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    TRB3 telomere repeat binding factor 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824147, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TRB3
    Official Full Name
    telomere repeat binding factor 3
    Primary source
    TAIR:AT3G49850
    Locus tag
    AT3G49850
    See related
    Araport:AT3G49850
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATTRB3; TBP2; telomere repeat binding factor 3; TELOMERE-BINDING PROTEIN 2
    Summary
    Encodes a telomeric DNA binding protein. In vitro, the protein preferentially binds double-stranded telomeric repeats, but it can also bind to the single G-rich telomeric strand.
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    Genomic context

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    See TRB3 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    6
    Sequence:
    Chromosome: 3; NC_003074.8 (18488993..18490997)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene transmembrane protein (DUF2215) Neighboring gene cysteine-rich TM module stress tolerance protein Neighboring gene ADP-ribosylation factor-like A1B Neighboring gene ADP-ribosylation factor-like A1C

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TRB3 overexpression due to endoplasmic reticulum stress inhibits AKT kinase activation of tongue squamous cell carcinoma. Zhang J, et al. Oral Oncol, 2011 Oct. PMID 21821462
    2. Complementary Activities of TELOMERE REPEAT BINDING Proteins and Polycomb Group Complexes in Transcriptional Regulation of Target Genes. Zhou Y, et al. Plant Cell, 2016 Jan. PMID 26721861, Free PMC Article
    3. AtTRB1, a telomeric DNA-binding protein from Arabidopsis, is concentrated in the nucleolus and shows highly dynamic association with chromatin. Dvorácková M, et al. Plant J, 2010 Feb. PMID 19947985
    4. Characterization of two Arabidopsis thaliana myb-like proteins showing affinity to telomeric DNA sequence. Schrumpfová P, et al. Genome, 2004 Apr. PMID 15060584
    5. Mapping of interaction domains of putative telomere-binding proteins AtTRB1 and AtPOT1b from Arabidopsis thaliana. Schrumpfová PP, et al. FEBS Lett, 2008 Apr 30. PMID 18387366

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Under endoplasmic reticulum stress, TRB3 was up-regulated, resulting in inhibiting the activation of AKT in oral tongue squamous cell carcinoma.
      Title: TRB3 overexpression due to endoplasmic reticulum stress inhibits AKT kinase activation of tongue squamous cell carcinoma.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001339442.1
    NM_114845.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables double-stranded telomeric DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded telomeric DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    telomere repeat binding factor 3
    NP_190554.1
    • telomere repeat binding factor 3 (TRB3); FUNCTIONS IN: single-stranded telomeric DNA binding, DNA binding, protein homodimerization activity, sequence-specific DNA binding transcription factor activity, double-stranded telomeric DNA binding; INVOLVED IN: in 7 processes; LOCATED IN: nucleus, nucleosome; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), SANT, DNA-binding (InterPro:IPR001005), Homeodomain-like (InterPro:IPR009057), Myb, DNA-binding (InterPro:IPR014778), Histone H1/H5 (InterPro:IPR005818), Myb transcription factor (InterPro:IPR015495), Homeodomain-related (InterPro:IPR012287), HTH transcriptional regulator, Myb-type, DNA-binding (InterPro:IPR017930); BEST Arabidopsis thaliana protein match is: Homeodomain-like/winged-helix DNA-binding family protein (TAIR:AT5G67580.2); Has 536 Blast hits to 530 proteins in 102 species: Archae - 0; Bacteria - 0; Metazoa - 28; Fungi - 59; Plants - 395; Viruses - 0; Other Eukaryotes - 54 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      18488993..18490997
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_114845.5 → NP_190554.1  telomere repeat binding factor 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190554.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9M2X3
      UniProtKB/TrEMBL
      A0A178VB21, A0A5S9XJE2, A0A7G2ERJ7
      Conserved Domains (2) summary
      smart00526
      Location:117 → 181
      H15; Domain in histone families 1 and 5
      cd11660
      Location:7 → 56
      SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family

    2. NM_001339442.1 → NP_001326904.1  telomere repeat binding factor 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9M2X3
      UniProtKB/TrEMBL
      A0A178VB21, A0A5S9XJE2, A0A7G2ERJ7
      Conserved Domains (2) summary
      smart00526
      Location:117 → 181
      H15; Domain in histone families 1 and 5
      cd11660
      Location:7 → 56
      SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M2X3.1

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