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    COB COBRA-like extracellular glycosyl-phosphatidyl inositol-anchored protein family [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836213, updated on 18-Sep-2024

    Summary

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    Official Symbol
    COB
    Official Full Name
    COBRA-like extracellular glycosyl-phosphatidyl inositol-anchored protein family
    Primary source
    TAIR:AT5G60920
    Locus tag
    AT5G60920
    See related
    Araport:AT5G60920
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    COBRA; MSL3.40; MSL3_40
    Summary
    Encodes a glycosylphosphatidylinositol-anchored protein localized primarily in the plasma membrane of the longitudinal sides of root cells. Necessary for oriented cell expansion in Arabidopsis. Cob mutants have abnormal roots that expand radially rather than longitudinally under certain growth conditions.
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    Genomic context

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    See COB in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    7
    Sequence:
    Chromosome: 5; NC_003076.8 (24511152..24514338, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene receptor-like protein kinase 1 Neighboring gene AGAMOUS-like 8 Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene Transducin/WD40 repeat-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cell identity mediates the response of Arabidopsis roots to abiotic stress. Dinneny JR, et al. Science, 2008 May 16. PMID 18436742
    2. Loss of function of COBRA, a determinant of oriented cell expansion, invokes cellular defence responses in Arabidopsis thaliana. Ko JH, et al. J Exp Bot, 2006. PMID 16873454
    3. Establishing and maintaining axial growth: wall mechanical properties and the cytoskeleton. Wasteneys GO, et al. J Plant Res, 2006 Jan. PMID 16284708
    4. COBRA encodes a putative GPI-anchored protein, which is polarly localized and necessary for oriented cell expansion in Arabidopsis. Schindelman G, et al. Genes Dev, 2001 May 1. PMID 11331607, Free PMC Article
    5. Identification of MEDIATOR16 as the Arabidopsis COBRA suppressor MONGOOSE1. Sorek N, et al. Proc Natl Acad Sci U S A, 2015 Dec 29. PMID 26655738, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that mutations in MEDIATOR16 (MED16) reduce the number of misregulated genes in cobra (cob-6) mutants and suppress the phenotypes.
      Title: Identification of MEDIATOR16 as the Arabidopsis COBRA suppressor MONGOOSE1.
    2. COBRA's function in maintaining anisotropic expansion may be microtubule-dependent.
      Title: Establishing and maintaining axial growth: wall mechanical properties and the cytoskeleton.
    3. Mutations within the COBRA gene that result in a loss of function result in abnormal cell growth throughout the entire plant body and the accumulation of massive amounts of stress response chemicals such as anthocyanins and callose.
      Title: Loss of function of COBRA, a determinant of oriented cell expansion, invokes cellular defence responses in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001345435.1
    NM_125485.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellulose microfibril organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellulose microfibril organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multidimensional cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in longitudinal side of cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in plant-type cell wall IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    COBRA-like extracellular glycosyl-phosphatidyl inositol-anchored protein family
    NP_568930.1
    • COBRA (COB); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: response to salt stress, multidimensional cell growth, cellulose microfibril organization; LOCATED IN: in 6 components; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Glycosyl-phosphatidyl inositol-anchored, plant (InterPro:IPR006918), COBRA-like (InterPro:IPR017391); BEST Arabidopsis thaliana protein match is: COBRA-like protein 1 precursor (TAIR:AT3G02210.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      24511152..24514338 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125485.4 → NP_568930.1  COBRA-like extracellular glycosyl-phosphatidyl inositol-anchored protein family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568930.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81811, Q8LDZ4, Q94KT8
      UniProtKB/TrEMBL
      A0A178UFZ7, A0A5S9YG34
      Conserved Domains (1) summary
      pfam04833
      Location:60 → 223
      COBRA; COBRA-like protein

    2. NM_001345435.1 → NP_001330939.1  COBRA-like extracellular glycosyl-phosphatidyl inositol-anchored protein family [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BCB5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94KT8.1

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