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    ADCL D-aminoacid aminotransferase-like PLP-dependent enzymes superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835895, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ADCL
    Official Full Name
    D-aminoacid aminotransferase-like PLP-dependent enzymes superfamily protein
    Primary source
    TAIR:AT5G57850
    Locus tag
    AT5G57850
    See related
    Araport:AT5G57850
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    4-amino-4-deoxychorismate lyase; MTI20.10; MTI20_10
    Summary
    ADCL encodes a protein that acts as a 4-amino-4-deoxychorismate lyase. It catalyzes the production 4-aminobenzoate (pABA) production which is required for folate biosynthesis. The enzyme localizes to chloroplasts based on an import assay and GFP localization experiments.
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    Genomic context

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    See ADCL in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    5
    Sequence:
    Chromosome: 5; NC_003076.8 (23435291..23437347, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene HXXXD-type acyl-transferase family protein Neighboring gene Ubiquitin-like superfamily protein Neighboring gene MIF4G domain-containing protein / MA3 domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AtDAT1 Is a Key Enzyme of D-Amino Acid Stimulated Ethylene Production in Arabidopsis thaliana. Suarez J, et al. Front Plant Sci, 2019. PMID 31921255, Free PMC Article
    2. Folate synthesis in plants: the last step of the p-aminobenzoate branch is catalyzed by a plastidial aminodeoxychorismate lyase. Basset GJ, et al. Plant J, 2004 Nov. PMID 15500462
    3. AT_CHLORO, a comprehensive chloroplast proteome database with subplastidial localization and curated information on envelope proteins. Ferro M, et al. Mol Cell Proteomics, 2010 Jun. PMID 20061580, Free PMC Article
    4. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article
    5. Sorting signals, N-terminal modifications and abundance of the chloroplast proteome. Zybailov B, et al. PLoS One, 2008 Apr 23. PMID 18431481, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The full-length Arabidopsis ADC lyase polypeptide was translocated into isolated pea chloroplasts and directed the passenger protein to Arabidopsis chloroplasts. [ADC lyase]
      Title: Folate synthesis in plants: the last step of the p-aminobenzoate branch is catalyzed by a plastidial aminodeoxychorismate lyase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_001345276.1
    NM_125170.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 4-amino-4-deoxychorismate lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 4-amino-4-deoxychorismate lyase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables D-alanine-2-oxoglutarate aminotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within para-aminobenzoic acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tetrahydrofolate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tetrahydrofolate biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast stroma HDA PubMed 

    General protein information

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    Preferred Names
    D-aminoacid aminotransferase-like PLP-dependent enzymes superfamily protein
    NP_200593.2
    • D-aminoacid aminotransferase-like PLP-dependent enzymes superfamily protein; FUNCTIONS IN: 4-amino-4-deoxychorismate lyase activity, catalytic activity; INVOLVED IN: tetrahydrofolate biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Aminotransferase, class IV (InterPro:IPR001544); BEST Arabidopsis thaliana protein match is: D-aminoacid aminotransferase-like PLP-dependent enzymes superfamily protein (TAIR:AT3G05190.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      23435291..23437347 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125170.5 → NP_200593.2  D-aminoacid aminotransferase-like PLP-dependent enzymes superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200593.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8L493, Q9FJM9
      UniProtKB/TrEMBL
      A0A178UUA2, A0A5S9YF52, Q0WW83
      Conserved Domains (1) summary
      PLN02845
      Location:43 → 373
      PLN02845; Branched-chain-amino-acid aminotransferase-like protein

    2. NM_001345276.1 → NP_001330897.1  D-aminoacid aminotransferase-like PLP-dependent enzymes superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BC80, A0A7G2FNC3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8L493.1

    Gene LinkOut

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