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    PBS2 cysteine and histidine-rich domain-containing protein RAR1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835244, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PBS2
    Official Full Name
    cysteine and histidine-rich domain-containing protein RAR1
    Primary source
    TAIR:AT5G51700
    Locus tag
    AT5G51700
    See related
    Araport:AT5G51700
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATRAR1; MIO24.17; MIO24_17; PPHB SUSCEPTIBLE 2; RAR1; Required for Mla12 resistance 1; RPR2
    Summary
    Encodes a resistance signalling protein with two zinc binding (CHORD) domains that are highly conserved across eukaryotic phyla. Mutant has reduced RPS5 and RPM1 mediated resistance. Potentially involved in transduction of R gene mediated disease resistance. Required for R protein accumulation.
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    Genomic context

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    See PBS2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    6
    Sequence:
    Chromosome: 5; NC_003076.8 (21001144..21003286, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene hydroxyproline-rich glycoprotein family protein Neighboring gene 1-amino-cyclopropane-1-carboxylate synthase 12 Neighboring gene K+ efflux antiporter 5 Neighboring gene 2 iron, 2 sulfur cluster binding protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis RAR1 exerts rate-limiting control of R gene-mediated defenses against multiple pathogens. Muskett PR, et al. Plant Cell, 2002 May. PMID 12034891, Free PMC Article
    2. RAR1 and NDR1 contribute quantitatively to disease resistance in Arabidopsis, and their relative contributions are dependent on the R gene assayed. Tornero P, et al. Plant Cell, 2002 May. PMID 12034893, Free PMC Article
    3. Biochemical characterization of RAR1 cysteine- and histidine-rich domains (CHORDs): a novel class of zinc-dependent protein-protein interaction modules. Heise CT, et al. Biochemistry, 2007 Feb 13. PMID 17279625
    4. Structural basis for assembly of Hsp90-Sgt1-CHORD protein complexes: implications for chaperoning of NLR innate immunity receptors. Zhang M, et al. Mol Cell, 2010 Jul 30. PMID 20670895, Free PMC Article
    5. The Arabidopsis gain-of-function mutant ssi4 requires RAR1 and SGT1b differentially for defense activation and morphological alterations. Zhou F, et al. Mol Plant Microbe Interact, 2008 Jan. PMID 18052881

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The induction of defence responses and disease resistance to X. campestris pv. campestris strain 8004 requires NDR1 , RAR1 and SGT1b, suggesting that effector-triggered immunity plays a large role in resistance to this strain.
      Title: Effector-triggered innate immunity contributes Arabidopsis resistance to Xanthomonas campestris.
    2. By recapitulating the activity of RAR1, these novel hsp90 alleles allow us to propose that RAR1 regulates the physical open-close cycling of a known "lid structure" that is used as a dynamic regulatory HSP90 mechanism
      Title: Specific Arabidopsis HSP90.2 alleles recapitulate RAR1 cochaperone function in plant NB-LRR disease resistance protein regulation.
    3. Genetic analysis revealed that ssi4-induced H(2)O(2) accumulation and spontaneous cell death require RAR1, whereas ssi4-mediated stunting is dependent on SGT1b.
      Title: The Arabidopsis gain-of-function mutant ssi4 requires RAR1 and SGT1b differentially for defense activation and morphological alterations.
    4. MEKK1 is essential for activation of MPK4 and negatively regulates temperature-sensitive and tissue-specific cell death and H(2)O(2) accumulation that are dependent on both RAR1 (resistance protein function) and SID2 (isochorismate synthase)
      Title: MEKK1 is required for MPK4 activation and regulates tissue-specific and temperature-dependent cell death in Arabidopsis.
    5. SGT1b antagonizes RAR1 to negatively regulate R protein accumulation before infection, and SGT1b has a RAR1-independent function that regulates programmed cell death during infection
      Title: Antagonistic control of disease resistance protein stability in the plant immune system.
    6. RAR1 molecularly links pathogen-associated molecular pattern (PAMP)-triggered immunity, effector virulence, and effector-triggered immunity
      Title: RAR1, a central player in plant immunity, is targeted by Pseudomonas syringae effector AvrB.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001344954.1
    NM_124549.8

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables Hsp90 protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in plant-type hypersensitive response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in respiratory burst involved in defense response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    cysteine and histidine-rich domain-containing protein RAR1
    NP_568762.6
    • PPHB SUSCEPTIBLE 2 (PBS2); CONTAINS InterPro DOMAIN/s: Cysteine/histidine-rich domain (InterPro:IPR007051); Has 933 Blast hits to 477 proteins in 168 species: Archae - 0; Bacteria - 18; Metazoa - 449; Fungi - 191; Plants - 188; Viruses - 0; Other Eukaryotes - 87 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      21001144..21003286 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124549.8 → NP_568762.6  cysteine and histidine-rich domain-containing protein RAR1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568762.6

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FLI9, Q9SE33
      UniProtKB/TrEMBL
      A0A5S9YD35, A0A654GA10
      Conserved Domains (1) summary
      pfam04968
      Location:157 → 218
      CHORD

    2. NM_001344954.1 → NP_001331373.1  cysteine and histidine-rich domain-containing protein RAR1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UE66, A0A1P8BDN4, A0A384KZD9, A0A654GA10
      Conserved Domains (1) summary
      pfam04968
      Location:114 → 175
      CHORD
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SE33.1

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