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    ICMT isoprenylcysteine carboxyl methyltransferase [ Homo sapiens (human) ]

    Gene ID: 23463, updated on 27-Nov-2024

    Summary

    Official Symbol
    ICMTprovided by HGNC
    Official Full Name
    isoprenylcysteine carboxyl methyltransferaseprovided by HGNC
    Primary source
    HGNC:HGNC:5350
    See related
    Ensembl:ENSG00000116237 MIM:605851; AllianceGenome:HGNC:5350
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PCMT; PPMT; PCCMT; HSTE14; MST098; MSTP098
    Summary
    This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in kidney (RPKM 21.7), placenta (RPKM 18.3) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ICMT in Genome Data Viewer
    Location:
    1p36.31
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (6221193..6235964, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (5746837..5761608, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (6281253..6296024, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L22 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 138 Neighboring gene Sharpr-MPRA regulatory region 5942 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6265555-6266374 Neighboring gene RNF207 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 139 Neighboring gene Sharpr-MPRA regulatory region 13921 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 140 Neighboring gene ring finger protein 207 Neighboring gene MPRA-validated peak28 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr1:6279526-6279711 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 141 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 142 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6296257-6297229 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6299873-6300619 Neighboring gene ICMT divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6304377-6304934 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:6305171-6305522 Neighboring gene hes family bHLH transcription factor 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC39955

    General protein information

    Preferred Names
    protein-S-isoprenylcysteine O-methyltransferase
    Names
    prenylated protein carboxyl methyltransferase
    prenylcysteine carboxyl methyltransferase
    NP_036537.1
    XP_011539442.1
    XP_047272548.1
    XP_054191679.1
    XP_054191680.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012405.4NP_036537.1  protein-S-isoprenylcysteine O-methyltransferase

      See identical proteins and their annotated locations for NP_036537.1

      Status: REVIEWED

      Source sequence(s)
      AL031847, BC028168, CN343480
      Consensus CDS
      CCDS61.1
      UniProtKB/Swiss-Prot
      O60725, Q6FHT0
      Related
      ENSP00000343552.5, ENST00000343813.10
      Conserved Domains (1) summary
      pfam04140
      Location:164257
      ICMT; Isoprenylcysteine carboxyl methyltransferase (ICMT) family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      6221193..6235964 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011541140.3XP_011539442.1  protein-S-isoprenylcysteine O-methyltransferase isoform X1

      See identical proteins and their annotated locations for XP_011539442.1

      UniProtKB/TrEMBL
      B3KS61
      Conserved Domains (1) summary
      pfam04140
      Location:68161
      ICMT; Isoprenylcysteine carboxyl methyltransferase (ICMT) family
    2. XM_047416592.1XP_047272548.1  protein-S-isoprenylcysteine O-methyltransferase isoform X2

      UniProtKB/TrEMBL
      A6NKX2, Q7Z750
      Related
      ENSP00000466222.1, ENST00000489498.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      5746837..5761608 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054335704.1XP_054191679.1  protein-S-isoprenylcysteine O-methyltransferase isoform X1

      UniProtKB/TrEMBL
      B3KS61
    2. XM_054335705.1XP_054191680.1  protein-S-isoprenylcysteine O-methyltransferase isoform X2

      UniProtKB/TrEMBL
      A6NKX2, Q7Z750

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_170705.1: Suppressed sequence

      Description
      NM_170705.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.