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    GPR31 G protein-coupled receptor 31 [ Homo sapiens (human) ]

    Gene ID: 2853, updated on 9-Dec-2024

    Summary

    Official Symbol
    GPR31provided by HGNC
    Official Full Name
    G protein-coupled receptor 31provided by HGNC
    Primary source
    HGNC:HGNC:4486
    See related
    Ensembl:ENSG00000120436 MIM:602043; AllianceGenome:HGNC:4486
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HETER; HETER1; 12-HETER
    Summary
    Enables G protein-coupled receptor activity and arachidonate binding activity. Involved in G protein-coupled receptor signaling pathway and response to acidic pH. Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Genomic context

    See GPR31 in Genome Data Viewer
    Location:
    6q27
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (167155247..167157980, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (168537922..168540655, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (167568735..167571468, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene C-C motif chemokine receptor 6 Neighboring gene uncharacterized LOC107986672 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25456 Neighboring gene uncharacterized LOC112267970 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:167556216-167557144 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:167557145-167558073 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:167576665-167577653 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:167578457-167579656 Neighboring gene uncharacterized LOC105378123 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:167585168-167585668 Neighboring gene t-complex 10 like 2 (pseudogene) Neighboring gene uncharacterized LOC124901462

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study of autistic-like traits in a general population study of young adults.
    EBI GWAS Catalog

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables arachidonate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables bioactive lipid receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to acidic pH IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to ischemia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to molecule of bacterial origin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor
    Names
    12-(S)-HETE acid receptor
    12-(S)-HETE receptor
    12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (HETE) receptor
    GPR31/12-HETER
    bA517H2.2 (G protein-coupled receptor 31)
    hydroxyeicosatetraenoic (HETE) acid receptor 1
    probable G-protein coupled receptor 31

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005299.3NP_005290.2  12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor

      See identical proteins and their annotated locations for NP_005290.2

      Status: VALIDATED

      Source sequence(s)
      AL121935
      Consensus CDS
      CCDS5299.1
      UniProtKB/Swiss-Prot
      B0M0K2, O00270, Q4VBL3, Q9NQ20
      Related
      ENSP00000355799.2, ENST00000366834.2
      Conserved Domains (1) summary
      pfam00001
      Location:70282
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      167155247..167157980 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      168537922..168540655 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)