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    NAKR1 Heavy metal transport/detoxification superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831874, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NAKR1
    Official Full Name
    Heavy metal transport/detoxification superfamily protein
    Primary source
    TAIR:AT5G02600
    Locus tag
    AT5G02600
    See related
    Araport:AT5G02600
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    NPCC6; nuclear-enriched phloem companion cell gene 6; SODIUM POTASSIUM ROOT DEFECTIVE 1; T22P11.190; T22P11_190
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    Genomic context

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    See NAKR1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    4
    Sequence:
    Chromosome: 5; NC_003076.8 (584162..586953, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene argininosuccinate lyase Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene ncRNA Neighboring gene Ribosomal L29 family protein Neighboring gene tRNA-Arg

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis NPCC6/NaKR1 is a phloem mobile metal binding protein necessary for phloem function and root meristem maintenance. Tian H, et al. Plant Cell, 2010 Dec. PMID 21193571, Free PMC Article
    2. NaKR1 regulates long-distance movement of FLOWERING LOCUS T in Arabidopsis. Zhu Y, et al. Nat Plants, 2016 May 27. PMID 27255839
    3. SODIUM POTASSIUM ROOT DEFECTIVE1 regulates FLOWERING LOCUS T expression via the microRNA156-SQUAMOSA PROMOTER BINDING PROTEIN-LIKE3 module in response to potassium conditions. Negishi K, et al. Plant Cell Physiol, 2018 Feb 1. PMID 29253219
    4. Mapping the signaling network of BIN2 kinase using TurboID-mediated biotin labeling and phosphoproteomics. Kim TW, et al. Plant Cell, 2023 Mar 15. PMID 36660928, Free PMC Article
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001342660.1
    NM_120338.4
    NM_202994.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables metal ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phloem transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sodium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Heavy metal transport/detoxification superfamily protein
    NP_568105.1
    • Heavy metal transport/detoxification superfamily protein; FUNCTIONS IN: metal ion binding; INVOLVED IN: metal ion transport; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Heavy metal transport/detoxification protein (InterPro:IPR006121); BEST Arabidopsis thaliana protein match is: Chloroplast-targeted copper chaperone protein (TAIR:AT2G37390.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_974723.1
    • Heavy metal transport/detoxification superfamily protein; FUNCTIONS IN: metal ion binding; INVOLVED IN: metal ion transport; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Heavy metal transport/detoxification protein (InterPro:IPR006121); BEST Arabidopsis thaliana protein match is: Chloroplast-targeted copper chaperone protein (TAIR:AT2G37390.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      584162..586953 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_202994.3 → NP_974723.1  Heavy metal transport/detoxification superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974723.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LDS4, Q9LZ42
      UniProtKB/TrEMBL
      A0A178UA80
      Conserved Domains (1) summary
      cd00371
      Location:253 → 306
      HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...

    2. NM_001342660.1 → NP_001332073.1  Heavy metal transport/detoxification superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UA80, A0A1P8BFU9

    3. NM_120338.4 → NP_568105.1  Heavy metal transport/detoxification superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568105.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LDS4, Q9LZ42
      UniProtKB/TrEMBL
      A0A178UA80
      Conserved Domains (1) summary
      cd00371
      Location:253 → 306
      HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LDS4.1

    Gene LinkOut

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