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    AP3 K-box region and MADS-box transcription factor family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824601, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AP3
    Official Full Name
    K-box region and MADS-box transcription factor family protein
    Primary source
    TAIR:AT3G54340
    Locus tag
    AT3G54340
    See related
    Araport:AT3G54340
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    APETALA 3; ATAP3; FLORAL HOMEOTIC PROTEIN APETALA 3
    Summary
    Floral homeotic gene encoding a MADS domain protein homologous to SRF transcription factors. Specifies petal and stamen identities. Associates with PISTILLATA.
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    Genomic context

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    See AP3 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Sequence:
    Chromosome: 3; NC_003074.8 (20119140..20121314, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene DNA-directed RNA polymerase subunit alpha Neighboring gene Integrase-type DNA-binding superfamily protein Neighboring gene Forkhead-associated (FHA) domain-containing protein Neighboring gene zinc ion binding protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Exogenous Promoter Triggers APETALA3 Silencing through RNA-Directed DNA Methylation Pathway in Arabidopsis. Wang B, et al. Int J Mol Sci, 2019 Sep 11. PMID 31514282, Free PMC Article
    2. Ectopic expression of FaesAP3, a Fagopyrum esculentum (Polygonaceae) AP3 orthologous gene rescues stamen development in an Arabidopsis ap3 mutant. Fang ZW, et al. Gene, 2014 Oct 25. PMID 25149019
    3. Conifer reproductive development involves B-type MADS-box genes with distinct and different activities in male organ primordia. Sundström J, et al. Plant J, 2002 Jul. PMID 12121446
    4. The C-terminal sequence of LMADS1 is essential for the formation of homodimers for B function proteins. Tzeng TY, et al. J Biol Chem, 2004 Mar 12. PMID 14676188
    5. My favourite flowering image: an Arabidopsis inflorescence expressing fluorescent reporters for the APETALA3 and SUPERMAN genes. Prunet N. J Exp Bot, 2019 Nov 18. PMID 29659996, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. My favourite flowering image: an Arabidopsis inflorescence expressing fluorescent reporters for the APETALA3 and SUPERMAN genes.
      Title: My favourite flowering image: an Arabidopsis inflorescence expressing fluorescent reporters for the APETALA3 and SUPERMAN genes.
    2. The expression of AP3 was reactivated and the methylation level of AP3 promoter was also reduced in RNA-Directed DNA Methylation-defective AP3-silencing lines.
      Title: Exogenous Promoter Triggers APETALA3 Silencing through RNA-Directed DNA Methylation Pathway in Arabidopsis.
    3. Ectopic Fagopyrum esculentum AP3 can rescue stamen development in Arabidopsis ap3 mutant.
      Title: Ectopic expression of FaesAP3, a Fagopyrum esculentum (Polygonaceae) AP3 orthologous gene rescues stamen development in an Arabidopsis ap3 mutant.
    4. Data indicate that C function regulator AGAMOUS and the B function regulators APETALA3 and PISTILLATA control many developmental processes in conjunction, as well as independent activities.
      Title: Control of reproductive floral organ identity specification in Arabidopsis by the C function regulator AGAMOUS.
    5. These results imply considerable changes in the composition and topology of the gene network controlled by AP3/PI during the course of flower development.
      Title: Molecular basis for the specification of floral organs by APETALA3 and PISTILLATA.
    6. BNQ genes Are negatively regulated by AP3 and PI in petals.
      Title: The Arabidopsis floral homeotic proteins APETALA3 and PISTILLATA negatively regulate the BANQUO genes implicated in light signaling.
    7. truncated form, lacking the conserved C-terminal motifs, functions to direct floral organ identity specification
      Title: Conserved C-terminal motifs of the Arabidopsis proteins APETALA3 and PISTILLATA are dispensable for floral organ identity function.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_115294.6

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within specification of floral organ identity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in specification of floral organ identity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    K-box region and MADS-box transcription factor family protein
    NP_191002.1
    • APETALA 3 (AP3); CONTAINS InterPro DOMAIN/s: Transcription factor, MADS-box (InterPro:IPR002100), Transcription factor, K-box (InterPro:IPR002487); BEST Arabidopsis thaliana protein match is: AGAMOUS-like 71 (TAIR:AT5G51870.1); Has 6838 Blast hits to 6837 proteins in 855 species: Archae - 0; Bacteria - 0; Metazoa - 626; Fungi - 302; Plants - 5820; Viruses - 0; Other Eukaryotes - 90 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      20119140..20121314 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115294.6 → NP_191002.1  K-box region and MADS-box transcription factor family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191002.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P35632, Q39003, Q8LB79, Q9S7Q3, Q9SQ14, Q9SQ15, Q9SQ16, Q9SQ17, Q9SQ18, Q9SQ19, Q9SQ20, Q9SQ21, Q9SQ22, Q9SX13
      UniProtKB/TrEMBL
      A0A178VHZ2, A0A5S9XL06, A0A7G2ESU4
      Conserved Domains (2) summary
      cd00265
      Location:2 → 80
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam01486
      Location:81 → 169
      K-box; K-box region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35632.1

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