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    FAD-linked oxidases family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830546, updated on 18-Sep-2024

    Summary

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    Official Full Name
    FAD-linked oxidases family protein
    Primary source
    TAIR:AT5G06580
    Locus tag
    AT5G06580
    See related
    Araport:AT5G06580
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F15M7.11; F15M7_11
    Summary
    Encodes a protein with glycolate dehydrogenase activity, which was shown to complement various subunits of the E. coli glycolate oxidase complex. It has not been ruled out that the enzyme might be involved in other catalytic activities in vivo.
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    18
    Sequence:
    Chromosome: 5; NC_003076.8 (2011245..2016583, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene myosin-binding protein (Protein of unknown function, DUF593) Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene uncharacterized protein Neighboring gene ubiquitin-specific protease 12 Neighboring gene lipase (DUF620)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. D-Lactate dehydrogenase as a marker gene allows positive selection of transgenic plants. Wienstroer J, et al. FEBS Lett, 2012 Jan 2. PMID 22155004
    2. Mitochondrial glycolate oxidation contributes to photorespiration in higher plants. Niessen M, et al. J Exp Bot, 2007. PMID 17595195
    3. A glycolate dehydrogenase in the mitochondria of Arabidopsis thaliana. Bari R, et al. J Exp Bot, 2004 Mar. PMID 14966218
    4. d-Lactate Dehydrogenase Links Methylglyoxal Degradation and Electron Transport through Cytochrome c. Welchen E, et al. Plant Physiol, 2016 Oct. PMID 27506242, Free PMC Article
    5. Two D-2-hydroxy-acid dehydrogenases in Arabidopsis thaliana with catalytic capacities to participate in the last reactions of the methylglyoxal and beta-oxidation pathways. Engqvist M, et al. J Biol Chem, 2009 Sep 11. PMID 19586914, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpression of d-Lactate dehydrogenase (d-LDH) and cytochrome c (CYTc) increased tolerance to d-lactate and methylglyoxal (MGO.
      Title: d-Lactate Dehydrogenase Links Methylglyoxal Degradation and Electron Transport through Cytochrome c.
    2. AtGDH contributes to glycolate metabolism in Arabidopsis, indicating conservation of the chlorophyte pathway in higher plants. [AtGDH] [GDH]
      Title: Mitochondrial glycolate oxidation contributes to photorespiration in higher plants.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_120741.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding HDA PubMed 
    enables D-lactate dehydrogenase (cytochrome) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables D-lactate dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycolate dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within methylglyoxal catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in methylglyoxal catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    FAD-linked oxidases family protein
    NP_568170.1
    • FAD-linked oxidases family protein; FUNCTIONS IN: glycolate oxidase activity, glycolate dehydrogenase activity, D-lactate dehydrogenase (cytochrome) activity, ATP binding; LOCATED IN: mitochondrion; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: FAD-linked oxidase, FAD-binding, subdomain 2 (InterPro:IPR016168), FAD-binding, type 2 (InterPro:IPR016166), FAD-linked oxidase, C-terminal (InterPro:IPR004113), FAD-linked oxidase-like, C-terminal (InterPro:IPR016164), FAD linked oxidase, N-terminal (InterPro:IPR006094), FAD-binding, type 2, subdomain 1 (InterPro:IPR016167); BEST Arabidopsis thaliana protein match is: FAD-linked oxidases family protein (TAIR:AT4G36400.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      2011245..2016583 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_120741.3 → NP_568170.1  FAD-linked oxidases family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568170.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94AX4, Q9FG12
      UniProtKB/TrEMBL
      A0A178UIT0, A0A5S9Y1Y8, A0A654FYU6
      Conserved Domains (1) summary
      PLN02805
      Location:9 → 567
      PLN02805; D-lactate dehydrogenase [cytochrome]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94AX4.1

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