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    Ccdc170 coiled-coil domain containing 170 [ Mus musculus (house mouse) ]

    Gene ID: 100504234, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ccdc170provided by MGI
    Official Full Name
    coiled-coil domain containing 170provided by MGI
    Primary source
    MGI:MGI:2685067
    See related
    Ensembl:ENSMUSG00000019767 AllianceGenome:MGI:2685067
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm221
    Summary
    Predicted to enable microtubule binding activity. Predicted to be involved in microtubule cytoskeleton organization. Predicted to be located in cell junction. Predicted to be active in Golgi apparatus. Orthologous to human CCDC170 (coiled-coil domain containing 170). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Ccdc170 in Genome Data Viewer
    Location:
    10 A1; 10 2.06 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (4432312..4514498)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (4482515..4564498)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25630 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:5958087-5958270 Neighboring gene zinc finger and BTB domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E2315 Neighboring gene required for meiotic nuclear division 1 homolog Neighboring gene STARR-seq mESC enhancer starr_25628 Neighboring gene acidic residue methyltransferase 1 Neighboring gene predicted gene, 22739 Neighboring gene STARR-seq mESC enhancer starr_25624 Neighboring gene STARR-seq mESC enhancer starr_25622 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:5733988-5734171 Neighboring gene glutathione S-transferase, pi 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_25621 Neighboring gene STARR-seq mESC enhancer starr_25620 Neighboring gene estrogen receptor 1 (alpha) Neighboring gene STARR-seq mESC enhancer starr_25619 Neighboring gene STARR-seq mESC enhancer starr_25618

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Three functional polymorphisms in CCDC170 were associated with osteoporosis phenotype. Liu X, et al. Biol Open, 2021 Apr 15. PMID 33785515, Free PMC Article
    2. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Three functional polymorphisms in CCDC170 were associated with osteoporosis phenotype.
      Title: Three functional polymorphisms in CCDC170 were associated with osteoporosis phenotype.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    coiled-coil domain-containing protein 170

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195672.2 → NP_001182601.1  coiled-coil domain-containing protein 170 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC156275, AC158617
      Consensus CDS
      CCDS56677.1
      UniProtKB/TrEMBL
      F6ST92
      Related
      ENSMUSP00000019901.6, ENSMUST00000019901.7
      Conserved Domains (1) summary
      COG1196
      Location:28 → 652
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. NM_001370992.1 → NP_001357921.1  coiled-coil domain-containing protein 170 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC156275, AC158617
      Consensus CDS
      CCDS87950.1
      UniProtKB/TrEMBL
      D3YXL0
      Related
      ENSMUSP00000115997.2, ENSMUST00000138112.8
      Conserved Domains (1) summary
      COG1196
      Location:34 → 658
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. NM_001370993.1 → NP_001357922.1  coiled-coil domain-containing protein 170 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC156275, AC158617
      Conserved Domains (2) summary
      COG1196
      Location:123 → 493
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR03346
      Location:434 → 566
      chaperone_ClpB; ATP-dependent chaperone ClpB

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      4432312..4514498
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155445.1 → XP_036011338.1  coiled-coil domain-containing protein 170 isoform X1

      Conserved Domains (2) summary
      COG1196
      Location:60 → 338
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:251 → 563
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. XM_017313751.2 → XP_017169240.1  coiled-coil domain-containing protein 170 isoform X2

      Conserved Domains (1) summary
      COG1196
      Location:38 → 371
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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