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    IFT88 intraflagellar transport 88 [ Homo sapiens (human) ]

    Gene ID: 8100, updated on 27-Nov-2024

    Summary

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    Official Symbol
    IFT88provided by HGNC
    Official Full Name
    intraflagellar transport 88provided by HGNC
    Primary source
    HGNC:HGNC:20606
    See related
    Ensembl:ENSG00000032742 MIM:600595; AllianceGenome:HGNC:20606
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DAF19; TG737; TTC10; hTg737; D13S1056E
    Summary
    This gene encodes a member of the tetratrico peptide repeat (TPR) family. The encoded protein is involved in cilium biogenesis. Mutations of a similar gene in mouse can cause polycystic kidney disease. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2017]
    Expression
    Broad expression in testis (RPKM 23.5), thyroid (RPKM 6.6) and 19 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See IFT88 in Genome Data Viewer
    Location:
    13q12.11
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (20567157..20691444)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (19760320..19884580)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (21141296..21265583)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene crystallin lambda 1 Neighboring gene microRNA 4499 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7422 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7423 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:21067481-21067980 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:21076097-21077093 Neighboring gene Sharpr-MPRA regulatory region 6807 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5153 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7424 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7425 Neighboring gene Sharpr-MPRA regulatory region 3329 Neighboring gene uncharacterized LOC105370103 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5154 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:21141501-21141689 Neighboring gene solute carrier family 35 member E1 pseudogene 1 Neighboring gene RNA, U2 small nuclear 7, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5155 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5156 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5157 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr13:21290864-21291578 Neighboring gene Sharpr-MPRA regulatory region 1468 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:21303728-21304255 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:21304256-21304782 Neighboring gene interleukin 17D Neighboring gene EEF1A lysine methyltransferase 1 Neighboring gene RAN pseudogene 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Characterization of the human homologue of the mouse Tg737 candidate polycystic kidney disease gene. Schrick JJ, et al. Hum Mol Genet, 1995 Apr. PMID 7633404
    2. Loss of heterozygosity of the tumor suppressor gene Tg737 in the side population cells of hepatocellular carcinomas is associated with poor prognosis. Song Z, et al. Mol Biol Rep, 2010 Dec. PMID 20300861
    3. The intraflagellar transport component IFT88/polaris is a centrosomal protein regulating G1-S transition in non-ciliated cells. Robert A, et al. J Cell Sci, 2007 Feb 15. PMID 17264151
    4. Tg737 signaling is required for hypoxia-enhanced invasion and migration of hepatoma cells. You N, et al. J Exp Clin Cancer Res, 2012 Sep 13. PMID 22974282, Free PMC Article
    5. MicroRNA-548a-5p promotes proliferation and inhibits apoptosis in hepatocellular carcinoma cells by targeting Tg737. Zhao G, et al. World J Gastroenterol, 2016 Jun 21. PMID 27340352, Free PMC Article

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Vinblastine Resistance Is Associated with Nephronophthisis 3-Mediated Primary Cilia via Intraflagellar Transport Protein 88 and Apoptosis-Antagonizing Transcription Factor.
      Title: Vinblastine Resistance Is Associated with Nephronophthisis 3-Mediated Primary Cilia via Intraflagellar Transport Protein 88 and Apoptosis-Antagonizing Transcription Factor.
    2. Multifaceted investigation underlies diverse mechanisms contributing to the downregulation of Hedgehog pathway-associated genes INTU and IFT88 in lung adenocarcinoma and uterine corpus endometrial carcinoma.
      Title: Multifaceted investigation underlies diverse mechanisms contributing to the downregulation of Hedgehog pathway-associated genes INTU and IFT88 in lung adenocarcinoma and uterine corpus endometrial carcinoma.
    3. IFT88 controls NuMA enrichment at k-fibers minus-ends to facilitate their re-anchoring into mitotic spindles.
      Title: IFT88 controls NuMA enrichment at k-fibers minus-ends to facilitate their re-anchoring into mitotic spindles.
    4. The Intraflagellar Transport Protein IFT88 Is Disrupted in Cystic Fibrosis.
      Title: Ciliary Localization of the Intraflagellar Transport Protein IFT88 Is Disrupted in Cystic Fibrosis.
    5. Significant association was found between IFT88 rs9509311 and rs2497490 and Nonsyndromic cleft lip with or without cleft palate (NSCLP) in non-Hispanic white families (p = .004 and .005), while nominal associations were found for rs7998361 and rs9509307 (p < .05). Pairwise association analyses also showed nominal associations between NSCLP in both NHW and Hispanic data sets (p < .05).
      Title: Association of IFT88 gene variants with nonsyndromic cleft lip with or without cleft palate.
    6. TCTN2 Depletion-Induced IFT88 Lumen Leakage and Ciliary Weakening
      Title: Super-Resolution Imaging Reveals TCTN2 Depletion-Induced IFT88 Lumen Leakage and Ciliary Weakening.
    7. These observations suggest that the rare and unique combination of IFT88 alleles observed in this study provide insight into the physiological role of IFT88 in humans and the likely mechanism underlying retinal pathology in the pedigree with inherited retinal degeneration
      Title: IFT88 mutations identified in individuals with non-syndromic recessive retinal degeneration result in abnormal ciliogenesis.
    8. IFT88/primary cilia play a role in metabolic reprogramming in thyroid cancer cells.
      Title: Loss-of-function of IFT88 determines metabolic phenotypes in thyroid cancer.
    9. BFGF also upregulated the mRNA and protein expression of IFT88 in primary cultured chondrocytes.
      Title: Basic fibroblast growth factor increases IFT88 expression in chondrocytes.
    10. Data suggest that the function of the fusion transcript crystallin, lambda 1 protein - intraflagellar transport 88 (CRYL1-IFT88) is closed to CRYL1 because it contained most of domain of CRYL1.
      Title: Transcriptome profiling identifies a recurrent CRYL1-IFT88 chimeric transcript in hepatocellular carcinoma.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression.
    EBI GWAS Catalog
    Genetics of coronary artery calcification among African Americans, a meta-analysis.
    EBI GWAS Catalog
    GWAS of dental caries patterns in the permanent dentition.
    EBI GWAS Catalog

    Variation

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    See Variation Viewer (GRCh37.p13)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC26259

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables kinesin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cilium assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in inner ear receptor cell stereocilium organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intraciliary anterograde transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in intraciliary transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in kidney development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in non-motile cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of autophagosome assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to silicon dioxide IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centriole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary basal body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in ciliary base IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary tip TAS
    Traceable Author Statement
    more info
    		  
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cilium NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cilium TAS
    Traceable Author Statement
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of intraciliary transport particle B IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of intraciliary transport particle B ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in manchette ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in motile cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in non-motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm flagellum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in sperm head-tail coupling apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    intraflagellar transport protein 88 homolog
    Names
    TPR repeat protein 10
    intraflagellar transport 88 homolog
    polaris homolog
    probe hTg737 (polycystic kidney disease, autosomal recessive)
    recessive polycystic kidney disease protein Tg737 homolog
    testicular tissue protein Li 93
    tetratricopeptide repeat domain 10
    tetratricopeptide repeat protein 10

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001318491.2 → NP_001305420.1  intraflagellar transport protein 88 homolog isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks multiple alternate exons in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (3) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK300769, AL161772, BC030776, BG182322
      UniProtKB/TrEMBL
      B3KX42
      Conserved Domains (6) summary
      sd00006
      Location:465 → 493
      TPR; TPR repeat [structural motif]
      cd15832
      Location:210 → 241
      SNAP; TPR repeat [structural motif]
      pfam00515
      Location:500 → 524
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:464 → 528
      TPR_11; TPR repeat
      pfam13424
      Location:216 → 285
      TPR_12; Tetratricopeptide repeat
      cl24038
      Location:210 → 311
      SNAP; Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family

    2. NM_001318493.2 → NP_001305422.1  intraflagellar transport protein 88 homolog isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains an additional segment in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1 and 4 encode the same isoform (1).
      Source sequence(s)
      AK126668, AK308281, AL161772, BC059357, BG182322
      Consensus CDS
      CCDS31944.1
      UniProtKB/TrEMBL
      B3KX42
      Conserved Domains (2) summary
      sd00006
      Location:493 → 521
      TPR; TPR repeat [structural motif]
      cl26002
      Location:222 → 730
      TPR_11; TPR repeat

    3. NM_001353565.2 → NP_001340494.1  intraflagellar transport protein 88 homolog isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variants 1, 4, 7, and 8, encodes isoform 1.
      Source sequence(s)
      AL161772, AL590096
      Consensus CDS
      CCDS31944.1
      UniProtKB/TrEMBL
      B3KX42
      Conserved Domains (2) summary
      sd00006
      Location:493 → 521
      TPR; TPR repeat [structural motif]
      cl26002
      Location:222 → 730
      TPR_11; TPR repeat

    4. NM_001353566.2 → NP_001340495.1  intraflagellar transport protein 88 homolog isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variants 1, 4, 6, and 8, encodes isoform 1.
      Source sequence(s)
      AL161772, AL590096
      Consensus CDS
      CCDS31944.1
      UniProtKB/TrEMBL
      B3KX42
      Conserved Domains (2) summary
      sd00006
      Location:493 → 521
      TPR; TPR repeat [structural motif]
      cl26002
      Location:222 → 730
      TPR_11; TPR repeat

    5. NM_001353567.2 → NP_001340496.1  intraflagellar transport protein 88 homolog isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), as well as variants 1, 4, 6, and 7, encodes isoform 1.
      Source sequence(s)
      AL161772, AL590096
      Consensus CDS
      CCDS31944.1
      UniProtKB/TrEMBL
      B3KX42
      Conserved Domains (2) summary
      sd00006
      Location:493 → 521
      TPR; TPR repeat [structural motif]
      cl26002
      Location:222 → 730
      TPR_11; TPR repeat

    6. NM_001353568.2 → NP_001340497.1  intraflagellar transport protein 88 homolog isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variant 2, encodes isoform 2.
      Source sequence(s)
      AL161772, AL590096
      Consensus CDS
      CCDS31945.1
      UniProtKB/Swiss-Prot
      A2A491, B4DUS2, Q13099, Q5SZJ6, Q8N719
      UniProtKB/TrEMBL
      A0A140VJL7, B3KX42
      Conserved Domains (2) summary
      TIGR02917
      Location:213 → 721
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:484 → 512
      TPR; TPR repeat [structural motif]

    7. NM_001353569.2 → NP_001340498.1  intraflagellar transport protein 88 homolog isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variant 11, encodes isoform 5.
      Source sequence(s)
      AL161772, AL590096
      UniProtKB/TrEMBL
      B3KX42
      Conserved Domains (3) summary
      COG0457
      Location:235 → 509
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:459 → 487
      TPR; TPR repeat [structural motif]
      cl26002
      Location:397 → 666
      TPR_11; TPR repeat

    8. NM_001353570.2 → NP_001340499.1  intraflagellar transport protein 88 homolog isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variant 10, encodes isoform 5.
      Source sequence(s)
      AL161772, AL590096
      UniProtKB/TrEMBL
      B3KX42
      Conserved Domains (3) summary
      COG0457
      Location:235 → 509
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:459 → 487
      TPR; TPR repeat [structural motif]
      cl26002
      Location:397 → 666
      TPR_11; TPR repeat

    9. NM_001353571.2 → NP_001340500.1  intraflagellar transport protein 88 homolog isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL161772, AL590096
      UniProtKB/TrEMBL
      B3KX42
      Conserved Domains (3) summary
      smart00028
      Location:238 → 265
      TPR; Tetratricopeptide repeats
      sd00006
      Location:450 → 478
      TPR; TPR repeat [structural motif]
      cl26002
      Location:388 → 657
      TPR_11; TPR repeat

    10. NM_001353572.2 → NP_001340501.1  intraflagellar transport protein 88 homolog isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL161772, AL590096
      UniProtKB/TrEMBL
      B3KX42
      Conserved Domains (2) summary
      sd00006
      Location:484 → 512
      TPR; TPR repeat [structural motif]
      cl26002
      Location:213 → 721
      TPR_11; TPR repeat

    11. NM_001353573.2 → NP_001340502.1  intraflagellar transport protein 88 homolog isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL161772, AL590096
      UniProtKB/TrEMBL
      B3KX42
      Conserved Domains (2) summary
      sd00006
      Location:436 → 464
      TPR; TPR repeat [structural motif]
      cl26002
      Location:184 → 664
      TPR_11; TPR repeat

    12. NM_001353574.2 → NP_001340503.1  intraflagellar transport protein 88 homolog isoform 9

      Status: REVIEWED

      Source sequence(s)
      AL161772, AL590096
      UniProtKB/TrEMBL
      B3KX42
      Conserved Domains (3) summary
      smart00028
      Location:219 → 246
      TPR; Tetratricopeptide repeats
      sd00006
      Location:431 → 459
      TPR; TPR repeat [structural motif]
      cl26002
      Location:369 → 638
      TPR_11; TPR repeat

    13. NM_001353575.2 → NP_001340504.1  intraflagellar transport protein 88 homolog isoform 10

      Status: REVIEWED

      Source sequence(s)
      AL161772, AL590096
      UniProtKB/TrEMBL
      B3KX42
      Conserved Domains (2) summary
      sd00006
      Location:465 → 493
      TPR; TPR repeat [structural motif]
      cl26002
      Location:194 → 674
      TPR_11; TPR repeat

    14. NM_001353576.2 → NP_001340505.1  intraflagellar transport protein 88 homolog isoform 11

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17), as well as variantm18, encodes isoform 11.
      Source sequence(s)
      AL161772, AL590096
      UniProtKB/TrEMBL
      B3KX42
      Conserved Domains (3) summary
      COG0457
      Location:235 → 509
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:459 → 487
      TPR; TPR repeat [structural motif]
      cl26002
      Location:397 → 666
      TPR_11; TPR repeat

    15. NM_001353577.2 → NP_001340506.1  intraflagellar transport protein 88 homolog isoform 11

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18), as well as variant 17, encodes isoform 11.
      Source sequence(s)
      AL161772, AL590096
      UniProtKB/TrEMBL
      B3KX42
      Conserved Domains (3) summary
      COG0457
      Location:235 → 509
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:459 → 487
      TPR; TPR repeat [structural motif]
      cl26002
      Location:397 → 666
      TPR_11; TPR repeat

    16. NM_001353578.2 → NP_001340507.1  intraflagellar transport protein 88 homolog isoform 12

      Status: REVIEWED

      Source sequence(s)
      AL161772, AL590096
      UniProtKB/TrEMBL
      B3KX42
      Conserved Domains (3) summary
      smart00028
      Location:238 → 265
      TPR; Tetratricopeptide repeats
      sd00006
      Location:450 → 478
      TPR; TPR repeat [structural motif]
      cl26002
      Location:388 → 657
      TPR_11; TPR repeat

    17. NM_001353579.2 → NP_001340508.1  intraflagellar transport protein 88 homolog isoform 13

      Status: REVIEWED

      Source sequence(s)
      AL161772, AL590096
      Conserved Domains (2) summary
      sd00006
      Location:273 → 301
      TPR; TPR repeat [structural motif]
      cl26002
      Location:2 → 510
      TPR_11; TPR repeat

    18. NM_006531.5 → NP_006522.2  intraflagellar transport protein 88 homolog isoform 2

      See identical proteins and their annotated locations for NP_006522.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks multiple alternate exons in the 5' UTR and lacks a portion of the 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1. Variants 2 and 9 both encode the same isoform (2).
      Source sequence(s)
      AK126668, AK308281, AK310223, AL161772, BC059357, BG182322
      Consensus CDS
      CCDS31945.1
      UniProtKB/Swiss-Prot
      A2A491, B4DUS2, Q13099, Q5SZJ6, Q8N719
      UniProtKB/TrEMBL
      A0A140VJL7, B3KX42
      Related
      ENSP00000261632.5, ENST00000351808.10
      Conserved Domains (2) summary
      TIGR02917
      Location:213 → 721
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:484 → 512
      TPR; TPR repeat [structural motif]

    19. NM_175605.5 → NP_783195.2  intraflagellar transport protein 88 homolog isoform 1

      See identical proteins and their annotated locations for NP_783195.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1, 4, 6, 7, and 8 all encode the same isoform (1).
      Source sequence(s)
      AK126668, AL161772, BC030776, BG182322
      Consensus CDS
      CCDS31944.1
      UniProtKB/TrEMBL
      B3KX42
      Related
      ENSP00000323580.6, ENST00000319980.10
      Conserved Domains (2) summary
      sd00006
      Location:493 → 521
      TPR; TPR repeat [structural motif]
      cl26002
      Location:222 → 730
      TPR_11; TPR repeat

    RNA

    1. NR_134653.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs at both the 5' and 3' ends, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK126668, AK310223, AL161772, BC059357, BG182322

    2. NR_148462.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL161772, AL590096

    3. NR_148463.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL161772, AL590096

    4. NR_148464.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL161772, AL590096

    5. NR_148465.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL161772, AL590096

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      20567157..20691444
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047430655.1 → XP_047286611.1  intraflagellar transport protein 88 homolog isoform X1

      UniProtKB/Swiss-Prot
      A2A491, B4DUS2, Q13099, Q5SZJ6, Q8N719
      UniProtKB/TrEMBL
      A0A140VJL7

    2. XM_017020757.2 → XP_016876246.1  intraflagellar transport protein 88 homolog isoform X1

      UniProtKB/Swiss-Prot
      A2A491, B4DUS2, Q13099, Q5SZJ6, Q8N719
      UniProtKB/TrEMBL
      A0A140VJL7, B3KX42
      Conserved Domains (2) summary
      TIGR02917
      Location:213 → 721
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:484 → 512
      TPR; TPR repeat [structural motif]

    3. XM_017020763.2 → XP_016876252.1  intraflagellar transport protein 88 homolog isoform X8

      UniProtKB/TrEMBL
      B3KX42

    4. XM_017020762.2 → XP_016876251.1  intraflagellar transport protein 88 homolog isoform X6

      UniProtKB/TrEMBL
      B3KX42

    5. XM_024449413.2 → XP_024305181.1  intraflagellar transport protein 88 homolog isoform X12

      UniProtKB/TrEMBL
      B3KX42
      Conserved Domains (3) summary
      smart00028
      Location:228 → 255
      TPR; Tetratricopeptide repeats
      sd00006
      Location:440 → 468
      TPR; TPR repeat [structural motif]
      cl26002
      Location:378 → 647
      TPR_11; TPR repeat

    6. XM_047430660.1 → XP_047286616.1  intraflagellar transport protein 88 homolog isoform X4

    7. XM_047430670.1 → XP_047286626.1  intraflagellar transport protein 88 homolog isoform X14

    8. XM_047430656.1 → XP_047286612.1  intraflagellar transport protein 88 homolog isoform X2

    9. XM_047430661.1 → XP_047286617.1  intraflagellar transport protein 88 homolog isoform X5

    10. XM_047430671.1 → XP_047286627.1  intraflagellar transport protein 88 homolog isoform X14

    11. XM_047430667.1 → XP_047286623.1  intraflagellar transport protein 88 homolog isoform X11

    12. XM_047430662.1 → XP_047286618.1  intraflagellar transport protein 88 homolog isoform X6

    13. XM_047430659.1 → XP_047286615.1  intraflagellar transport protein 88 homolog isoform X4

    14. XM_047430657.1 → XP_047286613.1  intraflagellar transport protein 88 homolog isoform X2

    15. XM_047430668.1 → XP_047286624.1  intraflagellar transport protein 88 homolog isoform X12

    16. XM_006719870.4 → XP_006719933.1  intraflagellar transport protein 88 homolog isoform X1

      See identical proteins and their annotated locations for XP_006719933.1

      UniProtKB/Swiss-Prot
      A2A491, B4DUS2, Q13099, Q5SZJ6, Q8N719
      UniProtKB/TrEMBL
      A0A140VJL7, B3KX42
      Conserved Domains (2) summary
      TIGR02917
      Location:213 → 721
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:484 → 512
      TPR; TPR repeat [structural motif]

    17. XM_047430666.1 → XP_047286622.1  intraflagellar transport protein 88 homolog isoform X10

    18. XM_047430665.1 → XP_047286621.1  intraflagellar transport protein 88 homolog isoform X9

    19. XM_047430658.1 → XP_047286614.1  intraflagellar transport protein 88 homolog isoform X3

    20. XM_047430663.1 → XP_047286619.1  intraflagellar transport protein 88 homolog isoform X7

    21. XM_047430674.1 → XP_047286630.1  intraflagellar transport protein 88 homolog isoform X17

    22. XM_047430673.1 → XP_047286629.1  intraflagellar transport protein 88 homolog isoform X16

    23. XM_047430672.1 → XP_047286628.1  intraflagellar transport protein 88 homolog isoform X15

    24. XM_047430675.1 → XP_047286631.1  intraflagellar transport protein 88 homolog isoform X18

    25. XM_047430669.1 → XP_047286625.1  intraflagellar transport protein 88 homolog isoform X13

    26. XM_047430664.1 → XP_047286620.1  intraflagellar transport protein 88 homolog isoform X8

    27. XM_047430676.1 → XP_047286632.1  intraflagellar transport protein 88 homolog isoform X19

    28. XM_017020775.2 → XP_016876264.1  intraflagellar transport protein 88 homolog isoform X20

    29. XM_017020776.2 → XP_016876265.1  intraflagellar transport protein 88 homolog isoform X23

    30. XM_047430679.1 → XP_047286635.1  intraflagellar transport protein 88 homolog isoform X25

    31. XM_047430678.1 → XP_047286634.1  intraflagellar transport protein 88 homolog isoform X24

    32. XM_024449415.2 → XP_024305183.1  intraflagellar transport protein 88 homolog isoform X21

      Conserved Domains (2) summary
      COG0457
      Location:199 → 352
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:247 → 270
      TPR; TPR repeat [structural motif]

    33. XM_047430677.1 → XP_047286633.1  intraflagellar transport protein 88 homolog isoform X22

    RNA

    1. XR_007063700.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      19760320..19884580
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054375008.1 → XP_054230983.1  intraflagellar transport protein 88 homolog isoform X1

    2. XM_054375009.1 → XP_054230984.1  intraflagellar transport protein 88 homolog isoform X1

    3. XM_054375020.1 → XP_054230995.1  intraflagellar transport protein 88 homolog isoform X8

    4. XM_054375016.1 → XP_054230991.1  intraflagellar transport protein 88 homolog isoform X6

    5. XM_054375024.1 → XP_054230999.1  intraflagellar transport protein 88 homolog isoform X12

    6. XM_054375014.1 → XP_054230989.1  intraflagellar transport protein 88 homolog isoform X4

    7. XM_054375027.1 → XP_054231002.1  intraflagellar transport protein 88 homolog isoform X14

    8. XM_054375010.1 → XP_054230985.1  intraflagellar transport protein 88 homolog isoform X2

    9. XM_054375015.1 → XP_054230990.1  intraflagellar transport protein 88 homolog isoform X5

    10. XM_054375028.1 → XP_054231003.1  intraflagellar transport protein 88 homolog isoform X14

    11. XM_054375023.1 → XP_054230998.1  intraflagellar transport protein 88 homolog isoform X11

    12. XM_054375017.1 → XP_054230992.1  intraflagellar transport protein 88 homolog isoform X6

    13. XM_054375013.1 → XP_054230988.1  intraflagellar transport protein 88 homolog isoform X4

    14. XM_054375011.1 → XP_054230986.1  intraflagellar transport protein 88 homolog isoform X2

    15. XM_054375025.1 → XP_054231000.1  intraflagellar transport protein 88 homolog isoform X12

    16. XM_054375007.1 → XP_054230982.1  intraflagellar transport protein 88 homolog isoform X1

    17. XM_054375022.1 → XP_054230997.1  intraflagellar transport protein 88 homolog isoform X10

    18. XM_054375021.1 → XP_054230996.1  intraflagellar transport protein 88 homolog isoform X9

    19. XM_054375012.1 → XP_054230987.1  intraflagellar transport protein 88 homolog isoform X3

    20. XM_054375018.1 → XP_054230993.1  intraflagellar transport protein 88 homolog isoform X7

    21. XM_054375031.1 → XP_054231006.1  intraflagellar transport protein 88 homolog isoform X17

    22. XM_054375030.1 → XP_054231005.1  intraflagellar transport protein 88 homolog isoform X16

    23. XM_054375029.1 → XP_054231004.1  intraflagellar transport protein 88 homolog isoform X15

    24. XM_054375032.1 → XP_054231007.1  intraflagellar transport protein 88 homolog isoform X18

    25. XM_054375026.1 → XP_054231001.1  intraflagellar transport protein 88 homolog isoform X13

    26. XM_054375019.1 → XP_054230994.1  intraflagellar transport protein 88 homolog isoform X8

    27. XM_054375033.1 → XP_054231008.1  intraflagellar transport protein 88 homolog isoform X19

    28. XM_054375035.1 → XP_054231010.1  intraflagellar transport protein 88 homolog isoform X26

    29. XM_054375034.1 → XP_054231009.1  intraflagellar transport protein 88 homolog isoform X20

    30. XM_054375038.1 → XP_054231013.1  intraflagellar transport protein 88 homolog isoform X23

    31. XM_054375040.1 → XP_054231015.1  intraflagellar transport protein 88 homolog isoform X25

    32. XM_054375039.1 → XP_054231014.1  intraflagellar transport protein 88 homolog isoform X24

    33. XM_054375037.1 → XP_054231012.1  intraflagellar transport protein 88 homolog isoform X22

    34. XM_054375036.1 → XP_054231011.1  intraflagellar transport protein 88 homolog isoform X21

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13099.3 GenPept UniProtKB/Swiss-Prot:Q13099

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