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    IL4I1 interleukin 4 induced 1 [ Homo sapiens (human) ]

    Gene ID: 259307, updated on 9-Dec-2024

    Summary

    Official Symbol
    IL4I1provided by HGNC
    Official Full Name
    interleukin 4 induced 1provided by HGNC
    Primary source
    HGNC:HGNC:19094
    See related
    Ensembl:ENSG00000104951 MIM:609742; AllianceGenome:HGNC:19094
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LAO; FIG1; LAAO; hIL4I1
    Summary
    This gene encodes a secreted L-amino acid oxidase protein which primarily catabolizes L-phenylalanine and, to a lesser extent, L-arginine. The expression of this gene is induced by the cytokine interleukin 4 in B cells. This gene is also expressed in macrophages and dendritic cells. This protein may play a role immune system escape as it is expressed in tumor-associated macrophages and suppresses T-cell responses. This protein also contains domains thought to be involved in the binding of flavin adenine dinucleotide (FAD) cofactor. Multiple transcript variants encoding different isoforms have been found for this gene. Some transcripts of this gene share a promoter and exons of the 5' UTR with the overlapping NUP62 gene. [provided by RefSeq, Jul 2020]
    Expression
    Broad expression in testis (RPKM 12.4), liver (RPKM 8.9) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See IL4I1 in Genome Data Viewer
    Location:
    19q13.33
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (49889654..49929504, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (52889790..52929639, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (50392911..50432761, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50373269-50373916 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50379233-50380192 Neighboring gene AKT1 substrate 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14965 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:50381153-50382112 Neighboring gene uncharacterized LOC124904743 Neighboring gene TBC1 domain family member 17 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50393336-50394003 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:50394004-50394672 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:50394673-50395339 Neighboring gene microRNA 4750 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14966 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14967 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14968 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:50411173-50411894 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10946 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14969 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:50415677-50416528 Neighboring gene nucleoporin 62 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50424983-50425650 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:50425735-50426488 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10947 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10948 Neighboring gene activating transcription factor 5 Neighboring gene microRNA 4751 Neighboring gene small nucleolar RNA U3 Neighboring gene sialic acid binding Ig like lectin 11

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables L-amino-acid oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables L-amino-acid oxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables L-phenylalaine oxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in immunological synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sperm midpiece IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    L-amino-acid oxidase
    Names
    Fig-1 protein
    IL4-induced protein 1
    interleukin four induced 1
    NP_001244946.1
    NP_001244947.1
    NP_001372568.1
    NP_690863.1
    NP_758962.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021170.1 RefSeqGene

      Range
      37619..44852
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258017.2NP_001244946.1  L-amino-acid oxidase isoform 2 precursor

      See identical proteins and their annotated locations for NP_001244946.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 2. The first two exons of its 5' UTR are shared with an upstream gene. Variants 2, 3 and 4 encode the same protein (isoform 2).
      Source sequence(s)
      AC118342, DQ079589
      Consensus CDS
      CCDS12786.1
      UniProtKB/TrEMBL
      A2RRH1
      Conserved Domains (2) summary
      pfam01593
      Location:91523
      Amino_oxidase; Flavin containing amine oxidoreductase
      pfam13450
      Location:86143
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
    2. NM_001258018.2NP_001244947.1  L-amino-acid oxidase isoform 2 precursor

      See identical proteins and their annotated locations for NP_001244947.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 2. The first two exons of its 5' UTR are shared with an upstream gene. Variants 2, 3 and 4 encode the same protein (isoform 2).
      Source sequence(s)
      AC118342, DQ079588
      Consensus CDS
      CCDS12786.1
      UniProtKB/TrEMBL
      A2RRH1
      Related
      ENSP00000472474.1, ENST00000595948.5
      Conserved Domains (2) summary
      pfam01593
      Location:91523
      Amino_oxidase; Flavin containing amine oxidoreductase
      pfam13450
      Location:86143
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
    3. NM_001385639.1NP_001372568.1  L-amino-acid oxidase isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding region, compared to variant 2, and is expressed from a different promoter. The resulting isoform (3) contains a distinct and shorter N-terminus, as compared to isoform 2.
      Source sequence(s)
      AC118342
      UniProtKB/TrEMBL
      A2RRH1
      Conserved Domains (1) summary
      pfam01593
      Location:46464
      Amino_oxidase; Flavin containing amine oxidoreductase
    4. NM_152899.2NP_690863.1  L-amino-acid oxidase isoform 1 precursor

      See identical proteins and their annotated locations for NP_690863.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and coding region, compared to variant 2, and is expressed from a different promoter. The resulting isoform (1) contains a distinct and shorter N-terminus, as compared to isoform 2.
      Source sequence(s)
      AF293462
      Consensus CDS
      CCDS12787.1
      UniProtKB/Swiss-Prot
      Q1WMJ3, Q4GZN1, Q4GZN2, Q6P2Q3, Q8TEM5, Q96RQ8, Q96RQ9
      UniProtKB/TrEMBL
      A2RRH1
      Related
      ENSP00000375702.1, ENST00000391826.7
      Conserved Domains (1) summary
      pfam01593
      Location:69501
      Amino_oxidase; Flavin containing amine oxidoreductase
    5. NM_172374.3NP_758962.1  L-amino-acid oxidase isoform 2 precursor

      See identical proteins and their annotated locations for NP_758962.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes the longest isoform (2). The first two exons of its 5' UTR are shared with an upstream gene. Variants 2, 3 and 4 encode the same protein (isoform 2).
      Source sequence(s)
      AC118342, DQ079587
      Consensus CDS
      CCDS12786.1
      UniProtKB/TrEMBL
      A2RRH1
      Related
      ENSP00000342557.2, ENST00000341114.7
      Conserved Domains (2) summary
      pfam01593
      Location:91523
      Amino_oxidase; Flavin containing amine oxidoreductase
      pfam13450
      Location:86143
      NAD_binding_8; NAD(P)-binding Rossmann-like domain

    RNA

    1. NR_047577.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains an alternate exon, compared to variant 2. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC011452, AC118342, AJ880389
      Related
      ENST00000601717.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      49889654..49929504 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      52889790..52929639 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)