cell Death Phenotype of the Arabidopsis catalase2 Mutant under Photorespiration-Promoting Conditions.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_119928.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within amyloplast organization	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within asymmetric cell division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within leaf development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative gravitropism	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within negative regulation of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in positive gravitropism	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within radial pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of hormone metabolic process	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: GRAS family transcription factor

NP_195480.1

SHORT ROOT (SHR); CONTAINS InterPro DOMAIN/s: Transcription factor GRAS (InterPro:IPR005202); BEST Arabidopsis thaliana protein match is: GRAS family transcription factor (TAIR:AT3G49950.1); Has 2470 Blast hits to 2429 proteins in 304 species: Archae - 0; Bacteria - 4; Metazoa - 9; Fungi - 15; Plants - 2427; Viruses - 0; Other Eukaryotes - 15 (source: NCBI BLink).