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    Map3k15 mitogen-activated protein kinase kinase kinase 15 [ Mus musculus (house mouse) ]

    Gene ID: 270672, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Map3k15provided by MGI
    Official Full Name
    mitogen-activated protein kinase kinase kinase 15provided by MGI
    Primary source
    MGI:MGI:2448588
    See related
    Ensembl:ENSMUSG00000031303 AllianceGenome:MGI:2448588
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MEKK15
    Summary
    Predicted to enable MAP kinase kinase kinase activity. Predicted to be involved in JNK cascade and p38MAPK cascade. Is expressed in pancreas. Orthologous to human MAP3K15 (mitogen-activated protein kinase kinase kinase 15). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in heart adult (RPKM 24.0), kidney adult (RPKM 12.9) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Map3k15 in Genome Data Viewer
    Location:
    X F4; X 73.95 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (158771200..158906342)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (159988204..160123346)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene Bclaf1 and Thrap3 family member 3 Neighboring gene predicted gene 15186 Neighboring gene STARR-positive B cell enhancer mm9_chrX:156088144-156088445 Neighboring gene SH3-domain kinase binding protein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:156134996-156135149 Neighboring gene STARR-seq mESC enhancer starr_48175 Neighboring gene cofilin 1, non-muscle pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7710 Neighboring gene STARR-seq mESC enhancer starr_48178 Neighboring gene predicted gene, 39547 Neighboring gene pyruvate dehydrogenase E1 alpha 1 Neighboring gene STARR-seq mESC enhancer starr_48179 Neighboring gene STARR-seq mESC enhancer starr_48180 Neighboring gene predicted gene 15195

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Crucial role for CA2 inputs in the sequential organization of CA1 time cells supporting memory. MacDonald CJ, et al. Proc Natl Acad Sci U S A, 2021 Jan 19. PMID 33431691, Free PMC Article
    2. Ventral CA1 neurons store social memory. Okuyama T, et al. Science, 2016 Sep 30. PMID 27708103, Free PMC Article
    3. Cell type-specific genetic and optogenetic tools reveal hippocampal CA2 circuits. Kohara K, et al. Nat Neurosci, 2014 Feb. PMID 24336151, Free PMC Article
    4. ASK3 responds to osmotic stress and regulates blood pressure by suppressing WNK1-SPAK/OSR1 signaling in the kidney. Naguro I, et al. Nat Commun, 2012. PMID 23250415
    5. ASK family kinases mediate cellular stress and redox signaling to circadian clock. Imamura K, et al. Proc Natl Acad Sci U S A, 2018 Apr 3. PMID 29555767, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables JUN kinase kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MAP kinase kinase kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables MAP kinase kinase kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in p38MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mitogen-activated protein kinase kinase kinase 15
    Names
    MAPK/ERK kinase kinase 15
    MEK kinase 15
    NP_001156557.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163085.4 → NP_001156557.2  mitogen-activated protein kinase kinase kinase 15

      See identical proteins and their annotated locations for NP_001156557.2

      Status: VALIDATED

      Source sequence(s)
      AL845167, AL929452
      Consensus CDS
      CCDS53236.1
      UniProtKB/Swiss-Prot
      A2AQW0
      Related
      ENSMUSP00000033665.9, ENSMUST00000033665.9
      Conserved Domains (3) summary
      smart00220
      Location:661 → 912
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06624
      Location:647 → 912
      STKc_ASK; Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase
      pfam13281
      Location:140 → 518
      DUF4071; Domain of unknown function (DUF4071)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      158771200..158906342
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2AQW0.1 GenPept UniProtKB/Swiss-Prot:A2AQW0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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