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    TFL1 PEBP (phosphatidylethanolamine-binding protein) family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831683, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TFL1
    Official Full Name
    PEBP (phosphatidylethanolamine-binding protein) family protein
    Primary source
    TAIR:AT5G03840
    Locus tag
    AT5G03840
    See related
    Araport:AT5G03840
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MED24.6; TERMINAL FLOWER 1; TFL-1
    Summary
    Controls inflorescence meristem identity. Involved in the floral initiation process. Ortholog of the Antirrhinum gene CENTRORADIALIS (CEN). Involved in protein trafficking to the protein storage vacuole.
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    Genomic context

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    See TFL1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    4
    Sequence:
    Chromosome: 5; NC_003076.8 (1024500..1025872, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene GDSL-like Lipase/Acylhydrolase family protein Neighboring gene CDK inhibitor P21 binding protein Neighboring gene Nucleic acid-binding, OB-fold-like protein Neighboring gene ncRNA Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TERMINAL FLOWER1 Functions as a Mobile Transcriptional Cofactor in the Shoot Apical Meristem. Goretti D, et al. Plant Physiol, 2020 Apr. PMID 31996406, Free PMC Article
    2. Effects of sugar on vegetative development and floral transition in Arabidopsis. Ohto M, et al. Plant Physiol, 2001 Sep. PMID 11553753, Free PMC Article
    3. A Mutation in the Arabidopsis TFL1 Gene Affects Inflorescence Meristem Development. Shannon S, et al. Plant Cell, 1991 Sep. PMID 12324621, Free PMC Article
    4. Hormone-regulated inflorescence induction and TFL1 expression in Arabidopsis callus in vitro. Guan CM, et al. Plant Cell Rep, 2006 Nov. PMID 16676184
    5. TERMINAL FLOWER1 is a mobile signal controlling Arabidopsis architecture. Conti L, et al. Plant Cell, 2007 Mar. PMID 17369370, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TERMINAL FLOWER1 Functions as a Mobile Transcriptional Cofactor in the Shoot Apical Meristem.
      Title: TERMINAL FLOWER1 Functions as a Mobile Transcriptional Cofactor in the Shoot Apical Meristem.
    2. TERMINAL FLOWER 1-FD complex target genes and competition with FLOWERING LOCUS T.
      Title: TERMINAL FLOWER 1-FD complex target genes and competition with FLOWERING LOCUS T.
    3. Results sugest that flowering locus t protein (FT)/TWIN SISTER OF FT protein (TSF) and TERMINAL FLOWER 1 protein (TFL1) play antagonistic roles in the determination of inflorescence meristem identity, and that FT/TSF are more important than TFL1 in this process.
      Title: Genetic interactions reveal the antagonistic roles of FT/TSF and TFL1 in the determination of inflorescence meristem identity in Arabidopsis.
    4. These observations are consistent with the long-standing but not demonstrated model where CO can inhibit FT induction of flowering by affecting TFL1 expression.
      Title: CONSTANS delays Arabidopsis flowering under short days.
    5. TFL1 can act outside of its normal expression domain in leaf primordia or floral meristems to repress flower identity. These data show how the timing and spatial pattern of TFL1 expression affect overall plant architecture.
      Title: Changing the spatial pattern of TFL1 expression reveals its key role in the shoot meristem in controlling Arabidopsis flowering architecture.
    6. the expression of Dt2 is unable to repress TFL1 in Arabidopsis, further demonstrating the evolutionary novelty of the regulatory mechanism underlying stem growth in soybean.
      Title: Innovation of a Regulatory Mechanism Modulating Semi-determinate Stem Growth through Artificial Selection in Soybean.
    7. conserved and diverse functions of the FT/TFL1 gene
      Title: The FLOWERING LOCUS T/TERMINAL FLOWER 1 Gene Family: Functional Evolution and Molecular Mechanisms.
    8. The results identify AGO1 as a repressor of TFL1 expression. AGO1 plays a role in inflorescence development, controlling the production of coflorescences. AGO1 seems to play this role through regulating TFL1 expression.
      Title: AGO1 controls arabidopsis inflorescence architecture possibly by regulating TFL1 expression.
    9. The balance of the FT and TFL1 gene expression is important for determining flowering behavior.
      Title: Interlocking feedback loops govern the dynamic behavior of the floral transition in Arabidopsis.
    10. Data indicate that BRANCHED1 (BRC1) interacts with the florigen proteins FLOWERING LOCUS T (FT) and TWIN SISTER OF FT (TSF) but not with TERMINAL FLOWER1, a floral repressor.
      Title: BRANCHED1 interacts with FLOWERING LOCUS T to repress the floral transition of the axillary meristems in Arabidopsis.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_120465.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables transcription coregulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within meristem determinacy IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein targeting to vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to sucrose IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    PEBP (phosphatidylethanolamine-binding protein) family protein
    NP_196004.1
    • TERMINAL FLOWER 1 (TFL1); CONTAINS InterPro DOMAIN/s: Phosphatidylethanolamine-binding, conserved site (InterPro:IPR001858), Phosphatidylethanolamine-binding protein PEBP (InterPro:IPR008914); BEST Arabidopsis thaliana protein match is: centroradialis (TAIR:AT2G27550.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      1024500..1025872 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_120465.3 → NP_196004.1  PEBP (phosphatidylethanolamine-binding protein) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196004.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04756, O04757, O04758, P93003
      UniProtKB/TrEMBL
      A0A178UKP0, A0A384L909, A0A7G2F4U8, Q547P7, Q8LSG8, Q8LSH0
      Conserved Domains (1) summary
      cl00227
      Location:4 → 177
      PEBP; PhosphatidylEthanolamine-Binding Protein (PEBP) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P93003.1

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