ITPRIP inositol 1,4,5-trisphosphate receptor interacting protein [Homo sapiens (human)] - Gene

Summary

Official Symbol: ITPRIPprovided by HGNC
Official Full Name: inositol 1,4,5-trisphosphate receptor interacting proteinprovided by HGNC
Primary source: HGNC:HGNC:29370
See related: Ensembl:ENSG00000148841 MIM:620205; AllianceGenome:HGNC:29370
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: D1A; DANGER; KIAA1754; bA127L20; bA127L20.2
Summary: This gene encodes a membrane-associated protein that binds the inositol 1,4,5-trisphosphate receptor (ITPR). The encoded protein enhances the sensitivity of ITPR to intracellular calcium signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Expression: Broad expression in bone marrow (RPKM 60.0), esophagus (RPKM 14.1) and 17 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q25.1

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (104309700..104338465, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (105197853..105226599, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (106069458..106098223, complement)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ITPRIP promotes glioma progression by linking MYL9 to DAPK1 inhibition.
Title: ITPRIP promotes glioma progression by linking MYL9 to DAPK1 inhibition.
The suggested model of how long noncoding RNAs (lncI) TPRIP-1 orchestrates signal transduction for IFN production illustrates the essential role of lncRNAs in virus elimination.
Title: Long Noncoding RNA ITPRIP-1 Positively Regulates the Innate Immune Response through Promotion of Oligomerization and Activation of MDA5.
High DANGER expression is involved in high glucose-induced radioresistance through inhibiting DAPK-mediated anoikis in non-small cell lung cancer.
Title: DANGER is involved in high glucose-induced radioresistance through inhibiting DAPK-mediated anoikis in non-small cell lung cancer.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Observational study of gene-disease association. (HuGE Navigator)
Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
DANGER appears to allosterically modulate the sensitivity of IP(3) RtoCa(2+) inhibition, which likely alters IP(3)R-mediated Ca(2+) dynamics in cells where DANGER and IP(3)R are co-expressed
Title: DANGER, a novel regulatory protein of inositol 1,4,5-trisphosphate-receptor activity.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp160, precursor	env	HIV-1 gp160 interacts with ITPRIP; predicted interaction to be relevant to viral egress at plasma membrane/extracellular matrix	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH47085 (e-PCR)
- UniSTS:31243

STS-R64153 (e-PCR)
- UniSTS:12088

RH48888 (e-PCR)
- UniSTS:4257

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in extrinsic apoptotic signaling pathway via death domain receptors	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	HDA more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear outer membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: inositol 1,4,5-trisphosphate receptor-interacting protein

Names: DANGER family member 1A; inositol 1,4,5-triphosphate receptor-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001272012.2 → NP_001258941.1 inositol 1,4,5-trisphosphate receptor-interacting protein precursor

See identical proteins and their annotated locations for NP_001258941.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.

Source sequence(s)

AL162742

Consensus CDS

CCDS7557.1

UniProtKB/Swiss-Prot

D3DRA5, Q5JU17, Q8IWB1, Q96MS8, Q9C0A9

Related

ENSP00000350915.2, ENST00000358187.2

Conserved Domains (3) summary

pfam03281
Location:351 → 479

Mab-21; Mab-21 protein

pfam06936
Location:43 → 112

Selenoprotein_S; Selenoprotein S (SelS)

cl11433
Location:12 → 73

DivIC; Septum formation initiator
NM_001272013.2 → NP_001258942.1 inositol 1,4,5-trisphosphate receptor-interacting protein precursor

See identical proteins and their annotated locations for NP_001258942.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.

Source sequence(s)

AL162742

Consensus CDS

CCDS7557.1

UniProtKB/Swiss-Prot

D3DRA5, Q5JU17, Q8IWB1, Q96MS8, Q9C0A9

Related

ENSP00000337178.1, ENST00000337478.3

Conserved Domains (3) summary

pfam03281
Location:351 → 479

Mab-21; Mab-21 protein

pfam06936
Location:43 → 112

Selenoprotein_S; Selenoprotein S (SelS)

cl11433
Location:12 → 73

DivIC; Septum formation initiator
NM_033397.4 → NP_203755.1 inositol 1,4,5-trisphosphate receptor-interacting protein precursor

See identical proteins and their annotated locations for NP_203755.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.

Source sequence(s)

AL162742

Consensus CDS

CCDS7557.1

UniProtKB/Swiss-Prot

D3DRA5, Q5JU17, Q8IWB1, Q96MS8, Q9C0A9

Related

ENSP00000278071.2, ENST00000278071.6

Conserved Domains (3) summary

pfam03281
Location:351 → 479

Mab-21; Mab-21 protein

pfam06936
Location:43 → 112

Selenoprotein_S; Selenoprotein S (SelS)

cl11433
Location:12 → 73

DivIC; Septum formation initiator

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000010.11 Reference GRCh38.p14 Primary Assembly

Range

104309700..104338465 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005270257.3 → XP_005270314.1 inositol 1,4,5-trisphosphate receptor-interacting protein isoform X1

Conserved Domains (3) summary

pfam03281
Location:356 → 484

Mab-21; Mab-21 protein

pfam06936
Location:48 → 117

Selenoprotein_S; Selenoprotein S (SelS)

cl11433
Location:17 → 78

DivIC; Septum formation initiator