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    Scaper S phase cyclin A-associated protein in the ER [ Mus musculus (house mouse) ]

    Gene ID: 244891, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Scaperprovided by MGI
    Official Full Name
    S phase cyclin A-associated protein in the ERprovided by MGI
    Primary source
    MGI:MGI:1925976
    See related
    Ensembl:ENSMUSG00000034007 AllianceGenome:MGI:1925976
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfp291; C430017I08; D530014O03Rik
    Summary
    Acts upstream of or within antral ovarian follicle growth; seminiferous tubule development; and spermatogenesis. Located in nucleus; ooplasm; and sperm head. Is expressed in brain; early conceptus; eye; and genitourinary system. Orthologous to human SCAPER (S-phase cyclin A associated protein in the ER). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 5.9), CNS E18 (RPKM 5.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Scaper in Genome Data Viewer
    Location:
    9 B; 9 30.13 cM
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (55457163..55845505, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (55549879..55938221, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24191 Neighboring gene STARR-seq mESC enhancer starr_24192 Neighboring gene predicted gene 5917 Neighboring gene predicted gene, 23407 Neighboring gene insulin related protein 2 (islet 2) Neighboring gene STARR-seq mESC enhancer starr_24193 Neighboring gene ribosomal protein L13 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr9:55546201-55546502 Neighboring gene predicted gene, 39342 Neighboring gene STARR-seq mESC enhancer starr_24195 Neighboring gene STARR-positive B cell enhancer ABC_E6735 Neighboring gene STARR-seq mESC enhancer starr_24197 Neighboring gene RIKEN cDNA 4930563M21 gene Neighboring gene ring finger protein 19A pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Male sterility and reduced female fertility in SCAPER-deficient mice. Tatour Y, et al. Hum Mol Genet, 2020 Aug 3. PMID 32510560
    2. Mutations in SCAPER cause autosomal recessive retinitis pigmentosa with intellectual disability. Tatour Y, et al. J Med Genet, 2017 Sep 18. PMID 28794130
    3. Sonic hedgehog signaling regulates actin cytoskeleton via Tiam1-Rac1 cascade during spine formation. Sasaki N, et al. Mol Cell Neurosci, 2010 Dec. PMID 20654717
    4. Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. Mulligan MK, et al. Proc Natl Acad Sci U S A, 2006 Apr 18. PMID 16618939, Free PMC Article
    5. A neurogenomics approach to gene expression analysis in the developing brain. Jensen P, et al. Brain Res Mol Brain Res, 2004 Dec 20. PMID 15582152

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Male sterility and reduced female fertility in SCAPER-deficient mice.
      Title: Male sterility and reduced female fertility in SCAPER-deficient mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within antral ovarian follicle growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ovarian follicle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within retina development in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within seminiferous tubule development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ooplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sperm head IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    S phase cyclin A-associated protein in the endoplasmic reticulum
    Names
    zinc finger protein 291

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081341.2 → NP_001074810.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform 1

      See identical proteins and their annotated locations for NP_001074810.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC107819, AC116699, AC159901, AC164972, CT025567
      Consensus CDS
      CCDS52802.1
      UniProtKB/TrEMBL
      F8VQ70, Q69ZJ3
      Related
      ENSMUSP00000149750.2, ENSMUST00000217647.2
      Conserved Domains (2) summary
      PTZ00121
      Location:536 → 910
      PTZ00121; MAEBL; Provisional
      pfam16501
      Location:89 → 185
      SCAPER_N; S phase cyclin A-associated protein in the endoplasmic reticulum

    2. NM_001357652.1 → NP_001344581.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC107819, AC116699, AC159901, AC164972, CT025567
      Consensus CDS
      CCDS90576.1
      UniProtKB/TrEMBL
      B2RXS3, Q69ZJ3
      Related
      ENSMUSP00000149050.2, ENSMUST00000214747.2
      Conserved Domains (2) summary
      PTZ00121
      Location:530 → 904
      PTZ00121; MAEBL; Provisional
      pfam16501
      Location:89 → 185
      SCAPER_N; S phase cyclin A-associated protein in the endoplasmic reticulum

    3. NM_001357653.1 → NP_001344582.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC116699, AK021288
      UniProtKB/TrEMBL
      Q8C1F7

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      55457163..55845505 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244383.1 → XP_030100243.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X2

      UniProtKB/TrEMBL
      B2RXS3, Q69ZJ3
      Conserved Domains (2) summary
      PTZ00121
      Location:530 → 904
      PTZ00121; MAEBL; Provisional
      pfam16501
      Location:89 → 185
      SCAPER_N; S phase cyclin A-associated protein in the endoplasmic reticulum

    2. XM_011242747.3 → XP_011241049.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X1

      See identical proteins and their annotated locations for XP_011241049.1

      UniProtKB/TrEMBL
      F8VQ70, Q69ZJ3
      Conserved Domains (2) summary
      PTZ00121
      Location:536 → 910
      PTZ00121; MAEBL; Provisional
      pfam16501
      Location:89 → 185
      SCAPER_N; S phase cyclin A-associated protein in the endoplasmic reticulum

    3. XM_030244384.1 → XP_030100244.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X2

      UniProtKB/TrEMBL
      B2RXS3, Q69ZJ3
      Conserved Domains (2) summary
      PTZ00121
      Location:530 → 904
      PTZ00121; MAEBL; Provisional
      pfam16501
      Location:89 → 185
      SCAPER_N; S phase cyclin A-associated protein in the endoplasmic reticulum

    4. XM_011242748.4 → XP_011241050.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X1

      See identical proteins and their annotated locations for XP_011241050.1

      UniProtKB/TrEMBL
      F8VQ70, Q69ZJ3
      Conserved Domains (2) summary
      PTZ00121
      Location:536 → 910
      PTZ00121; MAEBL; Provisional
      pfam16501
      Location:89 → 185
      SCAPER_N; S phase cyclin A-associated protein in the endoplasmic reticulum

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_175536.2: Suppressed sequence

      Description
      NM_175536.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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