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    FUT10 fucosyltransferase 10 [ Homo sapiens (human) ]

    Gene ID: 84750, updated on 27-Nov-2024

    Summary

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    Official Symbol
    FUT10provided by HGNC
    Official Full Name
    fucosyltransferase 10provided by HGNC
    Primary source
    HGNC:HGNC:19234
    See related
    Ensembl:ENSG00000172728 MIM:616931; AllianceGenome:HGNC:19234
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FUCTX
    Summary
    Enables fucosyltransferase activity. Involved in N-glycan fucosylation. Located in Golgi apparatus; endoplasmic reticulum; and nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 2.0), placenta (RPKM 1.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FUT10 in Genome Data Viewer
    Location:
    8p12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (33308061..33473146, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (33578178..33744498, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (33228342..33330664, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379362 Neighboring gene MT-ND2 pseudogene 32 Neighboring gene RAN pseudogene 9 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:32986477-32987676 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:33201768-33202321 Neighboring gene NANOG hESC enhancer GRCh37_chr8:33210014-33210633 Neighboring gene RNA, U6 small nuclear 528, pseudogene Neighboring gene RNA binding motif protein 4 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19094 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27218 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19095 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19096 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:33341856-33342492 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:33342520-33342707 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27220 Neighboring gene small nucleolar RNA, C/D box 13 Neighboring gene MAK16 homolog Neighboring gene TELO2 interacting protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Comparison of human and mouse Fuc-TX and Fuc-TXI genes, and expression studies in the mouse. Baboval T, et al. Mamm Genome, 2002 Sep. PMID 12370785
    2. Activity, splice variants, conserved peptide motifs, and phylogeny of two new alpha1,3-fucosyltransferase families (FUT10 and FUT11). Mollicone R, et al. J Biol Chem, 2009 Feb 13. PMID 19088067
    3. Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism. Roos C, et al. J Biol Chem, 2002 Feb 1. PMID 11698403
    4. Spindle Assembly Checkpoint Inhibition Can Resensitize p53-Null Stem Cells to Cancer Chemotherapy. Liu C, et al. Cancer Res, 2019 May 1. PMID 30862715, Free PMC Article
    5. Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers. Ito T, et al. Nat Genet, 2021 Dec. PMID 34857952

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Comparison of human and mouse Fuc-TX and Fuc-TXI genes, and expression studies in the mouse.
      Title: Comparison of human and mouse Fuc-TX and Fuc-TXI genes, and expression studies in the mouse.
    2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    3. Activity, splice variants, conserved peptide motifs, and phylogeny of two new alpha1,3-fucosyltransferase families (FUT10 and FUT11).
      Title: Activity, splice variants, conserved peptide motifs, and phylogeny of two new alpha1,3-fucosyltransferase families (FUT10 and FUT11).
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC11141

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables alpha-(1->3)-fucosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-(1->3)-fucosyltransferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables fucosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-fucose catabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in N-glycan fucosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in N-glycan fucosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cerebral cortex radially oriented cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fertilization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in fucosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hemopoiesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in nervous system development NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in neuroblast migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuronal stem cell division ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neuronal stem cell population maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oligosaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein folding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein glycosylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein targeting NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in wound healing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in Golgi apparatus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    alpha-(1,3)-fucosyltransferase 10
    Names
    alpha (1,3) fucosyltransferase
    alpha 1,3-fucosyl transferase
    fuc-TX
    fucT-X
    fucosyltransferase X
    galactoside 3-L-fucosyltransferase 10
    NP_116053.3
    XP_011542978.1
    XP_011542979.1
    XP_011542981.1
    XP_011542982.1
    XP_011542983.1
    XP_047278281.1
    XP_047278282.1
    XP_054217345.1
    XP_054217346.1
    XP_054217347.1
    XP_054217348.1
    XP_054217349.1
    XP_054217350.1
    XP_054217351.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032664.3 → NP_116053.3  alpha-(1,3)-fucosyltransferase 10

      See identical proteins and their annotated locations for NP_116053.3

      Status: VALIDATED

      Source sequence(s)
      AJ582015, BC063462
      Consensus CDS
      CCDS6088.1
      UniProtKB/Swiss-Prot
      A8KAC8, Q6P4F1, Q70GG3, Q8IVI6, Q8IVI7, Q8IVJ3, Q8TE43, Q9BSR3
      UniProtKB/TrEMBL
      B4DLS4
      Related
      ENSP00000332757.5, ENST00000327671.10
      Conserved Domains (2) summary
      pfam00852
      Location:219 → 354
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:83 → 177
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      33308061..33473146 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011544677.4 → XP_011542979.1  alpha-(1,3)-fucosyltransferase 10 isoform X2

      UniProtKB/TrEMBL
      B4DLS4
      Conserved Domains (2) summary
      pfam00852
      Location:219 → 354
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:83 → 177
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    2. XM_011544676.4 → XP_011542978.1  alpha-(1,3)-fucosyltransferase 10 isoform X1

      UniProtKB/TrEMBL
      B4DLS4
      Conserved Domains (2) summary
      pfam00852
      Location:261 → 396
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:125 → 219
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    3. XM_047422325.1 → XP_047278281.1  alpha-(1,3)-fucosyltransferase 10 isoform X3

    4. XM_011544681.4 → XP_011542983.1  alpha-(1,3)-fucosyltransferase 10 isoform X6

      UniProtKB/TrEMBL
      B4DLS4
      Conserved Domains (2) summary
      pfam00852
      Location:261 → 396
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:125 → 219
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    5. XM_047422326.1 → XP_047278282.1  alpha-(1,3)-fucosyltransferase 10 isoform X7

    6. XM_011544679.4 → XP_011542981.1  alpha-(1,3)-fucosyltransferase 10 isoform X4

      UniProtKB/TrEMBL
      B4DLS4
      Conserved Domains (2) summary
      pfam00852
      Location:261 → 396
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:125 → 219
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    7. XM_011544680.4 → XP_011542982.1  alpha-(1,3)-fucosyltransferase 10 isoform X5

      UniProtKB/TrEMBL
      B4DLS4
      Conserved Domains (2) summary
      pfam00852
      Location:261 → 396
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:125 → 219
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      33578178..33744498 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054361370.1 → XP_054217345.1  alpha-(1,3)-fucosyltransferase 10 isoform X1

    2. XM_054361372.1 → XP_054217347.1  alpha-(1,3)-fucosyltransferase 10 isoform X3

    3. XM_054361371.1 → XP_054217346.1  alpha-(1,3)-fucosyltransferase 10 isoform X2

    4. XM_054361375.1 → XP_054217350.1  alpha-(1,3)-fucosyltransferase 10 isoform X6

    5. XM_054361376.1 → XP_054217351.1  alpha-(1,3)-fucosyltransferase 10 isoform X7

    6. XM_054361373.1 → XP_054217348.1  alpha-(1,3)-fucosyltransferase 10 isoform X4

    7. XM_054361374.1 → XP_054217349.1  alpha-(1,3)-fucosyltransferase 10 isoform X5

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P4F1.2 GenPept UniProtKB/Swiss-Prot:Q6P4F1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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