Slc20a2 solute carrier family 20, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc20a2provided by MGI
Official Full Name: solute carrier family 20, member 2provided by MGI
Primary source: MGI:MGI:97851
See related: Ensembl:ENSMUSG00000037656 AllianceGenome:MGI:97851
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pit2; Ram1; Pit-2; Ram-1; MolPit2
Summary: Enables sodium:phosphate symporter activity. Involved in positive regulation of bone mineralization. Predicted to be located in apical plasma membrane and brush border membrane. Is expressed in several structures, including alimentary system; liver; male reproductive gland or organ; spleen; and yolk sac. Used to study basal ganglia calcification. Human ortholog(s) of this gene implicated in basal ganglia calcification. Orthologous to human SLC20A2 (solute carrier family 20 member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in heart adult (RPKM 44.7), cerebellum adult (RPKM 21.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A2; 8 11.42 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (22966771..23059632)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (22476700..22569616)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Astrocytes modulate brain phosphate homeostasis via polarized distribution of phosphate uptake transporter PiT2 and exporter XPR1.
Title: Astrocytes modulate brain phosphate homeostasis via polarized distribution of phosphate uptake transporter PiT2 and exporter XPR1.
Slc20a1/Pit1 and Slc20a2/Pit2 are essential for normal skeletal myofiber function and survival.
Title: Slc20a1/Pit1 and Slc20a2/Pit2 are essential for normal skeletal myofiber function and survival.
Slc20a2, Encoding the Phosphate Transporter PiT2, Is an Important Genetic Determinant of Bone Quality and Strength.
Title: Slc20a2, Encoding the Phosphate Transporter PiT2, Is an Important Genetic Determinant of Bone Quality and Strength.
Loss of Slc20a2 expression is associated with Retarded Growth and brain calcification.
Title: Mice Knocked Out for the Primary Brain Calcification-Associated Gene Slc20a2 Show Unimpaired Prenatal Survival but Retarded Growth and Nodules in the Brain that Grow and Calcify Over Time.
Thus, PiT-2 in vascular smooth muscle cells protects against phosphate-induced vascular calcification.
Title: PiT-2, a type III sodium-dependent phosphate transporter, protects against vascular calcification in mice with chronic kidney disease fed a high-phosphate diet.
PiT2 is necessary for phosphate-dependent secretion of Fgf23, independently from possible endocrine regulatory loops.
Title: Phosphate-dependent FGF23 secretion is modulated by PiT2/Slc20a2.
The increase uptake of pentavalent arsenic in diabetic mouse tissues may be associated with increased PIT1 and/or PIT2 expression.
Title: Increased PIT1 and PIT2 Expression in Streptozotocin (STZ)-induced Diabetic Mice Contributes to Uptake of iAs(V).
Slc20a2 was expressed in tissues that producing or regulating CSF, including choroid plexus, ependyma and arteriolar smooth muscle cells. Haploinsufficient Slc20a2 +/- mice developed age-dependent basal ganglia calcification in glymphatic pathway-associated arterioles. Slc20a2 loss dysregulated phosphate homeostasis and enhanced susceptibility of arteriolar smooth muscle cells to high PO4-induced calcification.
Title: SLC20A2 Deficiency in Mice Leads to Elevated Phosphate Levels in Cerbrospinal Fluid and Glymphatic Pathway-Associated Arteriolar Calcification, and Recapitulates Human Idiopathic Basal Ganglia Calcification.
These results suggest that PiT-2 is involved in normal bone development and growth and plays roles in cortical and trabecular bone metabolism feasibly by regulating local phosphate transport and mineralization processes in the bone.
Title: Loss of PiT-2 results in abnormal bone development and decreased bone mineral density and length in mice.
Slc20a2 is critical for maintaining a physiologic inorganic phosphate level in cerebrospinal fluid
Title: Slc20a2 is critical for maintaining a physiologic inorganic phosphate level in cerebrospinal fluid.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc20a2 (e-PCR), detects polymorphism
- UniSTS:528186

Slc20a2 (e-PCR), detects polymorphism
- UniSTS:258474

Slc20a2 (e-PCR), detects polymorphism
- UniSTS:547019

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phosphate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:phosphate symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables sodium:phosphate symporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables sodium:phosphate symporter activity	ISO Inferred from Sequence Orthology more info
enables virus receptor activity	IEA Inferred from Electronic Annotation more info
enables virus receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in phosphate ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphate ion transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in symbiont entry into host cell	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sodium-dependent phosphate transporter 2

Names: phosphate transporter 2; type III sodium-dependent phosphate transporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001424901.1 → NP_001411830.1 sodium-dependent phosphate transporter 2

Status: VALIDATED

Source sequence(s)

AC140326, AC153017

UniProtKB/Swiss-Prot

E9QLQ8, Q3TBZ8, Q80UP8, Q9ES96
NM_001424902.1 → NP_001411831.1 sodium-dependent phosphate transporter 2

Status: VALIDATED

Source sequence(s)

AC140326, AC153017

UniProtKB/Swiss-Prot

E9QLQ8, Q3TBZ8, Q80UP8, Q9ES96
NM_001424903.1 → NP_001411832.1 sodium-dependent phosphate transporter 2

Status: VALIDATED

Source sequence(s)

AC140326, AC153017

UniProtKB/Swiss-Prot

E9QLQ8, Q3TBZ8, Q80UP8, Q9ES96
NM_011394.4 → NP_035524.2 sodium-dependent phosphate transporter 2

See identical proteins and their annotated locations for NP_035524.2

Status: VALIDATED

Source sequence(s)

AC140326, AC153017

Consensus CDS

CCDS22178.1

UniProtKB/Swiss-Prot

E9QLQ8, Q3TBZ8, Q80UP8, Q9ES96

Related

ENSMUSP00000065935.8, ENSMUST00000067786.9

Conserved Domains (1) summary

pfam01384
Location:465 → 638

PHO4; Phosphate transporter family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

22966771..23059632

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030243367.2 → XP_030099227.1 sodium-dependent phosphate transporter 2 isoform X2

Conserved Domains (1) summary

pfam01384
Location:288 → 461

PHO4; Phosphate transporter family