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    PPH pheophytinase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831225, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PPH
    Official Full Name
    pheophytinase
    Primary source
    TAIR:AT5G13800
    Locus tag
    AT5G13800
    See related
    Araport:AT5G13800
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Co-regulated with NYE1; CRN1; MAC12.25; MAC12_25; pheophytinase
    Summary
    Encodes a pheophytinase that is involved in chlorophyll breakdown. Its transcript levels increase during senescence and pph-1 mutants have a stay-green phenotype.
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    Genomic context

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    See PPH in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    7
    Sequence:
    Chromosome: 5; NC_003076.8 (4451733..4454813, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Pentatricopeptide repeat (PPR-like) superfamily protein Neighboring gene Acyl-CoA N-acyltransferases (NAT) superfamily protein Neighboring gene AGAMOUS-like 15 Neighboring gene Glutaredoxin family protein Neighboring gene telomeric DNA binding protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A naturally occurring epiallele associates with leaf senescence and local climate adaptation in Arabidopsis accessions. He L, et al. Nat Commun, 2018 Jan 31. PMID 29386641, Free PMC Article
    2. Catalytic and structural properties of pheophytinase, the phytol esterase involved in chlorophyll breakdown. Guyer L, et al. J Exp Bot, 2018 Feb 12. PMID 29036670, Free PMC Article
    3. Reverse genetic identification of CRN1 and its distinctive role in chlorophyll degradation in Arabidopsis. Ren G, et al. J Integr Plant Biol, 2010 May. PMID 20537045
    4. Pheophytin pheophorbide hydrolase (pheophytinase) is involved in chlorophyll breakdown during leaf senescence in Arabidopsis. Schelbert S, et al. Plant Cell, 2009 Mar. PMID 19304936, Free PMC Article
    5. Suppressor of Overexpression of CO 1 Negatively Regulates Dark-Induced Leaf Degreening and Senescence by Directly Repressing Pheophytinase and Other Senescence-Associated Genes in Arabidopsis. Chen J, et al. Plant Physiol, 2017 Mar. PMID 28096189, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pheophytinase has high specificity for the acid moiety of the ester bond, namely the porphyrin ring, while the nature of the alcohol, namely the phytol chain in pheophytin, is irrelevant.
      Title: Catalytic and structural properties of pheophytinase, the phytol esterase involved in chlorophyll breakdown.
    2. NMR19-4 as an epiallele that controls leaf senescence by regulating the expression of PHEOPHYTIN PHEOPHORBIDE HYDROLASE (PPH). [NMR19]
      Title: A naturally occurring epiallele associates with leaf senescence and local climate adaptation in Arabidopsis accessions.
    3. PPH role in leaf senescence and climate adaptation
      Title: A naturally occurring epiallele associates with leaf senescence and local climate adaptation in Arabidopsis accessions.
    4. Results indicate that SUPPRESSOR OF OVEREXPRESSION OF CO 1 (SOC1) inhibits chlorophyll degradation via negatively regulating pheophytinase (PPH) expression.
      Title: Suppressor of Overexpression of CO 1 Negatively Regulates Dark-Induced Leaf Degreening and Senescence by Directly Repressing Pheophytinase and Other Senescence-Associated Genes in Arabidopsis.
    5. CRN1 (Co-regulated with NYE1) plays a crucial role in Chlorophyll degradation.[CRN1]
      Title: Reverse genetic identification of CRN1 and its distinctive role in chlorophyll degradation in Arabidopsis.
    6. Data identify pheophytinase (PPH), a chloroplast-located and senescence-induced hydrolase widely distributed in algae and land plants, and suggest that it is an important component of the chlorophyll breakdown machinery of senescent leaves. [PPH]
      Title: Pheophytin pheophorbide hydrolase (pheophytinase) is involved in chlorophyll breakdown during leaf senescence in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    NM_001343294.1
    NM_001343295.1
    NM_121383.4
    NM_180484.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables pheophytinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pheophytinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chlorophyll catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chlorophyll catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    pheophytinase
    NP_196884.1
    • pheophytinase (PPH); FUNCTIONS IN: hydrolase activity, pheophytinase activity; INVOLVED IN: chlorophyll catabolic process; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Alpha/beta hydrolase fold-1 (InterPro:IPR000073); BEST Arabidopsis thaliana protein match is: alpha/beta-Hydrolases superfamily protein (TAIR:AT4G36530.2); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).
    NP_850815.1
    • pheophytinase (PPH); FUNCTIONS IN: hydrolase activity, pheophytinase activity; INVOLVED IN: chlorophyll catabolic process; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Alpha/beta hydrolase fold-1 (InterPro:IPR000073); BEST Arabidopsis thaliana protein match is: alpha/beta-Hydrolases superfamily protein (TAIR:AT4G36530.2); Has 3014 Blast hits to 3012 proteins in 698 species: Archae - 17; Bacteria - 1970; Metazoa - 110; Fungi - 4; Plants - 264; Viruses - 0; Other Eukaryotes - 649 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      4451733..4454813 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180484.3 → NP_850815.1  pheophytinase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850815.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FFZ1
      UniProtKB/TrEMBL
      A0A178U971
      Conserved Domains (1) summary
      PLN02578
      Location:93 → 411
      PLN02578; hydrolase

    2. NM_121383.4 → NP_196884.1  pheophytinase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196884.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FFZ1
      UniProtKB/TrEMBL
      A0A178U971
      Conserved Domains (1) summary
      PLN02578
      Location:93 → 411
      PLN02578; hydrolase

    3. NM_001343294.1 → NP_001330304.1  pheophytinase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178U971, A0A1P8BAE0

    4. NM_001343295.1 → NP_001330305.1  pheophytinase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178U971, A0A1P8BAD5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FFZ1.1

    Gene LinkOut

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