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    GAS6-AS1 GAS6 antisense RNA 1 [ Homo sapiens (human) ]

    Gene ID: 650669, updated on 10-Dec-2024

    Summary

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    Official Symbol
    GAS6-AS1provided by HGNC
    Official Full Name
    GAS6 antisense RNA 1provided by HGNC
    Primary source
    HGNC:HGNC:39826
    See related
    AllianceGenome:HGNC:39826
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Ubiquitous expression in lung (RPKM 15.4), endometrium (RPKM 13.5) and 25 other tissues See more
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    Genomic context

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    See GAS6-AS1 in Genome Data Viewer
    Location:
    13q34
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (113815610..113842841)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (113023551..113053129)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (114518583..114545814)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114305936-114306560 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114306561-114307185 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114311832-114312332 Neighboring gene ATPase H+/K+ transporting subunit beta Neighboring gene G protein-coupled receptor kinase 1 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr13:114426222-114426826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114426827-114427432 Neighboring gene basic salivary proline-rich protein 4-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114446225-114446726 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:114456174-114456392 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114461359-114461860 Neighboring gene long intergenic non-protein coding RNA 552 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114462417-114462918 Neighboring gene transmembrane protein 255B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114491163-114491692 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114491693-114492221 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114504133-114505007 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114506713-114507271 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8040 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8041 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8042 Neighboring gene uncharacterized LOC124903220 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114523566-114524115 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114524665-114525213 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8043 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114540573-114541125 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114541680-114542232 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114542404-114542980 Neighboring gene growth arrest specific 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114551447-114552070 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114552071-114552692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114555417-114555918 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114555919-114556418 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114556794-114557508 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114557509-114558222 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114563503-114564094 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5551 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114566463-114567054 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114576933-114577480 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114577481-114578027 Neighboring gene GAS6 divergent transcript Neighboring gene long intergenic non-protein coding RNA 454

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. GAS6-AS1, a long noncoding RNA, functions as a key candidate gene in atrial fibrillation related stroke determined by ceRNA network analysis and WGCNA. Li RB, et al. BMC Med Genomics, 2023 Mar 9. PMID 36894947, Free PMC Article
    2. Low expression of long noncoding RNA GAS6-AS1 predicts a poor prognosis in patients with NSCLC. Han L, et al. Med Oncol, 2013 Dec. PMID 23979857
    3. Long non-coding antisense RNA GAS6-AS1 supports gastric cancer progression via increasing GAS6 expression. Zhang P, et al. Gene, 2019 May 15. PMID 30735718
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GAS6-AS1, a long noncoding RNA, functions as a key candidate gene in atrial fibrillation related stroke determined by ceRNA network analysis and WGCNA.
      Title: GAS6-AS1, a long noncoding RNA, functions as a key candidate gene in atrial fibrillation related stroke determined by ceRNA network analysis and WGCNA.
    2. Study using gastric cancer (GC) tissue samples and mouse xenograft model showed that GAS6-AS1 can control the expression of its cognate sense gene GAS6 at the transcriptional or translational levels by forming a RNA-RNA duplex, significantly driving the aggressive GC phenotype, and consequently inducing an increase of AXL level and promoting AXL signaling pathway activation.
      Title: Long non-coding antisense RNA GAS6-AS1 supports gastric cancer progression via increasing GAS6 expression.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Other Names

    • GAS6 antisense RNA 1 (non-protein coding)

    Clone Names

    • FLJ35543, FLJ41484

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_044995.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AA971263, BC137379, BX385300, DA460725

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      113815610..113842841
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      113023551..113053129
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001039799.1: Suppressed sequence

      Description
      NM_001039799.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.