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    Fut10 fucosyltransferase 10 [ Mus musculus (house mouse) ]

    Gene ID: 171167, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fut10provided by MGI
    Official Full Name
    fucosyltransferase 10provided by MGI
    Primary source
    MGI:MGI:2384748
    See related
    Ensembl:ENSMUSG00000046152 AllianceGenome:MGI:2384748
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    fuc-TX; fut10A
    Summary
    Enables alpha-(1->3)-fucosyltransferase activity. Involved in N-glycan fucosylation; neuronal stem cell division; and oligosaccharide biosynthetic process. Acts upstream of or within cerebral cortex radially oriented cell migration; neuroblast migration; and neuronal stem cell population maintenance. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and nucleoplasm. Is expressed in central nervous system and retina. Orthologous to human FUT10 (fucosyltransferase 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 2.1), limb E14.5 (RPKM 2.1) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fut10 in Genome Data Viewer
    Location:
    8 A3; 8 18.1 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (31677342..31757310)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (31187313..31265284)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E557 Neighboring gene small nucleolar RNA, C/D box 13 Neighboring gene TELO2 interacting protein 2 Neighboring gene MAK16 homolog Neighboring gene SUMO-conjugating enzyme UBC9 pseudogene Neighboring gene eukaryotic translation initiation factor 3, subunit H pseudogene Neighboring gene RIKEN cDNA 7420700N18 gene Neighboring gene discs, large homolog-associated protein 5 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CircRNA FUT10 regulates the regenerative potential of aged skeletal muscle stem cells by targeting HOXA9. Zhu M, et al. Aging (Albany NY), 2021 Jul 13. PMID 34257163, Free PMC Article
    2. The Lewis X-related α1,3-fucosyltransferase, Fut10, is required for the maintenance of stem cell populations. Kumar A, et al. J Biol Chem, 2013 Oct 4. PMID 23986452, Free PMC Article
    3. Activity, splice variants, conserved peptide motifs, and phylogeny of two new alpha1,3-fucosyltransferase families (FUT10 and FUT11). Mollicone R, et al. J Biol Chem, 2009 Feb 13. PMID 19088067
    4. Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism. Roos C, et al. J Biol Chem, 2002 Feb 1. PMID 11698403
    5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CircRNA FUT10 regulates the regenerative potential of aged skeletal muscle stem cells by targeting HOXA9.
      Title: CircRNA FUT10 regulates the regenerative potential of aged skeletal muscle stem cells by targeting HOXA9.
    2. Fut10 is involved in a unique alpha1,3-fucosyltransferase activity with stringent substrate specificity.
      Title: The Lewis X-related α1,3-fucosyltransferase, Fut10, is required for the maintenance of stem cell populations.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC40819

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-(1->3)-fucosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-(1->3)-fucosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fucosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-glycan fucosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in N-glycan fucosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cerebral cortex radially oriented cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fucosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neuroblast migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuronal stem cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuronal stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oligosaccharide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    alpha-(1,3)-fucosyltransferase 10
    Names
    fucosyltransferase X
    galactoside 3-L-fucosyltransferase 10
    NP_001012535.1
    NP_001273351.1
    NP_001273353.1
    NP_001273354.1
    NP_598922.1
    XP_030099189.1
    XP_036009676.1
    XP_036009677.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012517.6 → NP_001012535.1  alpha-(1,3)-fucosyltransferase 10 isoform a

      See identical proteins and their annotated locations for NP_001012535.1

      Status: VALIDATED

      Source sequence(s)
      AC115775
      Consensus CDS
      CCDS22223.1
      UniProtKB/Swiss-Prot
      Q5F2L2, Q8C457, Q8K0S3, Q8R247
      Related
      ENSMUSP00000069816.6, ENSMUST00000066173.12
      Conserved Domains (2) summary
      pfam00852
      Location:219 → 354
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:82 → 177
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    2. NM_001286422.2 → NP_001273351.1  alpha-(1,3)-fucosyltransferase 10 isoform a

      See identical proteins and their annotated locations for NP_001273351.1

      Status: VALIDATED

      Source sequence(s)
      AC115775
      Consensus CDS
      CCDS22223.1
      UniProtKB/Swiss-Prot
      Q5F2L2, Q8C457, Q8K0S3, Q8R247
      Related
      ENSMUSP00000125265.2, ENSMUST00000161502.2
      Conserved Domains (2) summary
      pfam00852
      Location:219 → 354
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:82 → 177
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    3. NM_001286424.2 → NP_001273353.1  alpha-(1,3)-fucosyltransferase 10 isoform b

      See identical proteins and their annotated locations for NP_001273353.1

      Status: VALIDATED

      Source sequence(s)
      AC115775
      Consensus CDS
      CCDS52536.1
      UniProtKB/Swiss-Prot
      Q5F2L2
      Conserved Domains (2) summary
      pfam00852
      Location:219 → 354
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:82 → 177
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    4. NM_001286425.2 → NP_001273354.1  alpha-(1,3)-fucosyltransferase 10 isoform c

      See identical proteins and their annotated locations for NP_001273354.1

      Status: VALIDATED

      Source sequence(s)
      AC115775
      Consensus CDS
      CCDS72111.1
      UniProtKB/Swiss-Prot
      Q5F2L2
      Related
      ENSMUSP00000106156.3, ENSMUST00000110527.9

    5. NM_134161.4 → NP_598922.1  alpha-(1,3)-fucosyltransferase 10 isoform b

      See identical proteins and their annotated locations for NP_598922.1

      Status: VALIDATED

      Source sequence(s)
      AC115775
      Consensus CDS
      CCDS52536.1
      UniProtKB/Swiss-Prot
      Q5F2L2
      Related
      ENSMUSP00000124437.2, ENSMUST00000161788.8
      Conserved Domains (2) summary
      pfam00852
      Location:219 → 354
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:82 → 177
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      31677342..31757310
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153783.1 → XP_036009676.1  alpha-(1,3)-fucosyltransferase 10 isoform X2

      Conserved Domains (1) summary
      pfam00852
      Location:1 → 120
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term

    2. XM_030243329.2 → XP_030099189.1  alpha-(1,3)-fucosyltransferase 10 isoform X1

      UniProtKB/Swiss-Prot
      Q5F2L2, Q8C457, Q8K0S3, Q8R247
      Conserved Domains (2) summary
      pfam00852
      Location:219 → 354
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:82 → 177
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    3. XM_036153784.1 → XP_036009677.1  alpha-(1,3)-fucosyltransferase 10 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5F2L2.1 GenPept UniProtKB/Swiss-Prot:Q5F2L2

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