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    Ypel5 yippee like 5 [ Mus musculus (house mouse) ]

    Gene ID: 383295, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ypel5provided by MGI
    Official Full Name
    yippee like 5provided by MGI
    Primary source
    MGI:MGI:1916937
    See related
    Ensembl:ENSMUSG00000039770 AllianceGenome:MGI:1916937
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CGI-127; 2310076K21Rik
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in cell population proliferation. Predicted to be located in midbody; mitotic spindle pole; and nucleus. Predicted to be part of ubiquitin ligase complex. Predicted to colocalize with centrosome. Is expressed in brain; intestine; liver; and neural retina. Orthologous to human YPEL5 (yippee like 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 16.8), cerebellum adult (RPKM 15.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ypel5 in Genome Data Viewer
    Location:
    17 E1.3; 17 44.7 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (73143623..73157439)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (72836628..72850444)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene anaplastic lymphoma kinase Neighboring gene STARR-seq mESC enhancer starr_43183 Neighboring gene STARR-seq mESC enhancer starr_43185 Neighboring gene predicted gene, 53975 Neighboring gene STARR-seq mESC enhancer starr_43186 Neighboring gene predicted gene, 53976 Neighboring gene STARR-positive B cell enhancer ABC_E5626 Neighboring gene STARR-seq mESC enhancer starr_43189 Neighboring gene STARR-positive B cell enhancer ABC_E171 Neighboring gene STARR-seq mESC enhancer starr_43192 Neighboring gene STARR-positive B cell enhancer ABC_E4224 Neighboring gene predicted gene, 30256 Neighboring gene predicted gene, 30375

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Association of a Network of Interferon-Stimulated Genes with a Locus Encoding a Negative Regulator of Non-conventional IKK Kinases and IFNB1. Jeidane S, et al. Cell Rep, 2016 Oct 4. PMID 27705791
    2. Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. Hosono K, et al. Gene, 2004 Sep 29. PMID 15556292
    3. YPEL5 protein of the YPEL gene family is involved in the cell cycle progression by interacting with two distinct proteins RanBPM and RanBP10. Hosono K, et al. Genomics, 2010 Aug. PMID 20580816
    4. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ypel5 is a negative regulator of IFNB1 production and innate immune responses that interacts functionally and physically with TBK1/IKBKE kinases
      Title: Association of a Network of Interferon-Stimulated Genes with a Locus Encoding a Negative Regulator of Non-conventional IKK Kinases and IFNB1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in midbody ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitotic spindle pole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein yippee-like 5
    Names
    yippee protein homolog
    NP_001344297.1
    NP_001344298.1
    NP_001344299.1
    NP_001344300.1
    NP_081442.1
    XP_006524601.1
    XP_006524602.1
    XP_030105745.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357368.1 → NP_001344297.1  protein yippee-like 5 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC163036, BQ176693
      Consensus CDS
      CCDS28963.1
      UniProtKB/Swiss-Prot
      P62700, Q543T4
      UniProtKB/TrEMBL
      Q3TDV0, Q3TMG7, Q65Z92
      Related
      ENSMUSP00000156501.2, ENSMUST00000233210.2
      Conserved Domains (1) summary
      cl13152
      Location:15 → 107
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

    2. NM_001357369.1 → NP_001344298.1  protein yippee-like 5 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC163036, BQ176693
      Consensus CDS
      CCDS28963.1
      UniProtKB/Swiss-Prot
      P62700, Q543T4
      UniProtKB/TrEMBL
      Q3TDV0, Q3TMG7, Q65Z92
      Related
      ENSMUSP00000156450.2, ENSMUST00000233886.2
      Conserved Domains (1) summary
      cl13152
      Location:15 → 107
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

    3. NM_001357370.1 → NP_001344299.1  protein yippee-like 5 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC163036, BQ176693
      Consensus CDS
      CCDS28963.1
      UniProtKB/Swiss-Prot
      P62700, Q543T4
      UniProtKB/TrEMBL
      Q3TDV0, Q3TMG7, Q65Z92
      Conserved Domains (1) summary
      cl13152
      Location:15 → 107
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

    4. NM_001357371.1 → NP_001344300.1  protein yippee-like 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC163036, BQ176693
      UniProtKB/TrEMBL
      Q3TDV0, Q3TMG7, Q65Z92
      Conserved Domains (1) summary
      cl13152
      Location:32 → 124
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

    5. NM_027166.6 → NP_081442.1  protein yippee-like 5 isoform 1

      See identical proteins and their annotated locations for NP_081442.1

      Status: VALIDATED

      Source sequence(s)
      AC163036, AK169241, BQ176693, CA556143
      Consensus CDS
      CCDS28963.1
      UniProtKB/Swiss-Prot
      P62700, Q543T4
      UniProtKB/TrEMBL
      Q3TDV0, Q3TMG7, Q65Z92
      Related
      ENSMUSP00000037764.6, ENSMUST00000045174.7
      Conserved Domains (1) summary
      cl13152
      Location:15 → 107
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      73143623..73157439
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524539.3 → XP_006524602.1  protein yippee-like 5 isoform X1

      See identical proteins and their annotated locations for XP_006524602.1

      UniProtKB/TrEMBL
      Q3TDV0, Q3TMG7, Q65Z92
      Conserved Domains (1) summary
      cl13152
      Location:32 → 124
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

    2. XM_030249885.2 → XP_030105745.1  protein yippee-like 5 isoform X1

      UniProtKB/TrEMBL
      Q3TDV0, Q3TMG7, Q65Z92
      Conserved Domains (1) summary
      cl13152
      Location:32 → 124
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

    3. XM_006524538.1 → XP_006524601.1  protein yippee-like 5 isoform X1

      See identical proteins and their annotated locations for XP_006524601.1

      UniProtKB/TrEMBL
      Q3TDV0, Q3TMG7, Q65Z92
      Conserved Domains (1) summary
      cl13152
      Location:32 → 124
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62700.1 GenPept UniProtKB/Swiss-Prot:P62700

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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