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    ERF1-1 eukaryotic release factor 1-1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834839, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ERF1-1
    Official Full Name
    eukaryotic release factor 1-1
    Primary source
    TAIR:AT5G47880
    Locus tag
    AT5G47880
    See related
    Araport:AT5G47880
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AteRF1-1; EUKARYOTIC RELEASE FACTOR 1; eukaryotic release factor 1-1; MCA23.22; MCA23_22
    Summary
    Encodes a eukaryotic release factor 1 homolog. Cosuppression of the gene's expression results affects cell elongation of the inflorescence stem, specifically the internodes, and radial cell division. Expression of the protein is primarily observed in the vascular system and in actively growing and elongating zones.
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    Genomic context

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    See ERF1-1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    3
    Sequence:
    Chromosome: 5; NC_003076.8 (19386045..19388587, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene CRINKLY4 related 4 Neighboring gene Gut esterase (DUF1350) Neighboring gene cobalt ion-binding protein Neighboring gene NADH-ubiquinone oxidoreductase B8 subunit Neighboring gene heparan-alpha-glucosaminide N-acetyltransferase-like protein (DUF1624)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression of the eRF1 translation termination factor is controlled by an autoregulatory circuit involving readthrough and nonsense-mediated decay in plants. Nyikó T, et al. Nucleic Acids Res, 2017 Apr 20. PMID 28062855, Free PMC Article
    2. Cosuppression of eukaryotic release factor 1-1 in Arabidopsis affects cell elongation and radial cell division. Petsch KA, et al. Plant Physiol, 2005 Sep. PMID 16113224, Free PMC Article
    3. Translation termination in Arabidopsis thaliana: characterisation of three versions of release factor 1. Chapman B, et al. Gene, 2004 Oct 27. PMID 15474304
    4. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article
    5. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. readthrough partially protects the eRF1-1 mRNA from its 3UTR induced nonsense-mediated decay (NMD), and that elevated eRF1 levels inhibit readthrough and stimulate NMD.
      Title: Expression of the eRF1 translation termination factor is controlled by an autoregulatory circuit involving readthrough and nonsense-mediated decay in plants.
    2. This is the first attempt at functional characterization of a release factor in vivo in plants and demonstrates the importance of eRF1-1 function in Arabidopsis.
      Title: Cosuppression of eukaryotic release factor 1-1 in Arabidopsis affects cell elongation and radial cell division.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001036952.1
    NM_124162.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables translation release factor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within translational termination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    eukaryotic release factor 1-1
    NP_001032029.1
    • eukaryotic release factor 1-1 (ERF1-1); FUNCTIONS IN: translation release factor activity; INVOLVED IN: translational termination; LOCATED IN: cytoplasm; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: eRF1 domain 2 (InterPro:IPR005141), eRF1 domain 3 (InterPro:IPR005142), eRF1 domain 1 (InterPro:IPR005140), Peptide chain release factor eRF1/aRF1 (InterPro:IPR004403); BEST Arabidopsis thaliana protein match is: eukaryotic release factor 1-3 (TAIR:AT3G26618.1); Has 1152 Blast hits to 1147 proteins in 383 species: Archae - 313; Bacteria - 10; Metazoa - 243; Fungi - 153; Plants - 143; Viruses - 3; Other Eukaryotes - 287 (source: NCBI BLink).
    NP_199599.1
    • eukaryotic release factor 1-1 (ERF1-1); FUNCTIONS IN: translation release factor activity; INVOLVED IN: translational termination; LOCATED IN: cytoplasm; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: eRF1 domain 2 (InterPro:IPR005141), eRF1 domain 3 (InterPro:IPR005142), eRF1 domain 1 (InterPro:IPR005140), Peptide chain release factor eRF1/aRF1 (InterPro:IPR004403); BEST Arabidopsis thaliana protein match is: eukaryotic release factor 1-3 (TAIR:AT3G26618.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      19386045..19388587 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124162.4 → NP_199599.1  eukaryotic release factor 1-1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199599.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DFT5, Q39097, Q94A12, Q9FIJ3
      UniProtKB/TrEMBL
      A0A178UFY7, A0A5S9YBX7, A0A7G2FGJ3
      Conserved Domains (1) summary
      COG1503
      Location:6 → 420
      eRF1; Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]

    2. NM_001036952.1 → NP_001032029.1  eukaryotic release factor 1-1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001032029.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DFT5, Q39097, Q94A12, Q9FIJ3
      UniProtKB/TrEMBL
      A0A178UFY7, A0A5S9YBX7, A0A7G2FGJ3
      Conserved Domains (1) summary
      COG1503
      Location:6 → 420
      eRF1; Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q39097.2

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