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    CNRIP1 cannabinoid receptor interacting protein 1 [ Homo sapiens (human) ]

    Gene ID: 25927, updated on 27-Nov-2024

    Summary

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    Official Symbol
    CNRIP1provided by HGNC
    Official Full Name
    cannabinoid receptor interacting protein 1provided by HGNC
    Primary source
    HGNC:HGNC:24546
    See related
    Ensembl:ENSG00000119865 MIM:618538; AllianceGenome:HGNC:24546
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CRIP1; CRIP-1; C2orf32
    Summary
    This gene encodes a protein that interacts with the C-terminal tail of cannabinoid receptor 1. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2013]
    Expression
    Broad expression in brain (RPKM 31.7), ovary (RPKM 14.7) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CNRIP1 in Genome Data Viewer
    Location:
    2p14
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (68284171..68319949, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (68294742..68330519, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (68511303..68547081, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15947 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_59016 Neighboring gene partner of NOB1 homolog Neighboring gene VISTA enhancer hs2040 Neighboring gene protein phosphatase 3 regulatory subunit B, alpha Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:68432700-68433200 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_59162 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_59182 Neighboring gene uncharacterized LOC107985892 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11586 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11587 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11588 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:68480114-68480783 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11589 Neighboring gene Sharpr-MPRA regulatory region 10638 Neighboring gene uncharacterized LOC102724389 Neighboring gene CRISPRi-validated cis-regulatory element chr2.2452 Neighboring gene uncharacterized LOC101927723 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15948 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15949 Neighboring gene pleckstrin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Cannabinoid CB1 receptor-interacting proteins: novel targets for central nervous system drug discovery? Smith TH, et al. Br J Pharmacol, 2010 Jun. PMID 20590557, Free PMC Article
    2. Cannabinoid Receptor Interacting Protein 1a (CRIP1a) in Health and Disease. Oliver EE, et al. Biomolecules, 2020 Nov 27. PMID 33261012, Free PMC Article
    3. Deciphering the Molecular Association of Human CRIP1a with an Agonist-Bound Cannabinoid Receptor 1. Petgrave M, et al. J Chem Inf Model, 2024 Jan 22. PMID 38159053
    4. In silico interaction analysis of cannabinoid receptor interacting protein 1b (CRIP1b) - CB1 cannabinoid receptor. Singh P, et al. J Mol Graph Model, 2017 Oct. PMID 28918320, Free PMC Article
    5. Screening of exon methylation biomarkers for colorectal cancer via LC-MS/MS strategy. Huang Q, et al. J Mass Spectrom, 2017 Dec. PMID 28940471

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deciphering the Molecular Association of Human CRIP1a with an Agonist-Bound Cannabinoid Receptor 1.
      Title: Deciphering the Molecular Association of Human CRIP1a with an Agonist-Bound Cannabinoid Receptor 1.
    2. DNA Methylation of Cannabinoid Receptor Interacting Protein 1 Promotes Pathogenesis of Intrahepatic Cholangiocarcinoma Through Suppressing Parkin-Dependent Pyruvate Kinase M2 Ubiquitination.
      Title: DNA Methylation of Cannabinoid Receptor Interacting Protein 1 Promotes Pathogenesis of Intrahepatic Cholangiocarcinoma Through Suppressing Parkin-Dependent Pyruvate Kinase M2 Ubiquitination.
    3. Cannabinoid Receptor Type 1 Regulates Drug Reward Behavior via Glutamate Decarboxylase 67 Transcription.
      Title: Cannabinoid Receptor Type 1 Regulates Drug Reward Behavior via Glutamate Decarboxylase 67 Transcription.
    4. Cannabinoid Receptor Interacting Protein 1a (CRIP1a) in Health and Disease.
      Title: Cannabinoid Receptor Interacting Protein 1a (CRIP1a) in Health and Disease.
    5. A rare genomic duplication in 2p14 underlies autosomal dominant hearing loss DFNA58.
      Title: A rare genomic duplication in 2p14 underlies autosomal dominant hearing loss DFNA58.
    6. Tat-Cannabinoid Receptor Interacting Protein Reduces Ischemia-Induced Neuronal Damage and Its Possible Relationship with 14-3-3eta.
      Title: Tat-Cannabinoid Receptor Interacting Protein Reduces Ischemia-Induced Neuronal Damage and Its Possible Relationship with 14-3-3η.
    7. Through investigations of the function and structure of CRIP1a, new pharmacotherapies based upon the CRIP-CB1 receptor interaction can be designed to treat diseases such as epilepsy, motor dysfunctions and schizophrenia
      Title: Cannabinoid Receptor Interacting Protein 1a (CRIP1a): Function and Structure.
    8. The Arg82 and Cys126 of CRIP1b are involved in the majority of hydrogen bond interactions with the CB1 receptor and are possible key residues required for interactions between the CB1 receptor and CRIP1b
      Title: In silico interaction analysis of cannabinoid receptor interacting protein 1b (CRIP1b) - CB1 cannabinoid receptor.
    9. CNRIP1 and RUNX3 as potential DNA methylation biomarkers for CRC diagnosis and treatment
      Title: Screening of exon methylation biomarkers for colorectal cancer via LC-MS/MS strategy.
    10. CRIP1a can compete with beta-arrestins for interaction with C-terminal CB1R domains that could affect agonist-driven, beta-arrestin-mediated internalization of the CB1R.
      Title: Cannabinoid Receptor Interacting Protein 1a Competition with β-Arrestin for CB1 Receptor Binding Sites.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    capsid gag The interaction of HIV-1 CA with human cellular cannabinoid receptor interacting protein 1 (CNRIP1) is identified by yeast two-hybrid screen PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp566K1924

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables type 1 cannabinoid receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables type 1 cannabinoid receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CB1 cannabinoid receptor-interacting protein 1
    Names
    cannabinoid receptor CB1-interacting protein 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111101.2 → NP_001104571.1  CB1 cannabinoid receptor-interacting protein 1 isoform CRIP1b

      See identical proteins and their annotated locations for NP_001104571.1

      Status: REVIEWED

      Source sequence(s)
      AC015969
      Consensus CDS
      CCDS46311.1
      UniProtKB/TrEMBL
      B8ZZB8
      Related
      ENSP00000386883.3, ENST00000409559.7
      Conserved Domains (1) summary
      pfam15043
      Location:4 → 110
      CNRIP1; CB1 cannabinoid receptor-interacting protein 1

    2. NM_001371604.1 → NP_001358533.1  CB1 cannabinoid receptor-interacting protein 1 isoform CRIP1a

      Status: REVIEWED

      Source sequence(s)
      AC015969
      Consensus CDS
      CCDS1886.1
      UniProtKB/Swiss-Prot
      B2R4D0, Q49AN4, Q96F85, Q9UFZ0
      Conserved Domains (1) summary
      pfam15043
      Location:4 → 158
      CNRIP1; CB1 cannabinoid receptor-interacting protein 1

    3. NM_001371605.1 → NP_001358534.1  CB1 cannabinoid receptor-interacting protein 1 isoform CRIP1a

      Status: REVIEWED

      Source sequence(s)
      AC015969
      Consensus CDS
      CCDS1886.1
      UniProtKB/Swiss-Prot
      B2R4D0, Q49AN4, Q96F85, Q9UFZ0
      Conserved Domains (1) summary
      pfam15043
      Location:4 → 158
      CNRIP1; CB1 cannabinoid receptor-interacting protein 1

    4. NM_001371606.1 → NP_001358535.1  CB1 cannabinoid receptor-interacting protein 1 isoform CRIP1a

      Status: REVIEWED

      Source sequence(s)
      AC015969
      Consensus CDS
      CCDS1886.1
      UniProtKB/Swiss-Prot
      B2R4D0, Q49AN4, Q96F85, Q9UFZ0
      Conserved Domains (1) summary
      pfam15043
      Location:4 → 158
      CNRIP1; CB1 cannabinoid receptor-interacting protein 1

    5. NM_001371607.1 → NP_001358536.1  CB1 cannabinoid receptor-interacting protein 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC015969
      Conserved Domains (1) summary
      pfam15043
      Location:26 → 129
      CNRIP1; CB1 cannabinoid receptor-interacting protein 1

    6. NM_001371608.1 → NP_001358537.1  CB1 cannabinoid receptor-interacting protein 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC015969
      Conserved Domains (1) summary
      pfam15043
      Location:26 → 129
      CNRIP1; CB1 cannabinoid receptor-interacting protein 1

    7. NM_015463.3 → NP_056278.1  CB1 cannabinoid receptor-interacting protein 1 isoform CRIP1a

      See identical proteins and their annotated locations for NP_056278.1

      Status: REVIEWED

      Source sequence(s)
      AC015969
      Consensus CDS
      CCDS1886.1
      UniProtKB/Swiss-Prot
      B2R4D0, Q49AN4, Q96F85, Q9UFZ0
      Related
      ENSP00000263655.3, ENST00000263655.4
      Conserved Domains (1) summary
      pfam15043
      Location:4 → 158
      CNRIP1; CB1 cannabinoid receptor-interacting protein 1

    RNA

    1. NR_163969.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC015969

    2. NR_163970.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC015969
      Related
      ENST00000481714.1

    3. NR_163971.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC015969

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      68284171..68319949 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      68294742..68330519 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96F85.1 GenPept UniProtKB/Swiss-Prot:Q96F85

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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