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    EXO70B1 exocyst subunit exo70 family protein B1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835956, updated on 18-Sep-2024

    Summary

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    Official Symbol
    EXO70B1
    Official Full Name
    exocyst subunit exo70 family protein B1
    Primary source
    TAIR:AT5G58430
    Locus tag
    AT5G58430
    See related
    Araport:AT5G58430
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATEXO70B1; exocyst subunit exo70 family protein B1; MQJ2.2; MQJ2_2
    Summary
    A member of EXO70 gene family, putative exocyst subunits, conserved in land plants. Arabidopsis thaliana contains 23 putative EXO70 genes, which can be classified into eight clusters on the phylogenetic tree.
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    Genomic context

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    See EXO70B1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    1
    Sequence:
    Chromosome: 5; NC_003076.8 (23621152..23623543, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Putative membrane lipoprotein Neighboring gene Ribosomal protein S4 (RPS4A) family protein Neighboring gene sorting nexin 2A Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene cation/H+ exchanger 25

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Pseudomonas Syringae Effector AvrPtoB Associates With and Ubiquitinates Arabidopsis Exocyst Subunit EXO70B1. Wang W, et al. Front Plant Sci, 2019. PMID 31555308, Free PMC Article
    2. The exocyst subunit Exo70B1 is involved in the immune response of Arabidopsis thaliana to different pathogens and cell death. Stegmann M, et al. Plant Signal Behav, 2013. PMID 24389869, Free PMC Article
    3. The Arabidopsis exocyst subunits EXO70B1 and EXO70B2 regulate FLS2 homeostasis at the plasma membrane. Wang W, et al. New Phytol, 2020 Jul. PMID 32119118
    4. CALCIUM-DEPENDENT PROTEIN KINASE5 Associates with the Truncated NLR Protein TIR-NBS2 to Contribute to exo70B1-Mediated Immunity. Liu N, et al. Plant Cell, 2017 Apr. PMID 28351987, Free PMC Article
    5. CAMTA3 repressor destabilization triggers TIR domain protein TN2-mediated autoimmunity in the Arabidopsis exo70B1 mutant. Liu N, et al. Plant Cell, 2024 May 1. PMID 38309956,

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CAMTA3 repressor destabilization triggers TIR domain protein TN2-mediated autoimmunity in the Arabidopsis exo70B1 mutant.
      Title: CAMTA3 repressor destabilization triggers TIR domain protein TN2-mediated autoimmunity in the Arabidopsis exo70B1 mutant.
    2. The Arabidopsis exocyst subunits EXO70B1 and EXO70B2 regulate FLS2 homeostasis at the plasma membrane.
      Title: The Arabidopsis exocyst subunits EXO70B1 and EXO70B2 regulate FLS2 homeostasis at the plasma membrane.
    3. Transiently expressed RIN4, but not the plasma membrane (PM) protein aquaporin PIP2, recruits EXO70B1 to the plasma membrane (PM). Unlike EXO70B1, RIN4 does not recruit the core exocyst subunit SEC6 to the PM under these conditions.
      Title: RIN4 recruits the exocyst subunit EXO70B1 to the plasma membrane.
    4. The work uncovers a direct functional link between an atypical immune receptor and a crucial component of early immune signaling: increased immunity in exo70B1 depends on TN2 and CPK5 and, in a positive feedback loop, TN2 keeps CPK5 enzymatically active beyond the initiating stimulus.
      Title: CALCIUM-DEPENDENT PROTEIN KINASE5 Associates with the Truncated NLR Protein TIR-NBS2 to Contribute to exo70B1-Mediated Immunity.
    5. ROP2 and RIC7 suppress excess stomatal opening by inhibiting Exo70B1.
      Title: The ROP2-RIC7 pathway negatively regulates light-induced stomatal opening by inhibiting exocyst subunit Exo70B1 in Arabidopsis.
    6. Our data are consistent with a speculative model wherein pathogen effectors could evolve to target EXO70B1 to manipulate plant secretion machinery. TN2 could monitor EXO70B1 integrity as part of an immune receptor complex
      Title: A truncated NLR protein, TIR-NBS2, is required for activated defense responses in the exo70B1 mutant.
    7. exo70B1 mutants display pathogen-specific immuno-compromised phenotypes.
      Title: The exocyst subunit Exo70B1 is involved in the immune response of Arabidopsis thaliana to different pathogens and cell death.
    8. Vesicular trafficking of anthocyanins into the vacuole is compromised in exo70B1-2 mutant.
      Title: Arabidopsis exocyst subcomplex containing subunit EXO70B1 is involved in autophagy-related transport to the vacuole.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_125229.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables phosphatidylinositol-4,5-bisphosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response by callose deposition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of lateral root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of abscisic acid-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of stomatal closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to water deprivation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of exocyst IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in extracellular exosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    exocyst subunit exo70 family protein B1
    NP_200651.1
    • exocyst subunit exo70 family protein B1 (EXO70B1); INVOLVED IN: exocytosis, vesicle docking involved in exocytosis; LOCATED IN: plasma membrane, exocyst; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Exo70 exocyst complex subunit (InterPro:IPR004140); BEST Arabidopsis thaliana protein match is: exocyst subunit exo70 family protein B2 (TAIR:AT1G07000.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      23621152..23623543 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125229.4 → NP_200651.1  exocyst subunit exo70 family protein B1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200651.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FGH9
      UniProtKB/TrEMBL
      A0A178UIU4, A0A5S9YFE1
      Conserved Domains (1) summary
      pfam03081
      Location:266 → 614
      Exo70; Exo70 exocyst complex subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FGH9.1

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