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    ORC3 origin recognition complex subunit 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831530, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ORC3
    Official Full Name
    origin recognition complex subunit 3
    Primary source
    TAIR:AT5G16690
    Locus tag
    AT5G16690
    See related
    Araport:AT5G16690
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATORC3; F5E19.30; F5E19_30; origin recognition complex subunit 3; ORIGIN RECOGNITION COMPLEX SUBUNIT 3
    Summary
    Origin Recognition Complex subunit 3. Involved in the initiation of DNA replication. Regulated transcriptionally during cell cycle, peaking at G1/S-phase. Target of E2F/DF family of transcription factors. Interacts with all ORC subunits except ORC1b.
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    Genomic context

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    See ORC3 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    16
    Sequence:
    Chromosome: 5; NC_003076.8 (5474366..5480067)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Chaperone DnaJ-domain superfamily protein Neighboring gene Low-density receptor-like protein Neighboring gene RING/FYVE/PHD zinc finger superfamily protein Neighboring gene Glycosyl hydrolase superfamily protein Neighboring gene dehydroascorbate reductase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conserved initiator proteins in eukaryotes. Gavin KA, et al. Science, 1995 Dec 8. PMID 7502077
    2. The genes encoding Arabidopsis ORC subunits are E2F targets and the two ORC1 genes are differently expressed in proliferating and endoreplicating cells. Diaz-Trivino S, et al. Nucleic Acids Res, 2005. PMID 16179646, Free PMC Article
    3. ABAP1 is a novel plant Armadillo BTB protein involved in DNA replication and transcription. Masuda HP, et al. EMBO J, 2008 Oct 22. PMID 18818695, Free PMC Article
    4. Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thaliana. Van Leene J, et al. Mol Syst Biol, 2010 Aug 10. PMID 20706207, Free PMC Article
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_121674.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of nuclear origin of replication recognition complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    part_of origin recognition complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    origin recognition complex subunit 3
    NP_197171.2
    • origin recognition complex subunit 3 (ORC3); CONTAINS InterPro DOMAIN/s: Origin recognition complex, subunit 3, N-terminal (InterPro:IPR010748), Origin recognition complex, subunit 3 (InterPro:IPR020795); Has 319 Blast hits to 284 proteins in 117 species: Archae - 0; Bacteria - 0; Metazoa - 161; Fungi - 89; Plants - 45; Viruses - 0; Other Eukaryotes - 24 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      5474366..5480067
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001343461.1 → NP_001330900.1  origin recognition complex subunit 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BC82

    2. NM_121674.4 → NP_197171.2  origin recognition complex subunit 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197171.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6E7H0, Q9LFE8
      UniProtKB/TrEMBL
      A0A178UNG9, A0A5S9Y5E3
      Conserved Domains (1) summary
      cd20704
      Location:84 → 732
      Orc3; Origin recognition complex subunit 3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6E7H0.1

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