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    RCAR3 regulatory components of ABA receptor 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835397, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RCAR3
    Official Full Name
    regulatory components of ABA receptor 3
    Primary source
    TAIR:AT5G53160
    Locus tag
    AT5G53160
    See related
    Araport:AT5G53160
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MFH8.10; MFH8_10; PYL8; PYR1-like 8; regulatory components of ABA receptor 3
    Summary
    Encodes RCAR3, a regulatory component of ABA receptor. Interacts with protein phosphatase 2Cs ABI1 and ABI2. Stimulates ABA signaling.
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    Genomic context

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    See RCAR3 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    3
    Sequence:
    Chromosome: 5; NC_003076.8 (21560601..21562709)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock amino-terminal domain protein Neighboring gene ncRNA Neighboring gene FTSH protease 11 Neighboring gene polypyrimidine tract-binding protein 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PYL8 mediates ABA perception in the root through non-cell-autonomous and ligand-stabilization-based mechanisms. Belda-Palazon B, et al. Proc Natl Acad Sci U S A, 2018 Dec 11. PMID 30482863, Free PMC Article
    2. Abscisic acid receptor PYRABACTIN RESISTANCE-LIKE 8, PYL8, is involved in glucose response and dark-induced leaf senescence in Arabidopsis. Lee HN, et al. Biochem Biophys Res Commun, 2015 Jul 17-24. PMID 25983319
    3. PHYTOCHROME-INTERACTING FACTORS Interact with the ABA Receptors PYL8 and PYL9 to Orchestrate ABA Signaling in Darkness. Qi L, et al. Mol Plant, 2020 Mar 2. PMID 32059872
    4. The ABA receptor PYL9 together with PYL8 plays an important role in regulating lateral root growth. Xing L, et al. Sci Rep, 2016 Jun 3. PMID 27256015, Free PMC Article
    5. The nuclear interactor PYL8/RCAR3 of Fagus sylvatica FsPP2C1 is a positive regulator of abscisic acid signaling in seeds and stress. Saavedra X, et al. Plant Physiol, 2010 Jan. PMID 19889877, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PHYTOCHROME-INTERACTING FACTORS Interact with the ABA Receptors PYL8 and PYL9 to Orchestrate ABA Signaling in Darkness.
      Title: PHYTOCHROME-INTERACTING FACTORS Interact with the ABA Receptors PYL8 and PYL9 to Orchestrate ABA Signaling in Darkness.
    2. The PYL8 transcript was detected in the epidermis and stele of the root meristem; however, the PYL8 protein was also detected in adjacent tissues. Expression of PYL8 driven by tissue-specific promoters revealed movement to adjacent tissues. Hence both inter- and intracellular trafficking of PYL8 appears to occur in the root apical meristem.
      Title: PYL8 mediates ABA perception in the root through non-cell-autonomous and ligand-stabilization-based mechanisms.
    3. Results confirm that PYL8 plays an important role in regulating lateral root growth of aeabidopsis.
      Title: The ABA receptor PYL9 together with PYL8 plays an important role in regulating lateral root growth.
    4. RIFP1 plays a negative role in the RCAR3-mediated abscissic acid signalling pathway.
      Title: The Arabidopsis F-box E3 ligase RIFP1 plays a negative role in abscisic acid signalling by facilitating ABA receptor RCAR3 degradation.
    5. Overexpression of PYL8 resulted in significantly reduced seed germination and cotyledon greening under high glucose conditions, while RNAi transgenic lines were more insensitive to glucose stress.
      Title: Abscisic acid receptor PYRABACTIN RESISTANCE-LIKE 8, PYL8, is involved in glucose response and dark-induced leaf senescence in Arabidopsis.
    6. The ABA receptor PYL8 promotes lateral root growth by enhancing MYB77-dependent transcription of auxin-responsive genes.
      Title: The ABA receptor PYL8 promotes lateral root growth by enhancing MYB77-dependent transcription of auxin-responsive genes.
    7. Data indicate that PYL8 interacted in vivo with at least five PP2Cs, namely HAB1, HAB2, ABI1, ABI2, and PP2CA.
      Title: PYRABACTIN RESISTANCE1-LIKE8 plays an important role for the regulation of abscisic acid signaling in root.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_124695.4
    NM_180849.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables abscisic acid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein phosphatase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within abscisic acid-activated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in abscisic acid-activated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of abscisic acid-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to abscisic acid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    regulatory components of ABA receptor 3
    NP_200128.1
    • regulatory components of ABA receptor 3 (RCAR3); CONTAINS InterPro DOMAIN/s: Polyketide cyclase/dehydrase (InterPro:IPR019587); BEST Arabidopsis thaliana protein match is: regulatory component of ABA receptor 1 (TAIR:AT1G01360.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).
    NP_851180.1
    • regulatory components of ABA receptor 3 (RCAR3); CONTAINS InterPro DOMAIN/s: Polyketide cyclase/dehydrase (InterPro:IPR019587); BEST Arabidopsis thaliana protein match is: PYR1-like 10 (TAIR:AT4G27920.1); Has 397 Blast hits to 397 proteins in 25 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 397; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      21560601..21562709
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124695.4 → NP_200128.1  regulatory components of ABA receptor 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200128.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WRI3, Q9FGM1
      UniProtKB/TrEMBL
      A0A178UJN3, A0A5S9YDP8
      Conserved Domains (1) summary
      cd07821
      Location:32 → 176
      PYR_PYL_RCAR_like; Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins

    2. NM_180849.2 → NP_851180.1  regulatory components of ABA receptor 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851180.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4KJ16
      Conserved Domains (1) summary
      cd07821
      Location:32 → 118
      PYR_PYL_RCAR_like; Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FGM1.1

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