ATPase E1-E2 type family protein / haloacid dehalogenase-like hydrolase family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Full Name: ATPase E1-E2 type family protein / haloacid dehalogenase-like hydrolase family protein
Primary source: TAIR:AT3G63380
Locus tag: AT3G63380
See related: Araport:AT3G63380
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ACA12; auto-inhibited Ca2+ ATPase 12
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Genomic context

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See in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 1

Sequence:: Chromosome: 3; NC_003074.8 (23406484..23410360, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest that the calcium pump activity of plasma membrane Ca(2)-ATPase 12 (ACA12) is primarily regulated by increasing or decreasing mRNA expression and/or protein translation and degradation.
Title: ACA12 is a deregulated isoform of plasma membrane Ca²⁺-ATPase of Arabidopsis thaliana.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

At-8.5BJ-570 (e-PCR)
- UniSTS:229405

At-8BJ-007 (e-PCR)
- UniSTS:229412

Homology

Orthologs from OrthoDB

NM_116203.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables P-type calcium transporter activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within calcium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: ATPase E1-E2 type family protein / haloacid dehalogenase-like hydrolase family protein

NP_191897.1

ATPase E1-E2 type family protein / haloacid dehalogenase-like hydrolase family protein; FUNCTIONS IN: calcium-transporting ATPase activity, calmodulin binding; INVOLVED IN: calcium ion transport, cation transport, metabolic process, ATP biosynthetic process; LOCATED IN: membrane; EXPRESSED IN: 11 plant structures; EXPRESSED DURING: LP.06 six leaves visible, LP.04 four leaves visible, 4 anthesis, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: ATPase, P-type, ATPase-associated domain (InterPro:IPR008250), ATPase, P-type, calcium-transporting, PMCA-type (InterPro:IPR006408), ATPase, P-type, H+ transporting proton pump (InterPro:IPR000695), ATPase, P-type cation-transporter, N-terminal (InterPro:IPR004014), Haloacid dehalogenase-like hydrolase (InterPro:IPR005834), ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter (InterPro:IPR001757), ATPase, P-type phosphorylation site (InterPro:IPR018303), ATPase, P-type cation-transporter, C-terminal (InterPro:IPR006068); BEST Arabidopsis thaliana protein match is: ATPase E1-E2 type family protein / haloacid dehalogenase-like hydrolase family protein (TAIR:AT3G22910.1); Has 46574 Blast hits to 34715 proteins in 3214 species: Archae - 909; Bacteria - 32032; Metazoa - 4086; Fungi - 2666; Plants - 2162; Viruses - 3; Other Eukaryotes - 4716 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

23406484..23410360 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_116203.3 → NP_191897.1 ATPase E1-E2 type family protein / haloacid dehalogenase-like hydrolase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_191897.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8GZ18, Q9LY77

UniProtKB/TrEMBL

A0A178VEV7, A0A5S9XNB7

Conserved Domains (2) summary

cd02081
Location:133 → 882

P-type_ATPase_Ca_PMCA-like; animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1

pfam00689
Location:833 → 1004

Cation_ATPase_C; Cation transporting ATPase, C-terminus