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    DLC1 DLC1 Rho GTPase activating protein [ Homo sapiens (human) ]

    Gene ID: 10395, updated on 3-Dec-2024

    Summary

    Official Symbol
    DLC1provided by HGNC
    Official Full Name
    DLC1 Rho GTPase activating proteinprovided by HGNC
    Primary source
    HGNC:HGNC:2897
    See related
    Ensembl:ENSG00000164741 MIM:604258; AllianceGenome:HGNC:2897
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HP; ARHGAP7; STARD12; p122-RhoGAP
    Summary
    This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010]
    Annotation information
    Note: DLC1 (Gene ID: 10395) and DYNLL1 (Gene ID: 8655) share the DLC1 symbol/alias in common. DLC1 is sometimes used as an alternative name for dynein light chain LC8-type 1 (DYNLL1), which can be confused with the official symbol for DLC1 Rho GTPase activating protein (DLC1). [05 Jul 2018]
    Expression
    Broad expression in lung (RPKM 21.4), fat (RPKM 12.0) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See DLC1 in Genome Data Viewer
    Location:
    8p22
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (13083361..13604620, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (13349832..13871204, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (12940870..13462129, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902103 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:12915937-12916437 Neighboring gene RNA, U6 small nuclear 842, pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:12947375-12948574 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:12957644-12958023 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:12962666-12963312 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:12965381-12965880 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:12980176-12980808 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:12980809-12981441 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:12982170-12982670 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:12982671-12983171 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18956 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18957 Neighboring gene uncharacterized LOC101930149 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:13223844-13225043 Neighboring gene MT-ND4 pseudogene 7 Neighboring gene uncharacterized LOC124901890 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_101206 Neighboring gene RNA, 5S ribosomal pseudogene 255 Neighboring gene nuclear transcription factor Y subunit gamma pseudogene Neighboring gene chromosome 8 open reading frame 48 Neighboring gene uncharacterized LOC102725080 Neighboring gene zinc finger protein 654 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Colorectal cancer
    MedGen: C0346629 OMIM: 114500 GeneReviews: Lynch Syndrome
    Compare labs

    EBI GWAS Catalog

    Description
    A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis.
    EBI GWAS Catalog
    Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants.
    EBI GWAS Catalog
    Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ21120

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NOT enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase activator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables GTPase activator activity TAS
    Traceable Author Statement
    more info
     
    enables SH2 domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in focal adhesion assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in forebrain development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in heart morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in hindbrain morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of Rho protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of focal adhesion assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of stress fiber assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neural tube closure ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cysteine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of execution phase of apoptosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    located_in caveola IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cortical actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
     
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    is_active_in membrane raft IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ruffle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    rho GTPase-activating protein 7
    Names
    Rho-GTPase-activating protein 7
    START domain-containing protein 12
    StAR-related lipid transfer (START) domain containing 12
    deleted in liver cancer 1 protein
    epididymis secretory sperm binding protein
    rho-type GTPase-activating protein 7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_015998.2 RefSeqGene

      Range
      94755..526245
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001164271.2NP_001157743.1  rho GTPase-activating protein 7 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains a distinct 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1. Variants 4, 7, 8, and 9 all encode the same isoform (4).
      Source sequence(s)
      AC015641, AF026219, AK289734, AK299049
      Consensus CDS
      CCDS55201.1
      UniProtKB/TrEMBL
      A0AAG2U1V2
      Related
      ENSP00000428028.1, ENST00000520226.5
      Conserved Domains (2) summary
      cd08908
      Location:8041007
      START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
      cd04375
      Location:561779
      RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
    2. NM_001316668.2NP_001303597.1  rho GTPase-activating protein 7 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate exon in place of the first 5 exons compared to variant 1. The resulting isoform (5) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AB051510, AC015641, DA401187
      Consensus CDS
      CCDS83253.1
      UniProtKB/TrEMBL
      A0AAG2U1V2
      Related
      ENSP00000422595.2, ENST00000512044.6
      Conserved Domains (3) summary
      cd08908
      Location:9121115
      START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
      cd09591
      Location:51110
      SAM_DLC1; SAM domain of DLC1 subfamily
      cd04375
      Location:669887
      RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...
    3. NM_001348081.2NP_001335010.1  rho GTPase-activating protein 7 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variant 1, encodes isoform 1.
      Source sequence(s)
      AC015641, AC019270, AC022832, AC022844, AC106845
      Consensus CDS
      CCDS5989.1
      UniProtKB/Swiss-Prot
      B4DR10, B8PTI0, E9PDZ8, E9PF76, E9PGY9, O14868, O43199, Q7Z5R8, Q86UC6, Q96QB1, Q9C0E0, Q9H7A2
      UniProtKB/TrEMBL
      A8K6L7
      Conserved Domains (3) summary
      cd08908
      Location:13151518
      START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
      cd09591
      Location:454513
      SAM_DLC1; SAM domain of DLC1 subfamily
      cd04375
      Location:10721290
      RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
    4. NM_001348082.2NP_001335011.1  rho GTPase-activating protein 7 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variants 4, 8, and 9, encodes isoform 4.
      Source sequence(s)
      AC015641, AC019270, AC022832, AC022844, AC106845
      Consensus CDS
      CCDS55201.1
      UniProtKB/TrEMBL
      A0AAG2U1V2
      Conserved Domains (2) summary
      cd08908
      Location:8041007
      START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
      cd04375
      Location:561779
      RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
    5. NM_001348083.1NP_001335012.1  rho GTPase-activating protein 7 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), as well as variants 4, 7, and 9, encodes isoform 4.
      Source sequence(s)
      AC015641, AC106845
      Consensus CDS
      CCDS55201.1
      UniProtKB/TrEMBL
      A0AAG2U1V2
      Conserved Domains (2) summary
      cd08908
      Location:8041007
      START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
      cd04375
      Location:561779
      RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
    6. NM_001348084.2NP_001335013.1  rho GTPase-activating protein 7 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variants 4, 7, and 8, encodes isoform 4.
      Source sequence(s)
      AC015641
      Consensus CDS
      CCDS55201.1
      UniProtKB/TrEMBL
      A0AAG2U1V2
      Conserved Domains (2) summary
      cd08908
      Location:8041007
      START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
      cd04375
      Location:561779
      RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
    7. NM_001413124.1NP_001400053.1  rho GTPase-activating protein 7 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC015641, AC019270, AC022844, AC106845
      UniProtKB/Swiss-Prot
      B4DR10, B8PTI0, E9PDZ8, E9PF76, E9PGY9, O14868, O43199, Q7Z5R8, Q86UC6, Q96QB1, Q9C0E0, Q9H7A2
      UniProtKB/TrEMBL
      A8K6L7
    8. NM_001413125.1NP_001400054.1  rho GTPase-activating protein 7 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC019270, AC022844, AC106845
    9. NM_001413126.1NP_001400055.1  rho GTPase-activating protein 7 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC015641, AC106845
      UniProtKB/TrEMBL
      A0AAG2U1V2
    10. NM_001413127.1NP_001400056.1  rho GTPase-activating protein 7 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC015641, AC106845
      UniProtKB/TrEMBL
      A0AAG2U1V2
    11. NM_001413128.1NP_001400057.1  rho GTPase-activating protein 7 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC015641, AC106845
      UniProtKB/TrEMBL
      A0AAG2U1V2
    12. NM_001413129.1NP_001400058.1  rho GTPase-activating protein 7 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC015641, AC106845
      UniProtKB/TrEMBL
      A0AAG2U1V2
    13. NM_001413130.1NP_001400059.1  rho GTPase-activating protein 7 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC015641, AC106845
      UniProtKB/TrEMBL
      A0AAG2U1V2
    14. NM_001413131.1NP_001400060.1  rho GTPase-activating protein 7 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC015641, AC106845
      UniProtKB/TrEMBL
      A0AAG2U1V2
    15. NM_001413132.1NP_001400061.1  rho GTPase-activating protein 7 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC015641, AC106845
      UniProtKB/TrEMBL
      A0AAG2U1V2
    16. NM_001413133.1NP_001400062.1  rho GTPase-activating protein 7 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC015641, AC106845
      UniProtKB/TrEMBL
      A0AAG2U1V2
    17. NM_001413134.1NP_001400063.1  rho GTPase-activating protein 7 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC106845
    18. NM_001413135.1NP_001400064.1  rho GTPase-activating protein 7 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC015641
      UniProtKB/TrEMBL
      A0AAG2UXB5, A8K119
    19. NM_001413136.1NP_001400065.1  rho GTPase-activating protein 7 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC015641
      UniProtKB/TrEMBL
      A0AAG2UXB5, A8K119
    20. NM_001413137.1NP_001400066.1  rho GTPase-activating protein 7 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC015641
      UniProtKB/TrEMBL
      A0AAG2U1V2
    21. NM_001413138.1NP_001400067.1  rho GTPase-activating protein 7 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC015641
      UniProtKB/TrEMBL
      A0AAG2U1V2
    22. NM_001413139.1NP_001400068.1  rho GTPase-activating protein 7 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC015641
      UniProtKB/TrEMBL
      A0AAG2UXB5, A8K119
    23. NM_001413140.1NP_001400069.1  rho GTPase-activating protein 7 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC015641
      UniProtKB/TrEMBL
      A0AAG2UXB5, A8K119
    24. NM_006094.5NP_006085.2  rho GTPase-activating protein 7 isoform 2

      See identical proteins and their annotated locations for NP_006085.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains a distinct 5' UTR, lacks a portion of the 5' coding region, and represents use of an alternate promoter, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1. Variant 2 represents the predominant transcript.
      Source sequence(s)
      AC015641, BC095415
      Consensus CDS
      CCDS5990.1
      UniProtKB/TrEMBL
      A0AAG2UXB5, A8K119
      Related
      ENSP00000351797.2, ENST00000358919.6
      Conserved Domains (4) summary
      cd08908
      Location:8781081
      START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
      cd09591
      Location:1776
      SAM_DLC1; SAM domain of DLC1 subfamily
      smart00454
      Location:1776
      SAM; Sterile alpha motif
      cd04375
      Location:635853
      RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
    25. NM_024767.5NP_079043.3  rho GTPase-activating protein 7 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC022844, AC106845, BC049842, DA549448
      Consensus CDS
      CCDS5991.2
      UniProtKB/Swiss-Prot
      Q96QB1
      Related
      ENSP00000425878.1, ENST00000511869.1
    26. NM_182643.3NP_872584.2  rho GTPase-activating protein 7 isoform 1

      See identical proteins and their annotated locations for NP_872584.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variant 1 represents a transcript that is found in low abundance. Variants 1 and 6 both encode the same isoform (1).
      Source sequence(s)
      AB051510, AC015641, AC022844, BC054511, DA549448
      Consensus CDS
      CCDS5989.1
      UniProtKB/Swiss-Prot
      B4DR10, B8PTI0, E9PDZ8, E9PF76, E9PGY9, O14868, O43199, Q7Z5R8, Q86UC6, Q96QB1, Q9C0E0, Q9H7A2
      UniProtKB/TrEMBL
      A8K6L7
      Related
      ENSP00000276297.4, ENST00000276297.9
      Conserved Domains (3) summary
      cd08908
      Location:13151518
      START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
      cd09591
      Location:454513
      SAM_DLC1; SAM domain of DLC1 subfamily
      cd04375
      Location:10721290
      RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      13083361..13604620 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_018654717.1 Reference GRCh38.p14 PATCHES

      Range
      6278952..6332884 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      13349832..13871204 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)