HSF4 heat shock factor 4 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: HSF4
Official Full Name: heat shock factor 4
Primary source: TAIR:AT4G36990
Locus tag: AT4G36990
See related: Araport:AT4G36990
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AP22.9; AP22_9; ARABIDOPSIS THALIANA CLASS B HEAT SHOCK FACTOR B1; ARABIDOPSIS THALIANA HEAT SHOCK FACTOR 4; AT-HSFB1; ATHSF4; CLASS B HEAT SHOCK FACTOR B1; heat shock factor 4; HSFB1; TBF1; TL1-binding transcription factor 1
Summary: Encodes a protein whose sequence is similar to heat shock factors that regulate the expression of heat shock proteins. Transcript level is increased in response to heat shock. However, overexpression of this gene did not result in the increase of decrease of heat shock proteins.
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Genomic context

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See HSF4 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 2

Sequence:: Chromosome: 4; NC_003075.7 (17440177..17442151)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HEAT SHOCK FACTOR B1 (HsfB1) degradation is mediated by its transcriptional repressor function.
Title: DNA-binding and repressor function are prerequisites for the turnover of the tomato heat stress transcription factor HsfB1.
through a unique regulatory mechanism, TBF1 can sense the metabolic changes upon pathogen invasion and trigger the specific transcriptional reprogramming through its target genes expression [TBF1]
Title: The HSF-like transcription factor TBF1 is a major molecular switch for plant growth-to-defense transition.
Data indicate that cngc16 mutant pollen have attenuated expression of several heat-stress response genes, including two heat shock transcription factor genes, HsfA2 and HsfB1.
Title: A cyclic nucleotide-gated channel (CNGC16) in pollen is critical for stress tolerance in pollen reproductive development.
HsfB1 has a post-transcriptional control mechanism, in which a sequence-conserved upstream open-reading frame (sc-uORF) is involved.
Title: An inhibitory effect of the sequence-conserved upstream open-reading frame on the translation of the main open-reading frame of HsfB1 transcripts in Arabidopsis.
HsfB1 is required for the primed expression of defense-related genes.
Title: Heat shock factor HsfB1 primes gene transcription and systemic acquired resistance in Arabidopsis.
These data indicate that HsfB1 and HsfB2b suppress the general heat shock response under non-heat-stress conditions and in the attenuating period.
Title: Arabidopsis HsfB1 and HsfB2b act as repressors of the expression of heat-inducible Hsfs but positively regulate the acquired thermotolerance.
Data suggest that HsfB1 and HsfB2b may be involved in complex regulatory networks, which are linked to other stress responses and signaling processes.
Title: Detection of in vivo interactions between Arabidopsis class A-HSFs, using a novel BiFC fragment, and identification of novel class B-HSF interacting proteins.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Miscellaneous features

Loc: 17440443-17440553 AT4G36990.uORF1

NM_119862.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within priming of cellular response to stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to heat	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: heat shock factor 4

NP_195416.1

heat shock factor 4 (HSF4); FUNCTIONS IN: transcription repressor activity, DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: response to cyclopentenone, response to heat; LOCATED IN: nucleus; CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), Heat shock factor (HSF)-type, DNA-binding (InterPro:IPR000232); BEST Arabidopsis thaliana protein match is: heat shock transcription factor B2A (TAIR:AT5G62020.1); Has 2101 Blast hits to 2087 proteins in 226 species: Archae - 0; Bacteria - 2; Metazoa - 340; Fungi - 475; Plants - 774; Viruses - 0; Other Eukaryotes - 510 (source: NCBI BLink).