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    SDH2-2 succinate dehydrogenase 2-2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834065, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SDH2-2
    Official Full Name
    succinate dehydrogenase 2-2
    Primary source
    TAIR:AT5G40650
    Locus tag
    AT5G40650
    See related
    Araport:AT5G40650
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MNF13.170; MNF13_170; succinate dehydrogenase 2-2
    Summary
    One of three isoforms of the iron-sulfur component of the succinate dehydrogenase complex, a component of the mitochondrial respiratory chain complex II. The product of the nuclear encoded gene is imported into the mitochondrion. Expressed during germination and post-germinative growth.
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    Genomic context

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    See SDH2-2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    2
    Sequence:
    Chromosome: 5; NC_003076.8 (16281394..16283527)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Ubiquitin-like superfamily protein Neighboring gene uncharacterized protein Neighboring gene RPM1-interacting protein 4 (RIN4) family protein Neighboring gene ATP12 protein-like protein Neighboring gene PQ-loop repeat family protein / transmembrane family protein Neighboring gene Galactose oxidase/kelch repeat superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nuclear SDH2-1 and SDH2-2 genes, encoding the iron-sulfur subunit of mitochondrial complex II in Arabidopsis, have distinct cell-specific expression patterns and promoter activities. Elorza A, et al. Plant Physiol, 2004 Dec. PMID 15563621, Free PMC Article
    2. A nuclear gene for the iron-sulfur subunit of mitochondrial complex II is specifically expressed during Arabidopsis seed development and germination. Elorza A, et al. Plant Cell Physiol, 2006 Jan. PMID 16249327
    3. Three different genes encode the iron-sulfur subunit of succinate dehydrogenase in Arabidopsis thaliana. Figueroa P, et al. Plant Mol Biol, 2001 May. PMID 11442063
    4. Mitochondrial cytochrome c oxidase and succinate dehydrogenase complexes contain plant specific subunits. Millar AH, et al. Plant Mol Biol, 2004 Sep. PMID 15604729
    5. Functional and composition differences between mitochondrial complex II in Arabidopsis and rice are correlated with the complex genetic history of the enzyme. Huang S, et al. Plant Mol Biol, 2010 Feb. PMID 19924544

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An analysis of the expression of SDH2-1, SDH2-2, and SDH2-3 (not detected) in A. thaliana, including differential expression in plant organs.
      Title: Nuclear SDH2-1 and SDH2-2 genes, encoding the iron-sulfur subunit of mitochondrial complex II in Arabidopsis, have distinct cell-specific expression patterns and promoter activities.
    2. during germination the embryo-specific SDH2-3 is replaced by SDH2-1 or SDH2-2 in mitochondrial complex II
      Title: A nuclear gene for the iron-sulfur subunit of mitochondrial complex II is specifically expressed during Arabidopsis seed development and germination.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001344348.1
    NM_123430.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables electron transfer activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables electron transfer activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables succinate dehydrogenase (quinone) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables succinate dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables zinc ion binding HDA PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within mitochondrial electron transport, succinate to ubiquinone ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plastid HDA PubMed 
    part_of respiratory chain complex II (succinate dehydrogenase) IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex II (succinate dehydrogenase) ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    succinate dehydrogenase 2-2
    NP_198881.1
    • succinate dehydrogenase 2-2 (SDH2-2); CONTAINS InterPro DOMAIN/s: Ferredoxin (InterPro:IPR001041), Beta-grasp fold, ferredoxin-type (InterPro:IPR012675), Fumarate reductase, C-terminal (InterPro:IPR012285), 2Fe-2S ferredoxin, iron-sulphur binding site (InterPro:IPR006058), 4Fe-4S ferredoxin, iron-sulpur binding domain (InterPro:IPR017896), 4Fe-4S ferredoxin, iron-sulphur binding, conserved site (InterPro:IPR017900), Alpha-helical ferredoxin (InterPro:IPR009051), Succinate dehydrogenase/fumarate reductase iron-sulphur protein (InterPro:IPR004489); BEST Arabidopsis thaliana protein match is: succinate dehydrogenase 2-1 (TAIR:AT3G27380.2); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      16281394..16283527
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_123430.2 → NP_198881.1  succinate dehydrogenase 2-2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_198881.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LB02, Q9FM32, Q9G3L9
      UniProtKB/TrEMBL
      A0A178UNP1, A0A5S9YC30
      Conserved Domains (1) summary
      PLN00129
      Location:1 → 280
      PLN00129; succinate dehydrogenase [ubiquinone] iron-sulfur subunit

    2. NM_001344348.1 → NP_001332094.1  succinate dehydrogenase 2-2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UNP1, A0A1P8BFU4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LB02.2

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