Rapgef2 Rap guanine nucleotide exchange factor (GEF) 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rapgef2provided by MGI
Official Full Name: Rap guanine nucleotide exchange factor (GEF) 2provided by MGI
Primary source: MGI:MGI:2659071
See related: Ensembl:ENSMUSG00000062232 AllianceGenome:MGI:2659071
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pdzgef1; nRapGEP; CNRasGEF; RA-GEF-1; mKIAA0313; 5830453M24Rik
Summary: Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including cAMP-mediated signaling; cellular response to cAMP; and nervous system development. Is active in postsynapse. Is expressed in embryo; olfactory epithelium; yolk sac endoderm; and yolk sac mesenchyme. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 7. Orthologous to human RAPGEF2 (Rap guanine nucleotide exchange factor 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in frontal lobe adult (RPKM 10.4), cortex adult (RPKM 8.4) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 E3; 3 34.91 cM

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (78969818..79194681, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (79062511..79286545, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The guanine nucleotide exchange factor RapGEF2 is required for ERK-dependent immediate-early gene (Egr1) activation during fear memory formation.
Title: The guanine nucleotide exchange factor RapGEF2 is required for ERK-dependent immediate-early gene (Egr1) activation during fear memory formation.
RAPGEF2 mediates oligomeric Abeta-induced synaptic loss and cognitive dysfunction in the 3xTg-AD mouse model of Alzheimer's disease.
Title: RAPGEF2 mediates oligomeric Aβ-induced synaptic loss and cognitive dysfunction in the 3xTg-AD mouse model of Alzheimer's disease.
Phosphatidic acid-dependent localization and basal de-phosphorylation of RA-GEFs regulate lymphocyte trafficking.
Title: Phosphatidic acid-dependent localization and basal de-phosphorylation of RA-GEFs regulate lymphocyte trafficking.
Phosphatidic acid regulates subcellular distribution of RA-GEFs critical for chemokine-dependent migration.
Title: Phosphatidic acid regulates subcellular distribution of RA-GEFs critical for chemokine-dependent migration.
Rapgef2-conditional knockout (cKO) mice and Rapgef6-KO mice exhibited hyperlocomotion phenotype and working-memory defect, both of which could be recognized as schizophrenia-like behavior.
Title: Comprehensive behavioral analysis of mice deficient in Rapgef2 and Rapgef6, a subfamily of guanine nucleotide exchange factors for Rap small GTPases possessing the Ras/Rap-associating domain.
This study showed here that the guanine nucleotide exchange factor NCS-Rapgef2 is encoded by a neuron-specific transcript from the Rapgef2 gene locus, and functions as an obligate cAMP sensor for dopamine-dependent ERK activation in hippocampus, amygdala, and ventral striatum
Title: NCS-Rapgef2, the Protein Product of the Neuronal Rapgef2 Gene, Is a Specific Activator of D1 Dopamine Receptor-Dependent ERK Phosphorylation in Mouse Brain.
Study show that double knockout of Rapgef6 in Rapgef2-cKO mice (Rapgef2/6-dKO) results in marked enlargement of the ectopic cortical mass. While Rapgef2-cKO affects late-born neurons only, Rapgef2/6-dKO affects both early-born and late-born neurons in the developing brain.
Title: Crucial Role of Rapgef2 and Rapgef6, a Family of Guanine Nucleotide Exchange Factors for Rap1 Small GTPase, in Formation of Apical Surface Adherens Junctions and Neural Progenitor Development in the Mouse Cerebral Cortex.
These results indicate a crucial role of the Rapgef2-Rap1A-ERK-c-jun pathway in regulation of the AJ formation in RGCs.
Title: Rapgef2, a guanine nucleotide exchange factor for Rap1 small GTPases, plays a crucial role in adherence junction (AJ) formation in radial glial cells through ERK-mediated upregulation of the AJ-constituent protein expression.
The essential role of RA-GEF-1 is the proper formation of the cerebral midline commissures.
Title: RA-GEF-1 (Rapgef2) is essential for proper development of the midline commissures.
Rapgef2 deficiency led to embryonic lethality at E11.5 due to severe yolk sac vascular defects.
Title: RapGEF2 is essential for embryonic hematopoiesis but dispensable for adult hematopoiesis.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Rapgef2 (e-PCR), detects polymorphism
- UniSTS:507417

RH125973 (e-PCR)
- UniSTS:162685

RH125415 (e-PCR)
- UniSTS:162237

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables PDZ domain binding	ISS Inferred from Sequence or Structural Similarity more info
enables WW domain binding	ISO Inferred from Sequence Orthology more info
enables WW domain binding	ISS Inferred from Sequence or Structural Similarity more info
enables beta-1 adrenergic receptor binding	ISO Inferred from Sequence Orthology more info
enables beta-1 adrenergic receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables cAMP binding	ISO Inferred from Sequence Orthology more info
enables cAMP binding	ISS Inferred from Sequence or Structural Similarity more info
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables guanyl-nucleotide exchange factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidic acid binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Rap protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in Rap protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brain-derived neurotrophic factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in brain-derived neurotrophic factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in cAMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cAMP	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to cAMP	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cAMP	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to cGMP	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cGMP	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to nerve growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to nerve growth factor stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of endothelial barrier	ISO Inferred from Sequence Orthology more info
involved_in establishment of endothelial barrier	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of endothelial intestinal barrier	ISO Inferred from Sequence Orthology more info
involved_in forebrain neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microvillus assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of melanin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nerve growth factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in nerve growth factor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in neuropeptide signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cAMP-dependent protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cAMP-dependent protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dendritic cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein binding	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of vasculogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell junction assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell junction assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of modification of postsynaptic structure	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of modification of postsynaptic structure	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of modification of postsynaptic structure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic plasticity	ISS Inferred from Sequence or Structural Similarity more info
involved_in ventricular system development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in endocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in endocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in late endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISS Inferred from Sequence or Structural Similarity more info
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in synapse	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: rap guanine nucleotide exchange factor 2

Names: PDZ domain-containing guanine nucleotide exchange factor 1; cyclic nucleotide ras GEF; neural RAP guanine nucleotide exchange protein; ras/Rap1-associating GEF-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001099624.3 → NP_001093094.2 rap guanine nucleotide exchange factor 2 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform 1.

Source sequence(s)

AK147368, BC067056, BP758717

Consensus CDS

CCDS50932.1

UniProtKB/TrEMBL

E9QNQ4, Q6NXI4

Related

ENSMUSP00000113778.2, ENSMUST00000118340.7

Conserved Domains (5) summary

smart00100
Location:134 → 249

cNMP; Cyclic nucleotide-monophosphate binding domain

smart00229
Location:265 → 378

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00155
Location:711 → 936

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

cd00992
Location:382 → 462

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl00155
Location:604 → 688

UBQ; Ubiquitin-like proteins
NM_001310536.2 → NP_001297465.2 rap guanine nucleotide exchange factor 2 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start site compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.

Source sequence(s)

AC124358, AC164560

Consensus CDS

CCDS89637.1

UniProtKB/Swiss-Prot

E9QMD0, Q8CHG7

UniProtKB/TrEMBL

Q6NXI4

Related

ENSMUSP00000114119.2, ENSMUST00000118100.8

Conserved Domains (7) summary

smart00100
Location:136 → 251

cNMP; Cyclic nucleotide-monophosphate binding domain

smart00229
Location:267 → 380

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

PHA03379
Location:1361 → 1482

PHA03379; EBNA-3A; Provisional

cd00155
Location:713 → 938

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

cd00992
Location:384 → 464

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

TIGR02037
Location:404 → 528

degP_htrA_DO; periplasmic serine protease, Do/DeqQ family

cd01785
Location:608 → 690

RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins
NM_001428995.1 → NP_001415924.1 rap guanine nucleotide exchange factor 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC124358, AC157941, AC164560

UniProtKB/TrEMBL

A0A0A6YWG7

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

78969818..79194681 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006502250.5 → XP_006502313.1 rap guanine nucleotide exchange factor 2 isoform X2

UniProtKB/TrEMBL

A0A0A6YWG7

Conserved Domains (8) summary

smart00100
Location:291 → 406

cNMP; Cyclic nucleotide-monophosphate binding domain

smart00229
Location:422 → 535

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

PHA03379
Location:1516 → 1637

PHA03379; EBNA-3A; Provisional

cd00038
Location:37 → 143

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd00155
Location:868 → 1093

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

cd00992
Location:539 → 619

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

TIGR02037
Location:559 → 683

degP_htrA_DO; periplasmic serine protease, Do/DeqQ family

cd01785
Location:763 → 845

RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins
XM_011240277.4 → XP_011238579.1 rap guanine nucleotide exchange factor 2 isoform X3

UniProtKB/TrEMBL

A0A0A6YWG7

Conserved Domains (8) summary

smart00100
Location:297 → 412

cNMP; Cyclic nucleotide-monophosphate binding domain

smart00229
Location:428 → 541

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

PHA03379
Location:1514 → 1635

PHA03379; EBNA-3A; Provisional

cd00038
Location:37 → 143

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd00155
Location:874 → 1078

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

cd00992
Location:545 → 625

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

TIGR02037
Location:565 → 689

degP_htrA_DO; periplasmic serine protease, Do/DeqQ family

cd01785
Location:769 → 851

RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins
XM_011240276.4 → XP_011238578.1 rap guanine nucleotide exchange factor 2 isoform X1

Related

ENSMUSP00000141542.2, ENSMUST00000195708.2

Conserved Domains (8) summary

smart00100
Location:297 → 412

cNMP; Cyclic nucleotide-monophosphate binding domain

smart00229
Location:428 → 541

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

PHA03379
Location:1522 → 1643

PHA03379; EBNA-3A; Provisional

cd00038
Location:37 → 143

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd00155
Location:874 → 1099

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

cd00992
Location:545 → 625

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

TIGR02037
Location:565 → 689

degP_htrA_DO; periplasmic serine protease, Do/DeqQ family

cd01785
Location:769 → 851

RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins
XM_036163389.1 → XP_036019282.1 rap guanine nucleotide exchange factor 2 isoform X5

UniProtKB/TrEMBL

Q6NXI4

Conserved Domains (6) summary

smart00100
Location:175 → 290

cNMP; Cyclic nucleotide-monophosphate binding domain

smart00229
Location:306 → 419

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

PHA03379
Location:1400 → 1521

PHA03379; EBNA-3A; Provisional

cd00155
Location:752 → 977

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

cd00992
Location:423 → 503

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01785
Location:647 → 729

RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins
XM_006502252.5 → XP_006502315.1 rap guanine nucleotide exchange factor 2 isoform X4

UniProtKB/TrEMBL

Q6NXI4

Conserved Domains (7) summary

smart00100
Location:181 → 296

cNMP; Cyclic nucleotide-monophosphate binding domain

smart00229
Location:312 → 425

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

PHA03379
Location:1406 → 1527

PHA03379; EBNA-3A; Provisional

cd00155
Location:758 → 983

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

cd00992
Location:429 → 509

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

TIGR02037
Location:449 → 573

degP_htrA_DO; periplasmic serine protease, Do/DeqQ family

cd01785
Location:653 → 735

RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins
XM_030252869.2 → XP_030108729.1 rap guanine nucleotide exchange factor 2 isoform X6

UniProtKB/TrEMBL

Q6NXI4

Conserved Domains (7) summary

smart00100
Location:117 → 232

cNMP; Cyclic nucleotide-monophosphate binding domain

smart00229
Location:248 → 361

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

PHA03379
Location:1342 → 1463

PHA03379; EBNA-3A; Provisional

cd00155
Location:694 → 919

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

cd00992
Location:365 → 445

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

TIGR02037
Location:385 → 509

degP_htrA_DO; periplasmic serine protease, Do/DeqQ family

cd01785
Location:589 → 671

RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins